Moderate alcohol induces stress proteins HSF1 and hsp70 and inhibits proinflammatory cytokines resulting in endotoxin tolerance

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Moderate alcohol induces stress proteins HSF1 and hsp70 and inhibits proinflammatory cytokines resulting in endotoxin tolerance is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1303468
P932PMC publication ID4325985
P698PubMed publication ID25024384
P5875ResearchGate publication ID263934079

P2093author name stringDonna Catalano
Pranoti Mandrekar
Melissa A Fulham
Aditya Ambade
Sujatha Muralidharan
Janhavee Deshpande
P2860cites workEmerging role of mast cells and macrophages in cardiovascular and metabolic diseasesQ26825467
Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation.Q27692108
Protein kinase A binds and activates heat shock factor 1Q28115287
mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesisQ28116279
Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1Q28118304
Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6Q28215984
TLR signalingQ28291637
Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1Q28343736
Glutamine-mediated dual regulation of heat shock transcription factor-1 activation and expressionQ28582486
Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expressionQ28609338
Pathogen recognition by the innate immune systemQ29615592
Ethanol inhibits LPS-induced signaling and modulates cytokine production in peritoneal macrophages in vivo in a model for binge drinkingQ33504859
C/EBP beta and C/EBP delta expression is elevated in the early phase of ethanol-induced hepatosteatosis in miceQ33552800
Consequences of alcohol consumption on host defenceQ33830107
Acute alcohol intake induces SOCS1 and SOCS3 and inhibits cytokine-induced STAT1 and STAT3 signaling in human monocytesQ33977596
Acute intake of moderate amounts of red wine or alcohol has no effect on the immune system of healthy men.Q34163590
Roles of the heat shock transcription factors in regulation of the heat shock response and beyondQ34245695
Cardiac macrophages and their role in ischaemic heart diseaseQ34402700
Alcohol, host defence and societyQ34576431
Suppression of the macrophage proteasome by ethanol impairs MHC class I antigen processing and presentationQ34602697
Ethanol, oxidative stress, and cytokine-induced liver cell injuryQ34683423
Ethanol abuse and the trauma patientQ35069204
Recent insights into the role of the innate immune system in the development of alcoholic liver disease.Q35216526
Ethanol induces oxidative stress in alveolar macrophages via upregulation of NADPH oxidasesQ35883952
Inhibition of heat shock protein (molecular weight 90 kDa) attenuates proinflammatory cytokines and prevents lipopolysaccharide-induced liver injury in mice.Q35930087
Induction of Bcl-3 by acute binge alcohol results in toll-like receptor 4/LPS toleranceQ36188860
Tolerance to microbial TLR ligands: molecular mechanisms and relevance to diseaseQ36486393
Brief alcohol exposure alters transcription in astrocytes via the heat shock pathway.Q36713124
Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cellsQ36848770
Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interactionQ36852932
Alcohol exposure regulates heat shock transcription factor binding and heat shock proteins 70 and 90 in monocytes and macrophages: implication for TNF-alpha regulationQ36938491
HSF1-mediated BAG3 expression attenuates apoptosis in 4-hydroxynonenal-treated colon cancer cells via stabilization of anti-apoptotic Bcl-2 proteinsQ37152837
Ethanol causes translocation of cAMP-dependent protein kinase catalytic subunit to the nucleusQ37332039
The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytesQ37354457
Inhibition of HSP70: a challenging anti-cancer strategyQ38023055
Mapping the crossroads of immune activation and cellular stress response pathwaysQ38098884
Ethanol induction of class I alcohol dehydrogenase expression in the rat occurs through alterations in CCAAT/enhancer binding proteins beta and gammaQ38363286
Induction of endotoxin tolerance in vivo inhibits activation of IRAK4 and increases negative regulators IRAK-M, SHIP-1, and A20.Q39753707
Heat shock factor 1 inhibits nuclear factor-kappaB nuclear binding activity during endotoxin tolerance and heat shockQ39947538
Negative regulation of toll-like receptor signaling by NF-kappaB p50 ubiquitination blockadeQ40098564
The inhibition of LPS-induced production of inflammatory cytokines by HSP70 involves inactivation of the NF-kappaB pathway but not the MAPK pathwaysQ40243061
Ethanol suppresses LPS-induced Toll-like receptor 4 clustering, reorganization of the actin cytoskeleton, and associated TNF-alpha productionQ40245495
Major stress protein Hsp70 interacts with NF-kB regulatory complex in human T-lymphoma cellsQ40425441
Bacterial endotoxin modifies heat shock factor-1 activity in RAW 264.7 cells: implications for TNF-alpha regulation during exposure to febrile range temperaturesQ40531863
Chronic ethanol increases lipopolysaccharide-stimulated Egr-1 expression in RAW 264.7 macrophages: contribution to enhanced tumor necrosis factor alpha productionQ40749420
A high affinity HSF-1 binding site in the 5'-untranslated region of the murine tumor necrosis factor-alpha gene is a transcriptional repressorQ40765080
Prolonged ethanol treatment enhances lipopolysaccharide/phorbol myristate acetate-induced tumor necrosis factor-alpha production in human monocytic cellsQ40814308
Tissue-specific upregulation of HSP72 in mice following short-term administration of alcoholQ41981417
Chronic alcohol consumption alters mammalian target of rapamycin (mTOR), reduces ribosomal p70s6 kinase and p4E-BP1 levels in mouse cerebral cortexQ42741995
The association between blood alcohol level and infectious complications among burn patientsQ44439285
Glutamine protects intestinal barrier function of colon epithelial cells from ethanol by modulating Hsp70 expressionQ44848731
Myocardial oxidative stress and toxicity induced by acute ethanol exposure in mice.Q44915449
Role of PKC and tyrosine kinase in ethanol-mediated inhibition of LPS-inducible nitric oxide synthaseQ47841291
Acute alcohol exposure exerts anti-inflammatory effects by inhibiting IkappaB kinase activity and p65 phosphorylation in human monocytes.Q51797026
Targeting heat shock factor 1 with a triazole nucleoside analog to elicit potent anticancer activity on drug-resistant pancreatic cancer.Q54327989
Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytesQ57375031
Transcriptional inhibition of endotoxin-induced monokine synthesis following heat shock in murine peritoneal macrophagesQ67579813
Down-regulation of tumor necrosis factor alpha activity by acute ethanol treatment in human peripheral blood monocytesQ70589853
Regulation of human monocyte functions by acute ethanol treatment: decreased tumor necrosis factor-alpha, interleukin-1 beta and elevated interleukin-10, and transforming growth factor-beta productionQ71672956
Inhibition of lipopolysaccharide-mediated NFkappaB activation by ethanol in human monocytesQ73142401
Wine modifies the effects of alcohol on immune cells of miceQ73763447
Hsp70 and Hsp40 chaperone activities in the cytoplasm and the nucleus of mammalian cellsQ73960036
Acute alcohol consumption attenuates interleukin-8 (IL-8) and monocyte chemoattractant peptide-1 (MCP-1) induction in response to ex vivo stimulationQ74610719
Monocytes, alcohol use, and altered immunityQ77198970
Over-expression of hsp-70 inhibits bacterial lipopolysaccharide-induced production of cytokines in human monocyte-derived macrophagesQ77742652
Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytesQ80058051
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectendotoxinsQ319997
P304page(s)1975-1987
P577publication date2014-07-14
P1433published inJournal of ImmunologyQ3521441
P1476titleModerate alcohol induces stress proteins HSF1 and hsp70 and inhibits proinflammatory cytokines resulting in endotoxin tolerance
P478volume193

