| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2014PLoSO...990685C |
| P356 | DOI | 10.1371/JOURNAL.PONE.0090685 |
| P932 | PMC publication ID | 3940939 |
| P698 | PubMed publication ID | 24594974 |
| P5875 | ResearchGate publication ID | 260526922 |
| P2093 | author name string | Christopher Mayer | |
| Alexander Rosendahl | |||
| Helena Cucak | |||
| Lars Groth Grunnet | |||
| Lise Høj Thomsen | |||
| Morten Tonnesen | |||
| P2860 | cites work | Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance | Q56742768 |
| Laboratory animals exhibiting obesity and diabetes syndromes | Q67542769 | ||
| Cytokines cause functional and structural damage to isolated islets of Langerhans | Q69912058 | ||
| Hormone regulation of glucose metabolism in the genetically obese-diabetic mouse (db/db): glucose metabolism in the perfused hindquarters of lean and obese mice | Q71538064 | ||
| Human blood-derived macrophages induce apoptosis in human plaque-derived vascular smooth muscle cells by Fas-ligand/Fas interactions | Q74514968 | ||
| Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation | Q83782039 | ||
| Inflammation, stress, and diabetes | Q24523336 | ||
| Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance | Q24617743 | ||
| Inflammation and metabolic disorders | Q27860923 | ||
| Obesity is associated with macrophage accumulation in adipose tissue | Q27860976 | ||
| Pancreatic β-cell death in response to pro-inflammatory cytokines is distinct from genuine apoptosis | Q28476371 | ||
| Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components | Q28511151 | ||
| Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle | Q28586493 | ||
| IKK-beta links inflammation to obesity-induced insulin resistance | Q29614285 | ||
| Global and societal implications of the diabetes epidemic | Q29614551 | ||
| Toll-like receptors and innate immunity | Q29615458 | ||
| TLR4 links innate immunity and fatty acid-induced insulin resistance | Q29617577 | ||
| Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis. | Q33605173 | ||
| Toll-like receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis | Q33830986 | ||
| Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling | Q34257301 | ||
| Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets | Q34796756 | ||
| Five stages of evolving beta-cell dysfunction during progression to diabetes | Q35961960 | ||
| Mechanisms of beta-cell death in type 2 diabetes. | Q36321520 | ||
| Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities | Q36321572 | ||
| TNF-α mediates macrophage-induced bystander effects through Netrin-1. | Q36323041 | ||
| Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages. | Q36339484 | ||
| Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects | Q36906306 | ||
| Human polymorphonuclear neutrophil responses to Burkholderia pseudomallei in healthy and diabetic subjects | Q37033064 | ||
| Cytokine production by islets in health and diabetes: cellular origin, regulation and function. | Q37680187 | ||
| The worldwide epidemiology of type 2 diabetes mellitus--present and future perspectives | Q37953791 | ||
| A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways | Q38297619 | ||
| Impairment of host resistance to Listeria monocytogenes infection in liver of db/db and ob/ob mice | Q38332769 | ||
| Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I. | Q39788894 | ||
| Toll-like receptor 4 suppression leads to islet allograft survival | Q40137830 | ||
| Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study | Q40603438 | ||
| Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling | Q41006478 | ||
| Diabetes-obesity syndromes in mice | Q41463282 | ||
| Defects in innate immunity predispose C57BL/6J-Leprdb/Leprdb mice to infection by Staphylococcus aureus | Q41971442 | ||
| Vascular endothelial growth factor-mediated islet hypervascularization and inflammation contribute to progressive reduction of β-cell mass. | Q42409734 | ||
| Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes | Q42833865 | ||
| Altered cytokine and nitric oxide secretion in vitro by macrophages from diabetic type II-like db/db mice | Q43470650 | ||
| Evidence of expression of endotoxin receptors CD14, toll-like receptors TLR4 and TLR2 and associated molecule MD-2 and of sensitivity to endotoxin (LPS) in islet beta cells | Q44517194 | ||
| Accumulation of M1-like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization | Q45304466 | ||
| Increased expression of toll-like receptor 4 and inflammatory cytokines, interleukin-6 in particular, in islets from a mouse model of obesity and type 2 diabetes | Q45807229 | ||
| Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle | Q46865480 | ||
| Soluble macrophage factors trigger apoptosis in cultured hippocampal neurons | Q48631418 | ||
| A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of beta-cell dysfunction in the obese diabetic db/db mouse. | Q51034398 | ||
| Increased number of islet-associated macrophages in type 2 diabetes. | Q53545508 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | toll-like receptor | Q408004 |
| type 2 diabetes | Q3025883 | ||
| P304 | page(s) | e90685 | |
| P577 | publication date | 2014-03-03 | |
| P1433 | published in | PLOS One | Q564954 |
| P1476 | title | Macrophage contact dependent and independent TLR4 mechanisms induce β-cell dysfunction and apoptosis in a mouse model of type 2 diabetes | |
| P478 | volume | 9 |
| Q49394960 | Ageing potentiates diet-induced glucose intolerance, β-cell failure and tissue inflammation through TLR4. |
| Q93205455 | Contribution of Oxidative Stress and Impaired Biogenesis of Pancreatic β-Cells to Type 2 Diabetes |
| Q26749276 | Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation |
| Q34120699 | Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes |
| Q36815448 | Impaired coronary microcirculation in type 2 diabetic patients is associated with elevated circulating regulatory T cells and reduced number of IL-21R⁺ T cells |
| Q46224816 | Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in db/db mice |
| Q28083768 | Minireview: Emerging Concepts in Islet Macrophage Biology in Type 2 Diabetes |
| Q41680364 | Mitochondrial toxicity of triclosan on mammalian cells. |
| Q35688327 | Neutralizing Anti-IL20 Antibody Treatment Significantly Modulates Low Grade Inflammation without Affecting HbA1c in Type 2 Diabetic db/db Mice |
| Q34257123 | Reduction of specific circulating lymphocyte populations with metabolic risk factors in patients at risk to develop type 2 diabetes |
| Q90736570 | Sustained maternal inflammation during the early third-trimester yields intrauterine growth restriction, impaired skeletal muscle glucose metabolism, and diminished β-cell function in fetal sheep1,2 |
| Q92622032 | TAK-875 Mitigates β-Cell Lipotoxicity-Induced Metaflammation Damage through Inhibiting the TLR4-NF-κB Pathway |
| Q28276657 | The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease |
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