The T309G MDM2 gene polymorphism is a novel risk factor for proliferative vitreoretinopathy

scientific article

The T309G MDM2 gene polymorphism is a novel risk factor for proliferative vitreoretinopathy is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...882283P
P356DOI10.1371/JOURNAL.PONE.0082283
P932PMC publication ID3857251
P698PubMed publication ID24349246
P5875ResearchGate publication ID262045815

P50authorRobert MacLarenQ27537201
Irene Rodríguez-HernándezQ87342354
José-Carlos PastorQ87896715
Rogelio Gonzalez-SarmientoQ89728620
Amândio A Rocha-SousaQ55168467
Itziar FernándezQ56440402
P2093author name stringSalvador Pastor-Idoate
Jimena Rojas
José M Ruiz-Moreno
Steven Harsum
David Charteris
Genetics on PVR Study Group
Jan C VanMeurs
María T García-Gutiérrez
Yashin Ramkissoon
P2860cites workA new look at the statistical model identificationQ26778401
Causes of failure after initial vitreoretinal surgery for severe proliferative vitreoretinopathyQ68178279
Retinal wound healing. Cellular activity at the vitreoretinal interfaceQ70011862
The classification of retinal detachment with proliferative vitreoretinopathyQ71748348
Apoptotic photoreceptor degeneration in experimental retinal detachmentQ72190360
Proliferative vitreoretinopathy: an overviewQ77144020
The insulin-like growth factor system modulates retinal pigment epithelial cell tractional force generationQ80050309
Intraretinal immunohistochemistry findings in proliferative vitreoretinopathy with retinal shorteningQ83298628
Cytokine gene polymorphisms in retinal detachment patients with and without proliferative vitreoretinopathy: a preliminary studyQ83355824
Single-nucleotide polymorphisms p53 G72C and Mdm2 T309G in patients with psoriasis, psoriatic arthritis, and SAPHO syndromeQ84586158
The p53 codon 72 polymorphism (rs1042522) is associated with proliferative vitreoretinopathy: the Retina 4 ProjectQ85599752
A genetic case-control study confirms the implication of SMAD7 and TNF locus in the development of proliferative vitreoretinopathy.Q49030836
Activation of signaling pathways and stress-response genes in an experimental model of retinal detachment.Q54611978
Multiplex Bead Analysis of Vitreous Humor of Patients with Vitreoretinal DisordersQ60207394
An updated classification of retinal detachment with proliferative vitreoretinopathyQ67938098
Vitrectomy with silicone oil or sulfur hexafluoride gas in eyes with severe proliferative vitreoretinopathy: results of a randomized clinical trial. Silicone Study Report 1Q68140147
Vitrectomy with silicone oil or perfluoropropane gas in eyes with severe proliferative vitreoretinopathy: results of a randomized clinical trial. Silicone Study Report 2Q68140150
Definition and clinical importance of haplotypesQ28303291
Apoptosis: a review of programmed cell deathQ28305845
Intravitreal invading cells contribute to vitreal cytokine milieu in proliferative vitreoretinopathyQ28361127
The MDM2-p53 interaction.Q34288001
Proliferative vitreoretinopathy: risk factors and pathobiologyQ34572836
Inhibition of Mdm2 sensitizes human retinal pigment epithelial cells to apoptosisQ35027581
Targeting the p53 pathway in retinoblastoma with subconjunctival Nutlin-3aQ35050530
TP53 and MDM2 gene polymorphisms and risk of hepatocellular carcinoma among Italian patientsQ35206102
The MDM2 promoter polymorphism SNP309T-->G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neckQ35448964
MDM2, an introduction.Q35621040
Growth factors in retinal diseases: proliferative vitreoretinopathy, proliferative diabetic retinopathy, and retinal degenerationQ36015882
A single nucleotide polymorphism in the MDM2 gene: from a molecular and cellular explanation to clinical effectQ36182593
A novel function of p53: a gatekeeper of retinal detachmentQ36204186
The role of cytokines and trophic factors in epiretinal membranes: involvement of signal transduction in glial cellsQ36353215
Gene-environment interactions for complex traits: definitions, methodological requirements and challengesQ37181708
Onset and recurrence of proliferative vitreoretinopathy in various vitreoretinal diseaseQ37315556
Apoptosis and other cell death mechanisms after retinal detachment: implications for photoreceptor rescueQ37903606
Mechanisms of inflammation in proliferative vitreoretinopathy: from bench to bedside.Q38050745
Soluble apoptotic factors and adhesion molecules in rhegmatogenous retinal detachmentQ39775887
Effect of Smad7 gene overexpression on transforming growth factor beta-induced retinal pigment fibrosis in a proliferative vitreoretinopathy mouse modelQ40132971
Smad3 is required for dedifferentiation of retinal pigment epithelium following retinal detachment in miceQ40531865
The role of the p53 protein in the selective vulnerability of the inner retina to transient ischemiaQ40840934
Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li-Fraumeni syndromeQ42734774
A strong genetic association between the tumor necrosis factor locus and proliferative vitreoretinopathy: the retina 4 project.Q42955616
Growth factors in proliferative vitreoretinopathyQ43094987
Novel growth factors involved in the pathogenesis of proliferative vitreoretinopathyQ44052727
Ischemic preconditioning attenuates apoptotic cell death in the rat retinaQ44119136
HGF regulation of RPE proliferation in an IL-1beta/retinal hole-induced rabbit model of PVR.Q44261183
Elucidation of the pathogenic mechanism of rhegmatogenous retinal detachment with proliferative vitreoretinopathy by proteomic analysisQ44956270
Resources involved in managing retinal detachment complicated by proliferative vitreoretinopathyQ45173867
A randomized controlled trial of combined 5-fluorouracil and low-molecular-weight heparin in management of established proliferative vitreoretinopathyQ45175644
Causes of failure after repeat vitreoretinal surgery for recurrent proliferative vitreoretinopathy.Q45221978
Safety and efficacy assessment of chimeric ribozyme to proliferating cell nuclear antigen to prevent recurrence of proliferative vitreoretinopathy.Q46006684
Photoreceptor apoptosis in human retinal detachment.Q46419938
Interaction between surgical procedure for repairing retinal detachment and clinical risk factors for proliferative vitreoretinopathyQ46425636
The impact of tacrolimus on growth factors in experimental proliferative vitreoretinopathyQ46455363
Non-complicated retinal detachment management: variations in 4 years. Retina 1 project; report 1.Q46796771
Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells.Q47272769
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectrisk factorQ1475848
P304page(s)e82283
P577publication date2013-12-09
P1433published inPLOS OneQ564954
P1476titleThe T309G MDM2 gene polymorphism is a novel risk factor for proliferative vitreoretinopathy
P478volume8

