Low doses of flagellin-L2 multimer vaccines protect against challenge with diverse papillomavirus genotypes

scientific article

Low doses of flagellin-L2 multimer vaccines protect against challenge with diverse papillomavirus genotypes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VACCINE.2014.04.032
P932PMC publication ID4332780
P698PubMed publication ID24780250

P50authorRichard B S RodenQ87305927
Kirill KalninQ95980530
P2093author name stringJohn T Schiller
Patricia M Day
Subhashini Jagu
Jeffrey Almond
Lihua Shen
Yanhua Yan
Harold Kleanthous
Victor Costa
Neil Christensen
Robert Sabharwal
Stephen F Anderson
Svetlana Stegalkina
Timothy Tibbitts
P2860cites workStructural basis of TLR5-flagellin recognition and signalingQ24628830
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008Q27860674
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5Q28185796
Concatenated multitype L2 fusion proteins as candidate prophylactic pan-human papillomavirus vaccinesQ28246307
Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young womenQ28251260
Immunogenicity and efficacy of flagellin-fused vaccine candidates targeting 2009 pandemic H1N1 influenza in miceQ28743887
Efficacious recombinant influenza vaccines produced by high yield bacterial expression: a solution to global pandemic and seasonal needs.Q30369510
Superior efficacy of a recombinant flagellin:H5N1 HA globular head vaccine is determined by the placement of the globular head within flagellin.Q30379493
Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendmentsQ34021545
The structure of the TLR5-flagellin complex: a new mode of pathogen detection, conserved receptor dimerization for signalingQ34262635
Cross-neutralization of cutaneous and mucosal Papillomavirus types with anti-sera to the amino terminus of L2.Q34417608
Optimization of multimeric human papillomavirus L2 vaccinesQ34576677
Preclinical model to test human papillomavirus virus (HPV) capsid vaccines in vivo using infectious HPV/cottontail rabbit papillomavirus chimeric papillomavirus particlesQ35185992
Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine.Q35277985
A murine genital-challenge model is a sensitive measure of protective antibodies against human papillomavirus infectionQ35599310
Sensitivity of in situ detection with biotinylated probes of human papilloma virus type 16 DNA in frozen tissue sections of squamous cell carcinomas of the cervix.Q35818781
A human papillomavirus (HPV) in vitro neutralization assay that recapitulates the in vitro process of infection provides a sensitive measure of HPV L2 infection-inhibiting antibodiesQ36086265
Protection of rabbits against challenge with rabbit papillomaviruses by immunization with the N terminus of human papillomavirus type 16 minor capsid antigen L2.Q36314993
A protective and broadly cross-neutralizing epitope of human papillomavirus L2.Q36315086
Protection against heterologous human papillomavirus challenge by a synthetic lipopeptide vaccine containing a broadly cross-neutralizing epitope of L2.Q36545925
On regulation of phagosome maturation and antigen presentationQ36598303
Phylogenetic considerations in designing a broadly protective multimeric L2 vaccineQ36827128
Expression and immunogenicity of a streptococcal M protein epitope inserted in Salmonella flagellinQ36965479
Flagellin-F1-V fusion protein is an effective plague vaccine in mice and two species of nonhuman primatesQ37051021
Role of heparan sulfate in attachment to and infection of the murine female genital tract by human papillomavirusQ37099713
Efficacy of the HPV-16/18 AS04-adjuvanted vaccine against low-risk HPV types (PATRICIA randomized trial): an unexpected observationQ37213042
Declining genital Warts in young women in england associated with HPV 16/18 vaccination: an ecological studyQ37213048
TLR-mediated stimulation of APC: Distinct cytokine responses of B cells and dendritic cells.Q37235039
Cross-protective efficacy of two human papillomavirus vaccines: a systematic review and meta-analysisQ38037763
The impact of quadrivalent human papillomavirus (HPV; types 6, 11, 16, and 18) L1 virus-like particle vaccine on infection and disease due to oncogenic nonvaccine HPV types in generally HPV-naive women aged 16-26 yearsQ38383523
Efficacy of a vaccine that links viral epitopes to flagellin in protecting aged mice from influenza viral infection.Q38678908
Safety and immunogenicity of a recombinant M2e-flagellin influenza vaccine (STF2.4xM2e) in healthy adultsQ39744811
A universal epitope-based influenza vaccine and its efficacy against H5N1.Q39988803
Generation of HPV pseudovirions using transfection and their use in neutralization assays.Q40340652
Activation of innate immunity, inflammation, and potentiation of DNA vaccination through mammalian expression of the TLR5 agonist flagellin.Q40376275
In situ localization of human papilloma virus type 16 DNA in a metastasis of an endocervical adenocarcinomaQ41826995
Durable antibody responses following one dose of the bivalent human papillomavirus L1 virus-like particle vaccine in the Costa Rica Vaccine TrialQ42257816
Sustained efficacy and immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine: analysis of a randomised placebo-controlled trial up to 6.4 yearsQ43452461
Intranasal administration of a flagellin-adjuvanted inactivated influenza vaccine enhances mucosal immune responses to protect mice against lethal infectionQ45107740
Regulation of phagosome maturation by signals from toll-like receptorsQ47604798
Immune response to cholera toxin epitope inserted in Salmonella flagellinQ50195562
Human papillomavirus (HPV) vaccines: limited cross-protection against additional HPV types.Q51805351
Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos.Q52956682
Induction of a potent immune response in the elderly using the TLR-5 agonist, flagellin, with a recombinant hemagglutinin influenza-flagellin fusion vaccine (VAX125, STF2.HA1 SI).Q54361083
Chemotherapy for bladder cancerQ79347014
Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellinQ80155644
The value of HPV vaccinationQ83194126
P433issue28
P407language of work or nameEnglishQ1860
P1104number of pages8
P304page(s)3540-3547
P577publication date2014-04-26
P1433published inVaccineQ7907941
P1476titleLow doses of flagellin-L2 multimer vaccines protect against challenge with diverse papillomavirus genotypes
P478volume32

