Increased expression of 5-HT₆ receptors in dorsolateral striatum decreases habitual lever pressing, but does not affect learning acquisition of simple operant tasks in rats

scientific article

Increased expression of 5-HT₆ receptors in dorsolateral striatum decreases habitual lever pressing, but does not affect learning acquisition of simple operant tasks in rats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1460-9568.2011.07756.X
P932PMC publication ID3138869
P698PubMed publication ID21714816
P5875ResearchGate publication ID51453407

P2093author name stringDaniel Eskenazi
John F Neumaier
P2860cites workSelective serotonin re-uptake inhibitors (SSRIs) versus placebo for obsessive compulsive disorder (OCD)Q24242402
Probing compulsive and impulsive behaviors, from animal models to endophenotypes: a narrative reviewQ24602117
Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the ratQ24651957
'Compulsive' lever-pressing in rats is attenuated by the serotonin re-uptake inhibitors paroxetine and fluvoxamine but not by the tricyclic antidepressant desipramine or the anxiolytic diazepamQ44929522
Low-serotonin levels increase delayed reward discounting in humans.Q46042455
The role of the dorsomedial striatum in instrumental conditioningQ46306217
Blockade of NMDA receptors in the dorsomedial striatum prevents action-outcome learning in instrumental conditioningQ46342377
The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat.Q46547641
Inactivation of dorsolateral striatum enhances sensitivity to changes in the action-outcome contingency in instrumental conditioning.Q46695444
BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism.Q46812475
Increased expression of 5-HT6 receptors in the nucleus accumbens blocks the rewarding but not psychomotor activating properties of cocaineQ48104404
Endogenous serotonin excites striatal cholinergic interneurons via the activation of 5-HT 2C, 5-HT6, and 5-HT7 serotonin receptors: implications for extrapyramidal side effects of serotonin reuptake inhibitors.Q48319536
Uncertainty-based competition between prefrontal and dorsolateral striatal systems for behavioral controlQ48696267
Activation of dorsal raphe serotonin neurons underlies waiting for delayed rewards.Q51609775
Colocalization of serotonin receptor subtypes 5-HT2A, 5-HT2C, and 5-HT6 with neuropeptides in rat striatumQ71517304
Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466Q28236198
Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cellsQ28243874
5-ht6 receptorsQ28245286
Increased expression of 5-HT6 receptors in the rat dorsomedial striatum impairs instrumental learningQ28566415
5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaineQ28572379
Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugsQ28580751
Neural systems of reinforcement for drug addiction: from actions to habits to compulsionQ29547251
D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neuronsQ29615480
The role of the basal ganglia in habit formationQ29619829
5-HT6 receptor antagonist reversal of emotional learning and prepulse inhibition deficits induced by apomorphine or scopolamine.Q30491992
The distribution of 5-HT(6) receptors in rat brain: an autoradiographic binding study using the radiolabelled 5-HT(6) receptor antagonist [(125)I]SB-258585.Q34122424
Learning and memory functions of the Basal GangliaQ34132332
Differential reinforcement of other behavior (DRO): a yoked-control comparisonQ34268502
The 5-HT6 Receptor Antagonist SB-271046 Reverses Scopolamine-Disrupted Consolidation of a Passive Avoidance Task and Ameliorates Spatial Task Deficits in Aged RatsQ34271590
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptorsQ34322179
Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitizationQ34679428
Schedule-induced polydipsia: a rat model of obsessive-compulsive disorderQ34772626
Metalearning and neuromodulation.Q34951507
Opponent interactions between serotonin and dopamineQ34951616
5-HT6 receptors: a novel target for cognitive enhancementQ36187762
Behavioral and neural mechanisms of compulsive drug seekingQ36323765
Functions of frontostriatal systems in cognition: comparative neuropsychopharmacological studies in rats, monkeys and humansQ36424868
Pharmacotherapy of obsessive-compulsive disorder and obsessive-compulsive spectrum disordersQ36464825
Increased expression of the 5-HT6 receptor by viral mediated gene transfer into posterior but not anterior dorsomedial striatum interferes with acquisition of a discrete action–outcome taskQ36490844
Dopaminergic mechanisms in actions and habitsQ36899781
Serotoninergic mechanisms in the treatment of obsessive-compulsive disorderQ37135911
Habits, rituals, and the evaluative brainQ37193050
Serotonin modulation of the basal ganglia circuitry: therapeutic implication for Parkinson's disease and other motor disordersQ37260943
Frontal-striatal abnormalities underlying behaviours in the compulsive-impulsive spectrumQ37591618
Serotonin and dopamine: unifying affective, activational, and decision functionsQ37782264
Opponency revisited: competition and cooperation between dopamine and serotoninQ37794770
Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modelingQ40611704
Activation of the central serotonergic system in response to delayed but not omitted rewardsQ42611598
5-HT6 antagonism attenuates cue-induced relapse to cocaine seeking without affecting cocaine reinforcementQ43082148
Activation of 5-HT(6) receptors facilitates attentional set shiftingQ43245177
Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaine.Q44251948
Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learningQ44747862
Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behaviorQ44822531
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectstriatumQ1319792
P304page(s)343-351
P577publication date2011-06-30
P1433published inEuropean Journal of NeuroscienceQ5412733
P1476titleIncreased expression of 5-HT₆ receptors in dorsolateral striatum decreases habitual lever pressing, but does not affect learning acquisition of simple operant tasks in rats
P478volume34

Reverse relations

cites work (P2860)
Q35688656Deconstructing 5-HT6 receptor effects on striatal circuit function
Q37378161Differential effect of viral overexpression of nucleus accumbens shell 5-HT1B receptors on stress- and cocaine priming-induced reinstatement of cocaine seeking
Q85789509Gene therapy for psychiatric disorders
Q48597859Prefronto-subcortical imbalance characterizes poor decision-making: neurochemical and neural functional evidences in rats.
Q48068395Serotonin Transporter Genetic Variation is Differentially Associated with Reflexive- and Reflective-Optimal Learning
Q40824207Striatal 5-HT6 Receptors Regulate Cocaine Reinforcement in a Pathway-Selective Manner.
Q90009173The neurochemical substrates of habitual and goal-directed control
Q38897357Translatable and Back-Translatable Measurement of Impulsivity and Compulsivity: Convergent and Divergent Processes
Q36287885Tryptophan Depletion Promotes Habitual over Goal-Directed Control of Appetitive Responding in Humans

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