Genetic absence of nNOS worsens fetal alcohol effects in mice. II: microencephaly and neuronal losses

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Genetic absence of nNOS worsens fetal alcohol effects in mice. II: microencephaly and neuronal losses is …
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scholarly articleQ13442814

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P356DOI10.1111/ACER.12615
P932PMC publication ID4331271
P698PubMed publication ID25664654

P2093author name stringBahri Karacay
Daniel J Bonthius
Jo Mahoney
Jeffrey Plume
P2860cites workStructural organization of the human neuronal nitric oxide synthase gene (NOS1).Q42674895
FGF-2, NGF and IGF-1, but not BDNF, utilize a nitric oxide pathway to signal neurotrophic and neuroprotective effects against alcohol toxicity in cerebellar granule cell culturesQ44275894
The NO-cGMP-PKG pathway plays an essential role in the acquisition of ethanol resistance by cerebellar granule neuronsQ44786666
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Association between Parkinson's disease and polymorphisms in the nNOS and iNOS genes in a community-based case-control studyQ48422898
Alcohol-induced Purkinje cell loss depends on developmental timing of alcohol exposure and correlates with motor performanceQ48451635
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A single dose of ethanol suppresses rat embryo development in vivo.Q52092278
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Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brainQ28511112
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Genetic absence of nNOS worsens fetal alcohol effects in mice. I: behavioral deficitsQ30392108
Permanent neuronal deficits in rats exposed to alcohol during the brain growth spurtQ30447961
Reduced seizure threshold and hippocampal cell loss in rats exposed to alcohol during the brain growth spurtQ31993808
Alcohol exposure during the brain growth spurt promotes hippocampal seizures, rapid kindling, and spreading depressionQ33182041
Deficiency of neuronal nitric oxide synthase (nNOS) worsens alcohol-induced microencephaly and neuronal loss in developing miceQ33184394
Use of frozen sections to determine neuronal number in the murine hippocampus and neocortex using the optical disector and optical fractionatorQ33208587
Severe alcohol-induced neuronal deficits in the hippocampus and neocortex of neonatal mice genetically deficient for neuronal nitric oxide synthase (nNOS).Q33257696
The protective effect of neuronal nitric oxide synthase (nNOS) against alcohol toxicity depends upon the NO-cGMP-PKG pathway and NF-kappaB.Q33372643
Nitric oxide utilizes NF-kappaB to signal its neuroprotective effect against alcohol toxicityQ33398878
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Fetal alcohol syndrome in twins of alcoholic mothers: concordance of diagnosis and IQ.Q34061128
Adenylyl cyclases types 1 and 8 promote pro-survival pathways after ethanol exposure in the neonatal brainQ34109917
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Magnetic resonance imaging outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disordersQ34223287
Changes in the total number of dentate granule cells in juvenile and adult rats: a correlated volumetric and 3H-thymidine autoradiographic studyQ34278630
Tissue plasminogen activator is required for the development of fetal alcohol syndrome in mice.Q34720486
Genetic evidence for the neuronal nitric oxide synthase gene (NOS1) as a susceptibility locus for infantile pyloric stenosisQ35881392
Genetic polymorphisms: impact on the risk of fetal alcohol spectrum disordersQ36078197
Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD.Q37597659
The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis.Q39540612
An update on incidence of FAS: FAS is not an equal opportunity birth defectQ40416343
Regulation of nerve growth factor release by nitric oxide through cyclic GMP pathway in cortical glial cellsQ40885341
Cell death in the development of the lateral motor column of the chick embryoQ41068408
Early postnatal alcohol exposure acutely and permanently reduces the number of granule cells and mitral cells in the rat olfactory bulb: a stereological studyQ41099997
Stimulation of the cAMP pathway protects cultured cerebellar granule neurons against alcohol-induced cell death by activating the neuronal nitric oxide synthase (nNOS) geneQ41877327
A single exposure to alcohol during brain development induces microencephaly and neuronal losses in genetically susceptible mice, but not in wild type miceQ41937930
Liquid diets reduce cell proliferation but not neurogenesis in the adult rat hippocampus.Q42445307
P433issue2
P921main subjectfetal alcohol effectsQ5820163
P304page(s)221-231
P577publication date2015-02-09
P1433published inAlcoholism: Clinical and Experimental ResearchQ4713331
P1476titleGenetic absence of nNOS worsens fetal alcohol effects in mice. II: microencephaly and neuronal losses
P478volume39