Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis

scientific article

Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/CIRCULATIONAHA.114.010186
P932PMC publication ID4334727
P698PubMed publication ID25520375

P50authorLutz TautzQ56501559
Maud VandereykenQ57005835
Yotis A SenisQ60484604
Johan W.M. HeemskerkQ68596002
Tomas MustelinQ85072882
Cécile OuryQ87613384
P2093author name stringSouad Rahmouni
Hongbin Yuan
Marc Thiry
Eduard Sergienko
Patrizio Lancellotti
Thomas D Y Chung
William Guilmain
Johan W M Heemskerk
Ekaterina V Bobkova
Michel Moutschen
Pierre Drion
Johannes A Eble
Emilie Théâtre
Russell Dahl
Christelle Lecut
Alexandre Hego
Lucia Musumeci
Catia V Diogo
Justin Rascon
Karen Gilio
Lisbeth Maurissen
Marijke J Kuijpers
Yalda Mostofi
P2860cites workThe mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancerQ24314853
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescenceQ24316042
Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHRQ24316477
Expression cloning of a human dual-specificity phosphataseQ24562377
Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivoQ24669536
Multidentate Small-Molecule Inhibitors of Vaccinia H1-Related (VHR) Phosphatase Decrease Proliferation of Cervix Cancer CellsQ27658054
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settingsQ27861111
Protein tyrosine phosphatases in the human genomeQ28265924
GPVI and integrin alphaIIb beta3 signaling in plateletsQ28267414
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagenQ28364081
The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosisQ28509969
Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activationQ30481898
Inhibition of the Hematopoietic Protein Tyrosine Phosphatase by Phenoxyacetic AcidsQ30499658
DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphataseQ30579145
Discovery of VHR phosphatase inhibitors with micromolar activity based on structure-based virtual screeningQ33317564
Roles of platelet STIM1 and Orai1 in glycoprotein VI- and thrombin-dependent procoagulant activity and thrombus formationQ34025335
P2X(1)-mediated activation of extracellular signal-regulated kinase 2 contributes to platelet secretion and aggregation induced by collagenQ34150092
Overexpression of the platelet P2X1 ion channel in transgenic mice generates a novel prothrombotic phenotypeQ34169675
Vaccinia H1-related phosphatase is a phosphatase of ErbB receptors and is down-regulated in non-small cell lung cancerQ34695575
Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome"Q35222996
A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivoQ36370457
Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor gamma chain complex on human plateletsQ36401453
Regulation of MAP kinases by the VHR dual-specific phosphatase: implications for cell growth and differentiationQ36609060
Antiplatelet therapies for the treatment of cardiovascular diseaseQ37684794
Protein tyrosine phosphatases: structure, function, and implication in human disease.Q38122079
Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signalingQ41976932
Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.Q42582678
Development of a Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structureQ42813512
Platelet adhesion enhances the glycoprotein VI-dependent procoagulant response: Involvement of p38 MAP kinase and calpainQ43576470
Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR, a dual-specificity ERK phosphatase: implications for the molecular mechanism of the inhibitionQ43832835
4-isoavenaciolide covalently binds and inhibits VHR, a dual-specificity phosphatase.Q44090503
Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function.Q46040273
Key role of platelet procoagulant activity in tissue factor-and collagen-dependent thrombus formation in arterioles and venules in vivo differential sensitivity to thrombin inhibitionQ46606513
GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolismQ46684669
Calcium signalling in platelets and other cellsQ47776811
Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice.Q51828070
The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletionQ52550457
Identification of a potent inhibitor of human dual-specific phosphatase, VHR, from computer-aided and NMR-based screening to cellular effects.Q53522193
Platelet Glycoprotein VI Dimerization, an Active Process Inducing Receptor Competence, Is an Indicator of Platelet ReactivityQ61866592
The physiological and pathophysiological roles of platelet CLEC-2Q63407979
The role of ITAM- and ITIM-coupled receptors in platelet activation by collagenQ63408039
Platelets activated by collagen through immunoreceptor tyrosine-based activation motif play pivotal role in initiation and generation of neointimal hyperplasia after vascular injuryQ77690015
CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosisQ84313347
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectthrombosisQ261327
P304page(s)656-668
P577publication date2014-12-17
P1433published inCirculationQ578091
P1476titleDual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis
P478volume131

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cites work (P2860)
Q90292249AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation
Q92652900Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis
Q41660620Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases.
Q35562905DUSP3 Genetic Deletion Confers M2-like Macrophage-Dependent Tolerance to Septic Shock
Q38651960Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration
Q40077080Dual-Specificity Phosphatase 3 Deletion Protects Female, but Not Male, Mice from Endotoxemia-Induced and Polymicrobial-Induced Septic Shock
Q92495301Dual-Specificity Phosphatases in Immunity and Infection: An Update
Q40579483Functional Analysis of Protein Tyrosine Phosphatases in Thrombosis and Hemostasis.
Q50892082Gq pathway regulates proximal C-type lectin-like receptor-2 (CLEC-2) signaling in platelets.
Q37386201Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release
Q35671956Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.
Q58699207Revisiting the roles of VHR/DUSP3 phosphatase in human diseases
Q38372232VHR/DUSP3 phosphatase: structure, function and regulation
Q46419191Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release

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