CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit⁺ cells in rats

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CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit⁺ cells in rats is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...989810F
P356DOI10.1371/JOURNAL.PONE.0089810
P932PMC publication ID3933653
P698PubMed publication ID24587052
P5875ResearchGate publication ID260448313

P50authorJennifer I DrakeQ84481804
P2093author name stringHarm J Bogaard
Carlyne D Cool
Norbert F Voelkel
Laszlo Farkas
Daniela Farkas
Donatas Kraskauskas
Vita Kraskauskiene
Aysar A Alhussaini
P2860cites workSignaling by Kit protein-tyrosine kinase--the stem cell factor receptorQ24318673
Molecular pathogenesis of pulmonary arterial hypertensionQ24634317
Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis.Q52118613
Lung microvascular endothelium is enriched with progenitor cells that exhibit vasculogenic capacity.Q53512178
C-kit-positive cells accumulate in remodeled vessels of idiopathic pulmonary arterial hypertension.Q54379158
Targeting of c-kit+ haematopoietic progenitor cells prevents hypoxic pulmonary hypertension.Q54646705
SDF-1α/CXCR4 Axis Is Instrumental in Neointimal Hyperplasia and Recruitment of Smooth Muscle Progenitor CellsQ56921714
Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertensionQ59261131
Circulating Fibrocytes Are an Indicator of Poor Prognosis in Idiopathic Pulmonary FibrosisQ61892487
Role of c-kit/Kit ligand signaling in regulating vasculogenesisQ79092300
VEGF-R blockade causes endothelial cell apoptosis, expansion of surviving CD34+ precursor cells and transdifferentiation to smooth muscle-like and neuronal-like cellsQ80474847
Vascular wall resident progenitor cells: a source for postnatal vasculogenesisQ82766257
Overexpression of CXCR4 in mesenchymal stem cells promotes migration, neuroprotection and angiogenesis in a rat model of strokeQ83332757
Stem cells and cell therapies in lung biology and lung diseasesQ84303950
Formation of plexiform lesions in experimental severe pulmonary arterial hypertensionQ84404717
Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in ratsQ28569530
CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activityQ28587353
Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironmentQ29346986
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1Q29615241
Updated clinical classification of pulmonary hypertension.Q30378433
Circulating peripheral blood fibrocytes in human fibrotic interstitial lung diseaseQ30442380
Inhibitory effect of CXC chemokine receptor 4 antagonist AMD3100 on bleomycin induced murine pulmonary fibrosisQ33942836
Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy.Q34228118
Generation of functional blood vessels from a single c-kit+ adult vascular endothelial stem cellQ34307717
Strategic plan for lung vascular research: An NHLBI-ORDR Workshop ReportQ34535086
Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamideQ34829342
Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure.Q35010981
Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineageQ35087969
Evidence for human lung stem cellsQ35399248
Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertensionQ35833414
Pulmonary vascular disease in mice xenografted with human BM progenitors from patients with pulmonary arterial hypertensionQ36163044
Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension.Q36769644
Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosisQ36849123
Emerging functions of c-kit and its ligand stem cell factor in dendritic cells: regulators of T cell differentiationQ36959863
Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodentsQ37111334
VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in ratsQ37170742
The definition of EPCs and other bone marrow cells contributing to neoangiogenesis and tumor growth: is there common ground for understanding the roles of numerous marrow-derived cells in the neoangiogenic process?Q37374031
Reversible or irreversible remodeling in pulmonary arterial hypertensionQ37653353
Strategies for homeostatic stem cell self-renewal in adult tissuesQ37887870
A review on CXCR4/CXCL12 axis in oncology: no place to hide.Q38017493
Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cellsQ40421753
New models of pulmonary hypertension based on VEGF receptor blockade-induced endothelial cell apoptosisQ41853468
Evidence of dysfunction of endothelial progenitors in pulmonary arterial hypertensionQ42641623
The cancer paradigm of severe pulmonary arterial hypertensionQ42682888
Treprostinil inhibits the recruitment of bone marrow-derived circulating fibrocytes in chronic hypoxic pulmonary hypertension.Q43043847
Antifibrotic effects of CXCR4 antagonist in bleomycin-induced pulmonary fibrosis in miceQ44018101
Thyroid hormone is highly permissive in angioproliferative pulmonary hypertension in rats.Q44977498
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectpulmonary hypertensionQ1128595
P304page(s)e89810
P577publication date2014-02-24
P1433published inPLOS OneQ564954
P1476titleCXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit⁺ cells in rats
P478volume9

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cites work (P2860)
Q60935302Blood Outgrowth and Proliferation of Endothelial Colony Forming Cells are Related to Markers of Disease Severity in Patients with Pulmonary Arterial Hypertension
Q92932841Clonally selected primitive endothelial cells promote occlusive pulmonary arteriopathy and severe pulmonary hypertension in rats exposed to chronic hypoxia
Q90822809Effects of masitinib compared with tadalafil for the treatment of monocrotaline-induced pulmonary arterial hypertension in rats
Q90714004Effects of toceranib compared with sorafenib on monocrotaline-induced pulmonary arterial hypertension and cardiopulmonary remodeling in rats
Q52583184Endothelial and Smooth Muscle Cell Interaction via FoxM1 Signaling Mediates Vascular Remodeling and Pulmonary Hypertension.
Q64082260Endothelial cells are a source of Nestin expression in Pulmonary Arterial Hypertension
Q97548235HIV X4 Variants Increase Arachidonate 5-Lipoxygenase in the Pulmonary Microenvironment and are associated with Pulmonary Arterial Hypertension
Q54964312High expression of CXCR4 and stem cell markers in a monocrotaline and chronic hypoxia-induced rat model of pulmonary arterial hypertension.
Q48042730Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle.
Q64244878Involvement of CXCR4 in Normal and Abnormal Development
Q34305561Nuclear factor κB inhibition reduces lung vascular lumen obliteration in severe pulmonary hypertension in rats.
Q92924608Pulmonary Hypertension Remodels the Genomic Fabrics of Major Functional Pathways
Q38709505Reconciling paradigms of abnormal pulmonary blood flow and quasi-malignant cellular alterations in pulmonary arterial hypertension
Q37747432Sildenafil attenuates hypoxic pulmonary remodelling by inhibiting bone marrow progenitor cells
Q64090954Silibinin efficacy in a rat model of pulmonary arterial hypertension using monocrotaline and chronic hypoxia
Q36797479Simvastatin improves the homing of BMSCs via the PI3K/AKT/miR-9 pathway
Q45046014The Roles of Immunity in the Prevention and Evolution of Pulmonary Arterial Hypertension

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