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cites work (P2860)
Q55215825A Dual-Type L2 11-88 Peptide from HPV Types 16/18 Formulated in Montanide ISA 720 Induced Strong and Balanced Th1/Th2 Immune Responses, Associated with High Titers of Broad Spectrum Cross-Reactive Antibodies in Vaccinated Mice.
Q92858730A rationally designed flagellin-L2 fusion protein induced serum and mucosal neutralizing antibodies against multiple HPV types
Q60909641Application of built-in adjuvants for epitope-based vaccines
Q36240497Chimeric L2-Based Virus-Like Particle (VLP) Vaccines Targeting Cutaneous Human Papillomaviruses (HPV)
Q55054189Cutaneous Papillomaviruses and Non-melanoma Skin Cancer: Causal Agents or Innocent Bystanders?
Q52729536DNA Vaccine-Encoded Flagellin Can Be Used as an Adjuvant Scaffold to Augment HIV-1 gp41 Membrane Proximal External Region Immunogenicity.
Q39021001Developments in L2-based human papillomavirus (HPV) vaccines
Q52312756Displaying 31RG-1 peptide on the surface of HPV16 L1 by use of a human papillomavirus chimeric virus-like particle induces cross-neutralizing antibody responses in mice.
Q28603888Durable immunity to oncogenic human papillomaviruses elicited by adjuvanted recombinant Adeno-associated virus-like particle immunogen displaying L2 17-36 epitopes
Q61817646Exploring the Papillomaviral Proteome to Identify Potential Candidates for a Chimeric Vaccine against Cervix Papilloma Using Immunomics and Computational Structural Vaccinology
Q41926367Human papillomavirus 16L1-58L2 chimeric virus-like particles elicit durable neutralizing antibody responses against a broad-spectrum of human papillomavirus types
Q35532771Identification of Broad-Genotype HPV L2 Neutralization Site for Pan-HPV Vaccine Development by a Cross-Neutralizing Antibody
Q38640038Incorporation of RG1 epitope concatemers into a self-adjuvanting Flagellin-L2 vaccine broaden durable protection against cutaneous challenge with diverse human papillomavirus genotypes
Q40490973Lipidated L2 epitope repeats fused with a single-chain antibody fragment targeting human FcγRI elicited cross-neutralizing antibodies against a broad spectrum of human papillomavirus types
Q38460209Next generation prophylactic human papillomavirus vaccines
Q35744303Preclinical refinements of a broadly protective VLP-based HPV vaccine targeting the minor capsid protein, L2
Q37014047Progress and prospects for L2-based human papillomavirus vaccines
Q39036718Recent advances in preclinical model systems for papillomaviruses
Q58375482Using vaccine Immunostimulation/Immunodynamic modelling methods to inform vaccine dose decision-making

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