The relative magnitude of transgene-specific adaptive immune responses induced by human and chimpanzee adenovirus vectors differs between laboratory animals and a target species

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The relative magnitude of transgene-specific adaptive immune responses induced by human and chimpanzee adenovirus vectors differs between laboratory animals and a target species is …
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scholarly articleQ13442814

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P356DOI10.1016/J.VACCINE.2015.01.042
P932PMC publication ID4331283
P698PubMed publication ID25629523
P5875ResearchGate publication ID271598107

P50authorAdrian V. S. HillQ22278197
Sarah GilbertQ30513802
Alexandra SpencerQ43158244
Matthew G. CottinghamQ55465134
Efrain GuzmanQ56841961
Bryan CharlestonQ61162596
P2093author name stringMatthew D J Dicks
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Differential effects of viral vectors on migratory afferent lymph dendritic cells in vitro predict enhanced immunogenicity in vivo.Q35192675
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Comparative analysis of the magnitude, quality, phenotype, and protective capacity of simian immunodeficiency virus gag-specific CD8+ T cells following human-, simian-, and chimpanzee-derived recombinant adenoviral vector immunizationQ36674446
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Increased efficacy of an adenovirus-vectored foot-and-mouth disease capsid subunit vaccine expressing nonstructural protein 2B is associated with a specific T cell responseQ39452853
Expression of tak1 and tram induces synergistic pro-inflammatory signalling and adjuvants DNA vaccinesQ39818388
Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium bergheiQ40125164
Chimpanzee-origin adenovirus vectors as vaccine carriers.Q40345527
Rapid protection of cattle from direct challenge with foot-and-mouth disease virus (FMDV) by a single inoculation with an adenovirus-vectored FMDV subunit vaccine.Q40422822
Induction of CD8+ T cells to an HIV-1 antigen through a prime boost regimen with heterologous E1-deleted adenoviral vaccine carriers.Q40609257
Immune responses induced in cattle by vaccination with a recombinant adenovirus expressing Mycobacterial antigen 85A and Mycobacterium bovis BCGQ41908519
Clinical assessment of a novel recombinant simian adenovirus ChAdOx1 as a vectored vaccine expressing conserved Influenza A antigensQ42003390
Comparison of the immunogenicity and protection against bovine tuberculosis following immunization by BCG-priming and boosting with adenovirus or protein based vaccinesQ42253606
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CD8+ T-cell expansion and maintenance after recombinant adenovirus immunization rely upon cooperation between hematopoietic and nonhematopoietic antigen-presenting cells.Q51030167
The CD8+ T cell population elicited by recombinant adenovirus displays a novel partially exhausted phenotype associated with prolonged antigen presentation that nonetheless provides long-term immunity.Q51986133
Functional properties and lineage relationship of CD8+ T cell subsets identified by expression of IL-7 receptor alpha and CD62L.Q51988630
Type I interferon inhibits antibody responses induced by a chimpanzee adenovirus vector.Q52840563
The immunogenicity of adenovirus vectors limits the multispecificity of CD8 T-cell responses to vector-encoded transgenic antigensQ64376607
Time-dependent biodistribution and transgene expression of a recombinant human adenovirus serotype 5-luciferase vector as a surrogate for rAd5-FMDV vaccines in cattleQ64378803
Mucosal immunization of calves with recombinant bovine adenovirus-3: induction of protective immunity to bovine herpesvirus-1Q64381481
The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12Q64383973
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectAdenoviridaeQ193447
chimpanzeeQ4126704
P304page(s)1121-1128
P577publication date2015-01-25
P1433published inVaccineQ7907941
P1476titleThe relative magnitude of transgene-specific adaptive immune responses induced by human and chimpanzee adenovirus vectors differs between laboratory animals and a target species
P478volume33

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cites work (P2860)
Q38814885Adenoviral vector-based strategies against infectious disease and cancer
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Q54234703Identification and Evaluation of Novel Protective Antigens for the Development of a Candidate TB Subunit Vaccine.
Q36369598Improvement of BCG protective efficacy with a novel chimpanzee adenovirus and a modified vaccinia Ankara virus both expressing Ag85A
Q42150824Induction of CD8(+) T cell responses and protective efficacy following microneedle-mediated delivery of a live adenovirus-vectored malaria vaccine
Q54531277Simian adenoviruses as vaccine vectors.
Q42107571Strain-dependent and distinctive T-cell responses to HIV antigens following immunisation of mice with differing chimpanzee adenovirus vaccine vectors
Q92622099Targeting Antigen to the Surface of EVs Improves the In Vivo Immunogenicity of Human and Non-human Adenoviral Vaccines in Mice
Q100466517Technological approaches to streamline vaccination schedules, progressing towards single-dose vaccines
Q40574579Transduction of skin-migrating dendritic cells by human adenovirus 5 occurs via an actin-dependent phagocytic pathway

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