C3 rho-inhibitor for targeted pharmacological manipulation of osteoclast-like cells

scientific article

C3 rho-inhibitor for targeted pharmacological manipulation of osteoclast-like cells is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...885695T
P356DOI10.1371/JOURNAL.PONE.0085695
P8608Fatcat IDrelease_xg44mtfk4javrcapxbpaerprqm
P932PMC publication ID3874027
P698PubMed publication ID24386487
P5875ResearchGate publication ID259567951

P50authorAnita IgnatiusQ40458069
P2093author name stringLudwika Kreja
Holger Barth
Christina Förtsch
Christian Zwerger
Lydia Dmochewitz
Andrea Tautzenberger
P2860cites workThe small GTP-binding protein, rho p21, is involved in bone resorption by regulating cytoskeletal organization in osteoclasts.Q52509359
Regulation of Actin Ring Formation by Rho GTPases in OsteoclastsQ57372361
Purification and characterization of an ADP-ribosyltransferase produced by Clostridium limosumQ68127915
Inhibition of the osteoclast V-ATPase by small interfering RNAsQ81098185
Local bisphosphonate release versus hydroxyapatite coating for stainless steel screw fixation in rat tibiaeQ83145344
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligandQ24653311
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
A recombinant fusion toxin based on enzymatic inactive C3bot1 selectively targets macrophagesQ28485203
Selective and specific internalization of clostridial C3 ADP-ribosyltransferases into macrophages and monocytesQ33511332
Expression profile of RhoGTPases and RhoGEFs during RANKL-stimulated osteoclastogenesis: identification of essential genes in osteoclastsQ34561453
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assayQ34661407
Rho-modifying C3-like ADP-ribosyltransferasesQ35889810
C3 exoenzymes, novel insights into structure and action of Rho-ADP-ribosylating toxinsQ36674045
Binary actin-ADP-ribosylating toxins and their use as molecular Trojan horses for drug delivery into eukaryotic cellsQ37090070
Actin cytoskeletal organisation in osteoclasts: a model to decipher transmigration and matrix degradationQ37092466
Osteoclastogenesis--current knowledge and future perspectives.Q37272396
New insights into the mode of action of the actin ADP-ribosylating virulence factors Salmonella enterica SpvB and Clostridium botulinum C2 toxinQ37830120
The regulation of osteoclast function and bone resorption by small GTPasesQ37903263
Streptavidin-conjugated C3 protein mediates the delivery of mono-biotinylated RNAse A into macrophagesQ39334719
The N-terminal part of the enzyme component (C2I) of the binary Clostridium botulinum C2 toxin interacts with the binding component C2II and functions as a carrier system for a Rho ADP-ribosylating C3-like fusion toxinQ39570552
Studies on the active-site structure of C3-like exoenzymes: involvement of glutamic acid in catalysis of ADP-ribosylationQ40926348
Selective local delivery of RANK siRNA to bone phagocytes using bone augmentation biomaterialsQ42052780
ADP-ribosylation of a 21-24 kDa eukaryotic protein(s) by C3, a novel botulinum ADP-ribosyltransferase, is regulated by guanine nucleotideQ42164610
Recombinant streptavidin-C3bot for delivery of proteins into macrophagesQ46622404
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)e85695
P577publication date2013-12-27
P1433published inPLOS OneQ564954
P1476titleC3 rho-inhibitor for targeted pharmacological manipulation of osteoclast-like cells
P478volume8

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cites work (P2860)
Q52886432A Supramolecular Approach toward Bioinspired PAMAM-Dendronized Fusion Toxins.
Q38891006Biology of Paenibacillus larvae, a deadly pathogen of honey bee larvae
Q62117793Boosting Antitumor Drug Efficacy with Chemically Engineered Multidomain Proteins
Q35121306C3larvin toxin, an ADP-ribosyltransferase from Paenibacillus larvae
Q90351944Cellular Mechanotransduction: From Tension to Function
Q26801630Clostridial C3 Toxins Target Monocytes/Macrophages and Modulate Their Functions
Q91105774Prominin-1 Modulates Rho/ROCK-Mediated Membrane Morphology and Calcium-Dependent Intracellular Chloride Flux
Q47780798Rho-inhibiting C2IN-C3 fusion toxin inhibits chemotactic recruitment of human monocytes ex vivo and in mice in vivo
Q47863891Spatiotemporally Controlled Release of Rho-Inhibiting C3 Toxin from a Protein-DNA Hybrid Hydrogel for Targeted Inhibition of Osteoclast Formation and Activity

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