Scarcity or absence of humoral immune responses in the plasma and cervicovaginal lavage fluids of heavily HIV-1-exposed but persistently seronegative women

scientific article

Scarcity or absence of humoral immune responses in the plasma and cervicovaginal lavage fluids of heavily HIV-1-exposed but persistently seronegative women is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1089/AID.2010.0169
P8608Fatcat IDrelease_3txs44akxfffxmooxzer6bmlzm
P932PMC publication ID3132065
P698PubMed publication ID21091128
P5875ResearchGate publication ID49622416

P50authorHerman StaatsQ42428433
Lucia LopalcoQ43112481
Michael HoelscherQ72527439
Leonard MabokoQ72529045
Gabriele RiednerQ76571794
Pamela A KozlowskiQ88438362
P2093author name stringJiri Mestecky
Rose Kulhavy
Zina Moldoveanu
Claudia Pastori
Peter F Wright
Rashada C Alexander
Terri Wrinn
Yuwei Zhu
P2860cites workMicrobial translocation is a cause of systemic immune activation in chronic HIV infectionQ22251054
Codon usage limitation in the expression of HIV-1 envelope glycoproteinQ24498729
In vitro and in vivo characterization of anthrax anti-protective antigen and anti-lethal factor monoclonal antibodies after passive transfer in a mouse lethal toxin challenge model to define correlates of immunityQ28383065
Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodiesQ29614531
Rapid evolution of the neutralizing antibody response to HIV type 1 infectionQ29618603
Molecular diversity of Epstein-Barr virus IgG and IgA antibody responses in nasopharyngeal carcinoma: a comparison of Indonesian, Chinese, and European subjectsQ31078772
HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4(+) cell infection: an IgA gene and functional analysisQ33479955
Diversity considerations in HIV-1 vaccine selectionQ34136023
Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunizationQ34357220
Immunoglobulin G antibodies in human vaginal secretions after parenteral vaccinationQ34537706
Ancestral and consensus envelope immunogens for HIV-1 subtype C.Q34539222
Molecular mechanism of class switch recombination: linkage with somatic hypermutationQ34542246
Humoral immune responses to microbial infections in the genital tractQ34669747
Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremiaQ34848486
Methodological lessons from a cohort study of high risk women in TanzaniaQ35577076
Development and characterization of a novel single-cycle recombinant-virus assay to determine human immunodeficiency virus type 1 coreceptor tropismQ35635933
Immunoglobulin A antibodies against internal HIV-1 proteins neutralize HIV-1 replication inside epithelial cellsQ35636425
Long-lasting CCR5 internalization by antibodies in a subset of long-term nonprogressors: a possible protective effect against disease progressionQ35849745
Antigenicity and immunogenicity of HIV-1 consensus subtype B envelope glycoproteinsQ35933555
Cervicovaginal levels of lactoferrin, secretory leukocyte protease inhibitor, and RANTES and the effects of coexisting vaginoses in human immunodeficiency virus (HIV)-seronegative women with a high risk of heterosexual acquisition of HIV infectionQ36095139
Immunologic uniqueness of the genital tract: challenge for vaccine developmentQ36099546
Mucosal immune responses in the genital tract of HIV-1-exposed uninfected womenQ36863855
Neutralizing antibodies in mucosal secretions: IgG or IgA?Q37017811
GP41-specific antibody blocks cell-free HIV type 1 transcytosis through human rectal mucosa and model colonic epithelium.Q37063527
Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposureQ37344616
HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduitsQ37444317
Decline in sexually transmitted infection prevalence and HIV incidence in female barworkers attending prevention and care services in Mbeya Region, TanzaniaQ37862938
Immune activation in africa is environmentally-driven and is associated with upregulation of CCR5. Italian-Ugandan AIDS Project.Q38885690
Neutralizing monoclonal antibodies to human immunodeficiency virus type 1 do not inhibit viral transcytosis through mucosal epithelial cellsQ38945636
Evaluating neutralizing antibodies against HIV, SIV, and SHIV in luciferase reporter gene assaysQ39988991
Intraepithelial cell neutralization of HIV-1 replication by IgA.Q40437934
Cervicovaginal secretory antibodies to human immunodeficiency virus type 1 (HIV-1) that block viral transcytosis through tight epithelial barriers in highly exposed HIV-1-seronegative African women.Q40762424
Neutralization of human immunodeficiency virus type 1 (HIV-1) mediated by parotid IgA of HIV-1-infected patientsQ40878140
Lack of simian immunodeficiency virus (SIV) specific IgA response in the intestine of SIV infected rhesus macaquesQ41814443
HIV-1-specific mucosal IgA in a cohort of HIV-1-resistant Kenyan sex workersQ43976669
Absence of specific mucosal antibody responses in HIV-exposed uninfected sex workers from the GambiaQ44486781
Comparison of the distribution of IgG and IgA antibodies in serum and various mucosal fluids of HIV type 1-infected subjectsQ44499821
A comparison of HIV-1 antibody classes, titers, and specificities in paired semen and blood samples from HIV-1 seropositive menQ44545899
High-level ability of secretory IgA to block HIV type 1 transcytosis: contrasting secretory IgA and IgG responses to glycoprotein 160.Q44620120
Detection of specific IgA antibodies to varicella zoster virus in serum of patients with Ramsay Hunt syndromeQ44980411
