Identification of therapeutic covariant microRNA clusters in hypoxia-treated cardiac progenitor cell exosomes using systems biology

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Identification of therapeutic covariant microRNA clusters in hypoxia-treated cardiac progenitor cell exosomes using systems biology is …
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scholarly articleQ13442814

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P356DOI10.1161/CIRCRESAHA.116.304360
P932PMC publication ID4338016
P698PubMed publication ID25344555

P50authorKristin M FrenchQ47502355
P2093author name stringMichael E Davis
Milton E Brown
Joshua T Maxwell
Charles D Searles
Warren D Gray
Manu O Platt
Shohini Ghosh-Choudhary
P2860cites workA micro RNA processing defect in rapidly progressing idiopathic pulmonary fibrosisQ21135329
Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell lineQ21136096
Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic studyQ24294853
Metabolic adaptation to a disruption in oxygen supply during myocardial ischemia and reperfusion is underpinned by temporal and quantitative changes in the cardiac proteomeQ39392907
Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in miceQ39508688
Exosomes as critical agents of cardiac regeneration triggered by cell therapy.Q40477633
Cardiomyocyte progenitor cell-derived exosomes stimulate migration of endothelial cellsQ41836901
Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR).Q41875540
Emerging roles of exosomes in neuron-glia communicationQ42139956
Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cellsQ42374637
Induced release of membrane vesicles from rat adipocytes containing glycosylphosphatidylinositol-anchored microdomain and lipid droplet signalling proteinsQ46245778
Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction.Q50613492
Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells.Q51345347
Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cellsQ24300024
Exosomes from human CD34(+) stem cells mediate their proangiogenic paracrine activityQ24321699
Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomesQ24604279
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkersQ24614672
MicroRNA-210 as a novel therapy for treatment of ischemic heart diseaseQ24633429
miRiad roles for the miR-17-92 cluster in development and diseaseQ24646970
Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animalsQ24648246
The microRNA.org resource: targets and expressionQ24650094
MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20Q24651483
Circulating microRNAs: biomarkers or mediators of cardiovascular diseases?Q26992023
Role of microRNAs in the reperfused myocardium towards post-infarct remodellingQ27000076
Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)Q28216990
De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid culturesQ28277249
CCN2 is required for bleomycin‐induced skin fibrosis in miceQ28295283
Heart disease and stroke statistics--2014 update: a report from the American Heart AssociationQ29547691
Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasmaQ29547772
MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteinsQ29615034
TGF-beta signaling and the fibrotic responseQ29620099
Adult cardiac stem cells are multipotent and support myocardial regenerationQ29620122
Paracrine mechanisms in adult stem cell signaling and therapyQ29620571
Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac functionQ33863225
Small molecule inhibition of RISC loadingQ34057371
Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damageQ34189929
Cardiac plasticityQ34764732
MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic ratsQ34873256
Extracellular/circulating microRNAs and their potential role in cardiovascular disease.Q35513779
Ultrastructural evidence of exosome secretion by progenitor cells in adult mouse myocardium and adult human cardiospheresQ36438947
Patient specific proteolytic activity of monocyte-derived macrophages and osteoclasts predicted with temporal kinase activation states during differentiation.Q36453271
MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemiaQ36739746
Cell-specific effects of miR-221/222 in vessels: molecular mechanism and therapeutic applicationQ36877313
Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injury.Q37066520
Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expressionQ37372976
Intercellular communication: diverse structures for exchange of genetic informationQ38003288
Exosomes and cardiac repair after myocardial infarctionQ38179329
P433issue2
P921main subjecthypoxiaQ105688
microRNAQ310899
systems biologyQ815297
P304page(s)255-263
P577publication date2014-10-24
P1433published inCirculation ResearchQ2599020
P1476titleIdentification of therapeutic covariant microRNA clusters in hypoxia-treated cardiac progenitor cell exosomes using systems biology
P478volume116

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