The single RBP-Jkappa site within the LANA promoter is crucial for establishing Kaposi's sarcoma-associated herpesvirus latency during primary infection

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The single RBP-Jkappa site within the LANA promoter is crucial for establishing Kaposi's sarcoma-associated herpesvirus latency during primary infection is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.02608-10
P932PMC publication ID3126528
P698PubMed publication ID21507979

P50authorSubhash VermaQ57951657
Erle S RobertsonQ88590600
P2093author name stringJie Lu
Qiliang Cai
P2860cites workHuman herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cellsQ24527215
Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies.Q24531182
Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirusQ24561400
Identification of direct transcriptional targets of the Kaposi's sarcoma-associated herpesvirus Rta lytic switch protein by conditional nuclear localizationQ24648127
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)Q24650427
The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigenQ24672438
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomesQ24673761
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcomaQ28242984
Early events associated with infection of Epstein-Barr virus infection of primary B-cellsQ28476230
A highly efficient recombineering-based method for generating conditional knockout mutationsQ29615157
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's diseaseQ29619158
EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressorsQ33261811
K13 blocks KSHV lytic replication and deregulates vIL6 and hIL6 expression: a model of lytic replication induced clonal selection in viral oncogenesisQ33303677
Human herpesvirus replication and abnormal CD8+ T cell activation and low CD4+ T cell counts in antiretroviral-suppressed HIV-infected patientsQ33432729
Non-human primate model of Kaposi's sarcoma-associated herpesvirus infectionQ33508240
The role of HHV-8 in Kaposi's sarcomaQ33644229
Kinetics of Kaposi's sarcoma-associated herpesvirus gene expressionQ33653424
Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jkappa, the major downstream effector of the Notch signaling pathwayQ33737793
Transcription program of human herpesvirus 8 (kaposi's sarcoma-associated herpesvirus).Q33841257
Induction of Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen by the lytic transactivator RTA: a novel mechanism for establishment of latencyQ33843211
The latency-associated nuclear antigen encoded by Kaposi's sarcoma-associated herpesvirus activates two major essential Epstein-Barr virus latent promotersQ33845947
DNA binding and modulation of gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirusQ33853499
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activityQ33922095
Notch signaling: the core pathway and its posttranslational regulationQ34017623
Transcription mapping of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome in a body cavity-based lymphoma cell line (BC-1)Q34069105
Convergence of Kaposi's Sarcoma-Associated Herpesvirus Reactivation with Epstein-Barr Virus Latency and Cellular Growth Mediated by the Notch Signaling Pathway in Coinfected CellsQ34178226
Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virus-mediated control of latencyQ34194120
Charting latency transcripts in Kaposi's sarcoma-associated herpesvirus by whole-genome real-time quantitative PCRQ34340317
A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency.Q34531461
Virologic, hematologic, and immunologic risk factors for classic Kaposi sarcomaQ34571278
Acetylation of the latency-associated nuclear antigen regulates repression of Kaposi's sarcoma-associated herpesvirus lytic transcription.Q34648229
Kaposi's sarcoma-associated herpesvirus infection prior to onset of Kaposi's sarcomaQ34735185
Global changes in Kaposi's sarcoma-associated virus gene expression patterns following expression of a tetracycline-inducible Rta transactivatorQ34782463
Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induces Expression of the Helix-Loop-Helix Protein Id-1 in Human Endothelial CellsQ34976840
Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANAQ35080754
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus manipulates the activity of glycogen synthase kinase-3betaQ35104781
Accumulation of heterochromatin components on the terminal repeat sequence of Kaposi's sarcoma-associated herpesvirus mediated by the latency-associated nuclear antigenQ35123088
Kaposi's sarcoma-associated herpesvirus LANA-1 interacts with the short variant of BRD4 and releases cells from a BRD4- and BRD2/RING3-induced G1 cell cycle arrestQ35139294
Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signalingQ35168476
Functional characterization of Kaposi's sarcoma-associated herpesvirus ORF45 by bacterial artificial chromosome-based mutagenesisQ35185925
The Kaposi's sarcoma-associated herpesvirus LANA protein stabilizes and activates c-MycQ36099076
Chromatin remodeling of the Kaposi's sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latencyQ36538689
Kaposi's sarcoma-associated herpesvirus latent gene vFLIP inhibits viral lytic replication through NF-kappaB-mediated suppression of the AP-1 pathway: a novel mechanism of virus control of latencyQ36540187
KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptorQ36591375
Characterization of the interaction between latency-associated nuclear antigen and glycogen synthase kinase 3betaQ37204595
The Notch signaling pathway: transcriptional regulation at Notch target genesQ37376057
Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcomaQ37535731