Reverse relations

cites work (P2860)
Q33634052Adolescent Ethanol Exposure Leads to Stimulus-Specific Changes in Cytokine Reactivity and Hypothalamic-Pituitary-Adrenal Axis Sensitivity in Adulthood
Q47786445Alcohol Reduces Arterial Remodeling by Inhibiting Sonic Hedgehog-Stimulated Stem Cell Antigen-1 Positive Progenitor Stem Cell Expansion
Q64999497Chronic heavy drinking drives distinct transcriptional and epigenetic changes in splenic macrophages.
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Q54960640Drug- and/or trauma-induced hyperthermia? Characterization of HSP70 and myoglobin expression.
Q40073627Effects of Binge-Like Ethanol Exposure During Adolescence on the Febrile Response in Rats.
Q40290541Enhanced resistance against Vibrio harveyi infection by carvacrol and its association with the induction of heat shock protein 72 in gnotobiotic Artemia franciscana
Q55190074Heat shock protein 70 protects mouse against post-infection irritable bowel syndrome via up-regulating intestinal γδ T cell's Th17 response.
Q33682125Heat shock protein70 is implicated in modulating NF-κB activation in alveolar macrophages of patients with active pulmonary tuberculosis
Q90012226Heterogeneous macrophages: Supersensors of exogenous inducing factors
Q87790172Human Binge Alcohol Intake Inhibits TLR4-MyD88 and TLR4-TRIF Responses but Not the TLR3-TRIF Pathway: HspA1A and PP1 Play Selective Regulatory Roles
Q38830540Immune activation and neuroinflammation in alcohol use and HIV infection: evidence for shared mechanisms
Q48226480Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease
Q37015781Opposing effects of alcohol on the immune system
Q36322355Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling.
Q36106637Possible Contribution of Zerumbone-Induced Proteo-Stress to Its Anti-Inflammatory Functions via the Activation of Heat Shock Factor 1.
Q41087764Preinduction of heat shock protein 70 protects mice against post-infection irritable bowel syndrome via NF-κB and NOS/NO signaling pathways
Q38759448Systemic inflammatory response syndrome following burns is mediated by brain natriuretic peptide/natriuretic peptide A receptor-induced shock factor 1 signaling pathway
Q37520958Ten-year alcohol consumption typologies and trajectories of C-reactive protein, interleukin-6 and interleukin-1 receptor antagonist over the following 12 years: a prospective cohort study.

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