Injection of a soluble fragment of neural agrin (NT-1654) considerably improves the muscle pathology caused by the disassembly of the neuromuscular junction

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Injection of a soluble fragment of neural agrin (NT-1654) considerably improves the muscle pathology caused by the disassembly of the neuromuscular junction is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...988739H
P356DOI10.1371/JOURNAL.PONE.0088739
P932PMC publication ID3919806
P698PubMed publication ID24520420
P5875ResearchGate publication ID260150669

P2093author name stringMarkus A Ruegg
Shuo Lin
Filippo Oliveri
Stefan Hettwer
Monika Haubitz
Jan W Vrijbloed
Ruggero G Fariello
Stefan Kucsera
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The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivoQ28280767
Defective neuromuscular synaptogenesis in agrin-deficient mutant miceQ28280786
Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardationQ28507760
Agrin and synaptic laminin are required to maintain adult neuromuscular junctionsQ28511069
Alternatively spliced isoforms of nerve- and muscle-derived agrin: their roles at the neuromuscular junctionQ28513062
Neurotrypsin cleaves agrin locally at the synapseQ28513643
LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junctionQ28592974
Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFPQ29547505
Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant miceQ30482979
Sustained ocular hypertension induces dendritic degeneration of mouse retinal ganglion cells that depends on cell type and locationQ30534999
Remodeling of the neuromuscular junction precedes sarcopenia related alterations in myofibersQ33788155
Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exerciseQ34093370
Defects in neuromuscular junction remodelling in the Smn(2B/-) mouse model of spinal muscular atrophy.Q50786048
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MuSK levels differ between adult skeletal muscles and influence postsynaptic plasticityQ61855429
DAB cytochemistry: artifact problems in its current usesQ71303690
Activation of muscle-specific receptor tyrosine kinase and binding to dystroglycan are regulated by alternative mRNA splicing of agrinQ79165764
Denervation produces different single fiber phenotypes in fast- and slow-twitch hindlimb muscles of the ratQ83149945
Elevated levels of a C-terminal agrin fragment identifies a new subset of sarcopenia patientsQ83703672
Destabilization of the neuromuscular junction by proteolytic cleavage of agrin results in precocious sarcopeniaQ84874688
The agrin gene codes for a family of basal lamina proteins that differ in function and distributionQ34234963
New insights into the roles of agrinQ35097331
A valid mouse model of AGRIN-associated congenital myasthenic syndrome.Q35532941
Effects of aging on muscle fibre type and sizeQ35907563
Mitochondrial signaling contributes to disuse muscle atrophy.Q36114865
Distinct roles of muscle and motoneuron LRP4 in neuromuscular junction formationQ36173668
Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active siteQ36382434
Localization of acetylcholine receptor by 125I-labeled alpha-bungarotoxin binding at mouse motor endplatesQ36517854
Skeletal Muscle in Motor Neuron Diseases: Therapeutic Target and Delivery Route for Potential TreatmentsQ36805205
The role of MuSK in synapse formation and neuromuscular diseaseQ38103527
Koelle's copper thiocholine method performed with a low-pH phosphate buffer, followed by osmification of the precipitate: revival of two abandoned proceduresQ39239602
Specific proteolytic cleavage of agrin regulates maturation of the neuromuscular junctionQ39639185
Increasing MuSK activity delays denervation and improves motor function in ALS miceQ41877091
Neuromuscular junction protection for the potential treatment of amyotrophic lateral sclerosisQ42285046
Autoantibodies in myasthenia gravisQ43751539
Three myosin heavy chain isoforms in type 2 skeletal muscle fibres.Q44241210
Expression of mouse agrin in normal, denervated and dystrophic muscleQ44473154
The effect of in vitro formation of acetylcholine receptor (AChR) clusters in engineered muscle fibers on subsequent innervation of constructs in vivoQ46488107
Purification and enzymological characterization of murine neurotrypsinQ46520674
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectneuromuscular junctionQ776995
P304page(s)e88739
P577publication date2014-02-10
P1433published inPLOS OneQ564954
P1476titleInjection of a soluble fragment of neural agrin (NT-1654) considerably improves the muscle pathology caused by the disassembly of the neuromuscular junction
P478volume9

Reverse relations

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