| scholarly article | Q13442814 |
| P2093 | author name string | Wanjin Hong | |
| Xin Wang | |||
| Guojun Bu | |||
| Huaxi Xu | |||
| Timothy Huang | |||
| Yingjun Zhao | |||
| Yun-wu Zhang | |||
| Robert C Thompson | |||
| Qiuyang Zheng | |||
| P2860 | cites work | Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice | Q22242267 |
| Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing | Q24290265 | ||
| Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation | Q24294891 | ||
| SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane | Q24297153 | ||
| SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors | Q24304190 | ||
| A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein | Q24312803 | ||
| Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo | Q24315707 | ||
| Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease | Q24316501 | ||
| TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity | Q24321405 | ||
| A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport | Q24337927 | ||
| Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing | Q24338519 | ||
| Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate receptor 2C (NR2C) | Q24339429 | ||
| CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production | Q24523660 | ||
| Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation | Q24541447 | ||
| Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation | Q24654821 | ||
| Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27 | Q27667305 | ||
| Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases | Q27667515 | ||
| Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1 | Q28139001 | ||
| Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway | Q28252623 | ||
| A nine-transmembrane domain topology for presenilin 1 | Q28263814 | ||
| Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain | Q28273268 | ||
| New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting | Q28286252 | ||
| Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling | Q28292379 | ||
| Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD) | Q28568146 | ||
| A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction | Q28572476 | ||
| A developmentally regulated and psychostimulant-inducible novel rat gene mrt1 encoding PDZ-PX proteins isolated in the neocortex | Q28579863 | ||
| APP processing and synaptic function | Q29615873 | ||
| A role for sorting nexin 27 in AMPA receptor trafficking. | Q30571548 | ||
| Stereological assessment of vulnerability of immunocytochemically identified striatal and hippocampal neurons after global cerebral ischemia in rats | Q30713724 | ||
| Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes | Q33206144 | ||
| Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons | Q33579072 | ||
| APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos | Q33894454 | ||
| Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice | Q34076162 | ||
| Sorting nexin 27 regulation of G protein-gated inwardly rectifying K⁺ channels attenuates in vivo cocaine response | Q34076448 | ||
| A common enzyme connects notch signaling and Alzheimer's disease | Q34088470 | ||
| Model-guided microarray implicates the retromer complex in Alzheimer's disease | Q34471199 | ||
| γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2 | Q34648460 | ||
| VPS35 haploinsufficiency increases Alzheimer's disease neuropathology. | Q35670733 | ||
| Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation | Q36105134 | ||
| A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation | Q36587936 | ||
| β-arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology | Q36655033 | ||
| Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. | Q37548268 | ||
| Novel research horizons for presenilins and γ-secretases in cell biology and disease | Q37770248 | ||
| The genetics of Alzheimer disease: back to the future | Q37801081 | ||
| Function and dysfunction of presenilin | Q38150941 | ||
| β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease | Q39234405 | ||
| Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes | Q39262801 | ||
| PPARγ co-activator-1α (PGC-1α) reduces amyloid-β generation through a PPARγ-dependent mechanism | Q39584769 | ||
| Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway | Q39733430 | ||
| The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex | Q41062110 | ||
| Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain | Q44405189 | ||
| Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis | Q48217048 | ||
| Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. | Q53274559 | ||
| Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation. | Q53383103 | ||
| Endosomal sorting and signalling: an emerging role for sorting nexins. | Q55050015 | ||
| A novel transmembrane topology of presenilin based on reconciling experimental and computational evidence | Q57444184 | ||
| P433 | issue | 3 | |
| P304 | page(s) | 1023-1033 | |
| P577 | publication date | 2014-10-23 | |
| P1433 | published in | Cell Reports | Q5058165 |
| P1476 | title | Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity | |
| P478 | volume | 9 |
| Q26798983 | A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome |
| Q27727997 | A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex |
| Q37021365 | A role for novel lipid interactions in the dynamic recruitment of SNX27 to the T-cell immune synapse |
| Q47878052 | Alzheimer disease: modeling an Aβ-centered biological network |
| Q48170739 | Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing. |
| Q45300233 | Comparison of Efficacy of Preventive and Therapeutic Vaccines Targeting the N Terminus of β-Amyloid in an Animal Model of Alzheimer's Disease |
| Q28080576 | Complex regulation of γ-secretase: from obligatory to modulatory subunits |
| Q60956702 | Deletion Promotes Recovery From Spinal Cord Injury by Neuroprotection and Reduces Macrophage/Microglia Proliferation |
| Q38865366 | Dementia in Down's syndrome |
| Q26777254 | Dissecting Alzheimer disease in Down syndrome using mouse models |
| Q47875216 | Dysregulation of Rab5-Mediated Endocytic Pathways in Alzheimer's Disease |
| Q43405940 | ER-associated degradation regulates Alzheimer's amyloid pathology and memory function by modulating γ-secretase activity |
| Q36332872 | Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP |
| Q50133968 | Overexpression of SNX3 Decreases Amyloid-β Peptide Production by Reducing Internalization of Amyloid Precursor Protein |
| Q47551317 | Pathophysiological Role of Purines and Pyrimidines in Neurodevelopment: Unveiling New Pharmacological Approaches to Congenital Brain Diseases |
| Q90196986 | Regulation of the endosomal SNX27-retromer by OTULIN |
| Q26766012 | Role of the Retromer Complex in Neurodegenerative Diseases |
| Q41137458 | SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation |
| Q37504966 | SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis |
| Q37127871 | SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein. |
| Q39704371 | SNX27, a protein involved in down syndrome, regulates GPR17 trafficking and oligodendrocyte differentiation |
| Q36798625 | Sorting nexin 27 couples PTHR trafficking to retromer for signal regulation in osteoblasts during bone growth |
| Q48182700 | Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse |
| Q36565309 | Sorting nexin 27 interacts with Fzd7 and mediates Wnt signalling |
| Q51764852 | TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. |
| Q52327330 | The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases. |
| Q47953822 | mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia |
| Q38751069 | miR-98-5p Acts as a Target for Alzheimer's Disease by Regulating Aβ Production Through Modulating SNX6 Expression |
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