Kaposi's sarcoma-associated herpesvirus latent and lytic gene expression as revealed by DNA arraysQ38305362
Wide-scale use of Notch signaling factor CSL/RBP-Jkappa in RTA-mediated activation of Kaposi's sarcoma-associated herpesvirus lytic genesQ38348963
Evaluation of the lytic origins of replication of Kaposi's sarcoma-associated virus/human herpesvirus 8 in the context of the viral genomeQ38760706
A new primary effusion lymphoma-derived cell line yields a highly infectious Kaposi's sarcoma herpesvirus-containing supernatantQ39539612
Epstein-Barr Virus nuclear antigen 1 (EBNA1) confers resistance to apoptosis in EBV-positive B-lymphoma cells through up-regulation of survivinQ39629572
Kaposi's sarcoma-associated herpesvirus inhibits interleukin-4-mediated STAT6 phosphorylation to regulate apoptosis and maintain latencyQ39665994
Characterization of entry and infection of monocytic THP-1 cells by Kaposi's sarcoma associated herpesvirus (KSHV): role of heparan sulfate, DC-SIGN, integrins and signalingQ39673166
Bub1 and CENP-F can contribute to Kaposi's sarcoma-associated herpesvirus genome persistence by targeting LANA to kinetochoresQ39675686
Efficient infection by a recombinant Kaposi's sarcoma-associated herpesvirus cloned in a bacterial artificial chromosome: application for genetic analysisQ39683622
Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 K-bZIP modulates latency-associated nuclear protein-mediated suppression of lytic origin-dependent DNA synthesisQ39833695
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (KSHV) upregulates survivin expression in KSHV-Associated B-lymphoma cells and contributes to their proliferationQ39852047
The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway.Q39860135
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cellsQ39877852
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1.Q39992257
Human herpesvirus 8 infects and replicates in primary cultures of activated B lymphocytes through DC-SIGN.Q40002946
Gamma delta+ T cells involvement in viral immune control of chronic human herpesvirus 8 infectionQ40010164
Overexpression of the kaposi's sarcoma-associated herpesvirus transactivator K-Rta can complement a K-bZIP deletion BACmid and yields an enhanced growth phenotypeQ40072559
A potential alpha-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1alpha in normoxiaQ40106826
Deregulation of c-Myc in primary effusion lymphoma by Kaposi's sarcoma herpesvirus latency-associated nuclear antigenQ40169138
Ets-1-dependent expression of vascular endothelial growth factor receptors is activated by latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus through interaction with DaxxQ40252446
Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen induces chromosomal instability through inhibition of p53 functionQ40335991
Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis.Q40364647
New viruses shake old paradigmsQ40364721
Inhibiting primary effusion lymphoma by lentiviral vectors encoding short hairpin RNA.Q40486158
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus modulates cellular gene expression and protects lymphoid cells from p16 INK4A-induced cell cycle arrestQ40496132
RBP-J (CSL) is essential for activation of the K14/vGPCR promoter of Kaposi's sarcoma-associated herpesvirus by the lytic switch protein RTAQ40546002
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus transactivates the telomerase reverse transcriptase promoterQ40811288
In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequencesQ40971183
Human herpesvirus-8: detection of novel herpesvirus-like DNA sequences in Kaposi's sarcoma and other lesionsQ41126577
Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) in primary effusion lymphoma: ultrastructural demonstration of herpesvirus in lymphoma cellsQ41191622
Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in cultureQ41225141
KSHV and Kaposi's sarcoma: the end of the beginning?Q41622722
Regulation of the interaction between glycogen synthase kinase 3 and the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigenQ41849965
Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 alpha to upregulate RTA expression during hypoxia: Latency control under low oxygen conditionsQ42049779
A Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50 deletion mutant is defective for reactivation of latent virus and DNA replicationQ42150768
Infection of primary human tonsillar lymphoid cells by KSHV reveals frequent but abortive infection of T cellsQ42710003
Cytomegalovirus and human herpesvirus 8 DNA detection in peripheral blood monocytic cells of AIDS patients: correlations with the presence of Kaposi's sarcoma and CMV diseaseQ45246332
Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?Q45749153
Propagating Kaposi's sarcoma-associated herpesvirusQ71957790
Latent and lytic HHV-8 mRNA expression in PBMCs and Kaposi's sarcoma skin biopsies of AIDS Kaposi's sarcoma patientsQ73497577
Evaluation of the human herpesvirus 8 DNA load in blood and Kaposi's sarcoma skin lesions from AIDS patients on highly active antiretroviral therapyQ74344820
Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R proteinQ77760836
Relationship between human herpesvirus 8 loads and disease stage in classic Kaposi sarcoma patientsQ80086361
P433issue13
P407language of work or nameEnglishQ1860
P304page(s)6148-6161
P577publication date2011-04-20
P1433published inJournal of VirologyQ1251128
P1476titleThe single RBP-Jkappa site within the LANA promoter is crucial for establishing Kaposi's sarcoma-associated herpesvirus latency during primary infection
P478volume85