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cites work (P2860)
Q92797443Blockade of MDM2 with inactive Cas9 prevents epithelial to mesenchymal transition in retinal pigment epithelial cells
Q55110302Comparison of SNP Genotypes Related to Proliferative Vitreoretinopathy (PVR) across Slovenian and European Subpopulations.
Q41848097Curcumin inhibits human retinal pigment epithelial cell proliferation
Q33991982Developments in Ocular Genetics: 2013 Annual Review
Q38701296Functional characterization of rs2229094 (T>C) polymorphism in the tumor necrosis factor locus and lymphotoxin alpha expression in human retina: the Retina 4 project
Q53226854Genetic association of single nucleotide polymorphisms in P53 pathway with gastric cancer risk in a Chinese Han population.
Q42380716Introduction of the MDM2 T309G Mutation in Primary Human Retinal Epithelial Cells Enhances Experimental Proliferative Vitreoretinopathy
Q39166181PDGFs and their receptors
Q37152868Prevention of Proliferative Vitreoretinopathy by Suppression of Phosphatidylinositol 5-Phosphate 4-Kinases.
Q39720539The Clustered, Regularly Interspaced, Short Palindromic Repeats-associated Endonuclease 9 (CRISPR/Cas9)-created MDM2 T309G Mutation Enhances Vitreous-induced Expression of MDM2 and Proliferation and Survival of Cells
Q34429965Vascular endothelial growth factor acts primarily via platelet-derived growth factor receptor α to promote proliferative vitreoretinopathy

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