HIV-specific IgG in cervicovaginal secretions of exposed HIV-uninfected female sexual partners of HIV-infected men.Q45027371
Enhanced chemiluminescence as a means of increasing the sensitivity of western blot assays for HIV antibodyQ45056651
Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120.Q45729198
Human immunodeficiency virus (HIV)-specific antibody in cervicovaginal lavage specimens obtained from women infected with HIV type 1.Q45731387
Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infectionQ45744790
Human immunodeficiency virus (HIV)-specific IgA and HIV neutralizing activity in the serum of exposed seronegative partners of HIV-seropositive personsQ45747957
Epidemiologic and biologic characterization of a cohort of human immunodeficiency virus type 1 highly exposed, persistently seronegative female sex workers in northern Thailand. Chiang Mai HEPS Working GroupQ45752474
Mucosal immune responses in four distinct compartments of women infected with human immunodeficiency virus type 1: a comparison by site and correlation with clinical informationQ45762213
Human immune responses to influenza virus vaccines administered by systemic or mucosal routesQ45772716
Cervicovaginal overproduction of specific IgG to human immunodeficiency virus (HIV) contrasts with normal or impaired IgA local response in HIV infectionQ45787391
Immunoglobulin A antibody against hepatitis B core antigen in the acute and persistent infection with hepatitis B virusQ45838118
Mucosal IgA in exposed, uninfected subjects: evidence for a role in protection against HIV infectionQ46180015
Predominate HIV1-specific IgG activity in various mucosal compartments of HIV1-infected individualsQ46471105
Cervical HIV-specific IgA in a population of commercial sex workers correlates with repeated exposure but not resistance to HIV.Q46807113
Codon usage optimization of HIV type 1 subtype C gag, pol, env, and nef genes: in vitro expression and immune responses in DNA-vaccinated miceQ47415954
HIV-1 neutralizing activity is correlated with increased levels of chemokines in saliva of HIV-1-exposed uninfected individuals.Q51714201
Human male genital tract secretions: both mucosal and systemic immune compartments contribute to the humoral immunity.Q51841750
Limited secretory-IgA response in cervicovaginal secretions from HIV-1 infected, but not high risk seronegative women: lack of correlation to genital viral shedding.Q52025108
Nonclassical mucosal antibodies predominate in genital secretions of HIV-1 infected chimpanzees.Q52846271
The ‘immunologic advantage’ of HIV-exposed seronegative individualsQ57997441
Mucosal and systemic HIV-1-specific immunity in HIV-1-exposed but uninfected heterosexual menQ57997551
Cross-Clade HIV-1–Specific Neutralizing IgA in Mucosal and Systemic Compartments of HIV-1–Exposed, Persistently Seronegative SubjectsQ57997566
Functional HIV-1 specific IgA antibodies in HIV-1 exposed, persistently IgG seronegative female sex workersQ57997576
HIV neutralizing IgA in exposed seronegative subjects recognise an epitope within the gp41 coiled-coil pocketQ57997632
HIV-specific mucosal and cellular immunity in HIV-seronegative partners of HIV-seropositive individualsQ57997711
Detection of Mucosal Antibodies in HIV Type 1-Infected IndividualsQ58168585
[3] Immunoglobulin A (IgA)Q58234753
HIV-Specific Antibodies But Not T-Cell Responses Are Associated With Protection in Seronegative Partners of HIV-1-Infected Individuals in CambodiaQ59661551
Intracellular Neutralization of HIV Transcytosis across Tight Epithelial Barriers by Anti-HIV Envelope Protein dIgA or IgMQ59705753
Quantitation of HIV-1-Specific IgG, IgA, and IgM Antibodies in Human Genital Tract SecretionsQ60686915
Degradation of immunoglobulins by secretions of human reproductive tractsQ67297246
Immunoglobulins A, G, and M to Cytomegalovirus during Recurrent Infection in Recipients of Allogeneic Bone Marrow TransplantationQ67913282
Decreased cervicovaginal production of both IgA1 and IgA2 subclasses in women with AIDSQ71917461
Detection of rectal antibodies to HIV-1 by a sensitive chemiluminescent western blot immunodetection methodQ72304746
Serum IgA-mediated neutralization of HIV type 1Q72363613
Mucosal immune response to trivalent live attenuated intranasal influenza vaccine in childrenQ73028942
Variations in immunoglobulins and IgA subclasses of human uterine cervical secretions around the time of ovulationQ73215687
False positivity of enzyme-linked immunosorbent assay for measurement of secretory IgA antibodies directed at HIV type 1 antigensQ73703199
Development and standardization of methods to evaluate the antibody response to an HIV-1 candidate vaccine in secretions and sera of seronegative vaccine recipientsQ74449425
In vitro comparison of the biologic activities of monoclonal monomeric IgA, polymeric IgA, and secretory IgAQ74506178
Paucity of antigen-specific IgA responses in sera and external secretions of HIV-type 1-infected individualsQ81109508
Immune responses that correlate with HIV-1 protection?Q81612295
Oral HIV-exposure elicits mucosal HIV-neutralizing antibodies in uninfected men who have sex with menQ83124960
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectvirologyQ7215
immunologyQ101929
infectious diseaseQ18123741
P304page(s)469-486
P577publication date2010-11-22
P1433published inAIDS Research and Human RetrovirusesQ4651880
P1476titleScarcity or absence of humoral immune responses in the plasma and cervicovaginal lavage fluids of heavily HIV-1-exposed but persistently seronegative women
P478volume27

Reverse relations

cites work (P2860)
Q37833671A novel whole-bacterial enzyme linked-immunosorbant assay to quantify Chlamydia trachomatis specific antibodies reveals distinct differences between systemic and genital compartments
Q34737407Adaptive HIV-specific B cell-derived humoral immune defenses of the intestinal mucosa in children exposed to HIV via breast-feeding
Q36753653Broadly neutralizing antibody specificities detected in the genital tract of HIV-1 infected women
Q37237797Cervicovaginal HIV-1-neutralizing immunoglobulin A detected among HIV-1-exposed seronegative female partners in HIV-1-discordant couples
Q37180418Characterization of serum antibodies from women immunized with Gardasil: A study of HPV-18 infection of primary human keratinocytes
Q36547166Comparative Evaluation of HIV-1 Neutralization in External Secretions and Sera of HIV-1-Infected Women
Q36150291Default in plasma and intestinal IgA responses during acute infection by simian immunodeficiency virus.
Q33865785Differences in serum IgA responses to HIV-1 gp41 in elite controllers compared to viral suppressors on highly active antiretroviral therapy
Q34034659Differential glycosylation of envelope gp120 is associated with differential recognition of HIV-1 by virus-specific antibodies and cell infection
Q37854081Evidence for the innate immune response as a correlate of protection in human immunodeficiency virus (HIV)-1 highly exposed seronegative subjects (HESN).
Q36356350Good CoP, bad CoP? Interrogating the immune responses to primate lentiviral vaccines
Q34282935HIV acquisition is associated with increased antimicrobial peptides and reduced HIV neutralizing IgA in the foreskin prepuce of uncircumcised men.
Q33939974HIV-1 specific IgA detected in vaginal secretions of HIV uninfected women participating in a microbicide trial in Southern Africa are primarily directed toward gp120 and gp140 specificities
Q37347345HIV-1-Neutralizing IgA Detected in Genital Secretions of Highly HIV-1-Exposed Seronegative Women on Oral Preexposure Prophylaxis
Q35192641HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies
Q33624872Humoral immune responses to HIV in the mucosal secretions and sera of HIV-infected women
Q37316629Immunotherapies to prevent mother-to-child transmission of HIV
Q36487349Impact of IgA constant domain on HIV-1 neutralizing function of monoclonal antibody F425A1g8.
Q92883468Monoclonal Antibody 2C6 Targets a Cross-Clade Conformational Epitope in gp41 with Highly Active Antibody-Dependent Cell Cytotoxicity
Q33911540Mucosal correlates of protection in HIV-1-exposed sero-negative persons
Q64905315Natural Immunity to HIV is associated with Low BLyS/BAFF levels and low frequencies of innate marginal zone like CD1c+ B-cells in the genital tract.
Q34044915Phase I randomised clinical trial of an HIV-1(CN54), clade C, trimeric envelope vaccine candidate delivered vaginally
Q34598141Randomized Phase I: Safety, Immunogenicity and Mucosal Antiviral Activity in Young Healthy Women Vaccinated with HIV-1 Gp41 P1 Peptide on Virosomes
Q62487341Rare Detection of Antiviral Functions of Polyclonal IgA Isolated from Plasma and Breast Milk Compartments in Women Chronically Infected with HIV-1
Q34399515Short communication: Anti-HIV-1 envelope immunoglobulin Gs in blood and cervicovaginal samples of Beninese commercial sex workers

Search more.