In vitro assays elucidate peculiar kinetics of clindamycin action against Toxoplasma gondii

scientific article

In vitro assays elucidate peculiar kinetics of clindamycin action against Toxoplasma gondii is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/AAC.39.7.1530
P932PMC publication ID162776
P698PubMed publication ID7492099
P5875ResearchGate publication ID15707200

P50authorDavid S RoosQ56394669
P2093author name stringM K Bhopale
M E Fichera
P2860cites workChloroplast ribosomes and protein synthesisQ24634608
In vitro effects of four macrolides (roxithromycin, spiramycin, azithromycin [CP-62,993], and A-56268) on Toxoplasma gondiiQ28359823
Assessment of therapy for toxoplasma encephalitis. The TE Study GroupQ33454020
Comparison of mutants of Toxoplasma gondii selected for resistance to azithromycin, spiramycin, or clindamycinQ33746997
Localization of azithromycin in Toxoplasma gondii-infected cellsQ33755229
Antibiotic resistance mutations in the chloroplast 16S and 23S rRNA genes of Chlamydomonas reinhardtii: correlation of genetic and physical maps of the chloroplast genomeQ33955799
Inhibition of cytoplasmic and organellar protein synthesis in Toxoplasma gondii. Implications for the target of macrolide antibiotics.Q34196036
The parasitophorous vacuole membrane surrounding intracellular Toxoplasma gondii functions as a molecular sieveQ34980590
New micromethod to study the effect of antimicrobial agents on Toxoplasma gondii: comparison of sulfadoxine and sulfadiazine individually and in combination with pyrimethamine and study of clindamycin, metronidazole, and cyclosporin A.Q35639477
Toxoplasmic encephalitis in AIDS.Q35810946
Parasiticidal effect of clindamycin on Toxoplasma gondii grown in cultured cells and selection of a drug-resistant mutantQ35836436
Current recommendations and future prospects in the treatment of toxoplasmosisQ38756395
In vitro assessment of antimicrobial agents against Toxoplasma gondiiQ39050049
Evaluation of the efficacy and safety of clindamycin plus pyrimethamine for induction and maintenance therapy of toxoplasmic encephalitis in AIDS.Q39123475
Effect of clindamycin on intracellular replication, protein synthesis, and infectivity of Toxoplasma gondiiQ39883651
Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondiiQ40501292
Interaction of the antibiotics clindamycin and lincomycin with Escherichia coli 23S ribosomal RNA.Q40534214
Treatment of toxoplasmic encephalitis in patients with AIDS. A randomized trial comparing pyrimethamine plus clindamycin to pyrimethamine plus sulfadiazine. The California Collaborative Treatment GroupQ40738767
Interactions between Toxoplasma gondii and its mammalian host cellsQ40788924
Tandemly repeated genes encode nucleoside triphosphate hydrolase isoforms secreted into the parasitophorous vacuole of Toxoplasma gondii.Q42695544
Sulphadiazine desensitization in patients with AIDS and cerebral toxoplasmosisQ43889281
Have malaria parasites three genomes?Q47996291
Treatment of central nervous system toxoplasmosis with pyrimethamine/sulfadiazine combination in 35 patients with the acquired immunodeficiency syndrome. Efficacy of long-term continuous therapyQ48134771
Organisation and expression of small subunit ribosomal RNA genes encoded by a 35-kilobase circular DNA in Plasmodium falciparumQ48212630
Toxoplasma gondii: secretion of a potent nucleoside triphosphate hydrolase into the parasitophorous vacuoleQ72798338
Toxoplasmic encephalitis in patients with the acquired immunodeficiency syndrome. Members of the ACTG 077p/ANRS 009 Study TeamQ72914757
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectToxoplasma gondiiQ131003
clindamycinQ422273
P304page(s)1530-1537
P577publication date1995-07-01
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleIn vitro assays elucidate peculiar kinetics of clindamycin action against Toxoplasma gondii
P478volume39

Reverse relations

cites work (P2860)
Q35865145'FAS't inhibition of malaria
Q35142236A Toxoplasma gondii mutant highlights the importance of translational regulation in the apicoplast during animal infection
Q30044413A dual-targeted aminoacyl-tRNA synthetase in Plasmodium falciparum charges cytosolic and apicoplast tRNACys
Q47808765A genetic screen in rodent malaria parasites identifies five new apicoplast putative membrane transporters, one of which is essential in human malaria parasites.
Q47823727A plastid organelle as a drug target in apicomplexan parasites.
Q39673553A plastid segregation defect in the protozoan parasite Toxoplasma gondii
Q34722217A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum
Q43936787An rRNA mutation identifies the apicoplast as the target for clindamycin in Toxoplasma gondii
Q38811119Anti-Toxoplasma activity and impact evaluation of lyophilization, hot molding process, and gamma-irradiation techniques on CLH-PLGA intravitreal implants.
Q37726477Antibiotics for human toxoplasmosis: a systematic review of randomized trials
Q35840382Antimalarial combinations
Q39720138Antiplasmodial thiostrepton derivatives: proteasome inhibitors with a dual mode of action.
Q33702247Apicomplexan plastids as drug targets
Q36018552Apicoplast-targeting antibacterials inhibit the growth of Babesia parasites
Q36791777Apoptosis-like cell death pathways in the unicellular parasite Toxoplasma gondii following treatment with apoptosis inducers and chemotherapeutic agents: a proof-of-concept study
Q33687965Biochemical peculiarities and drug targets in Cryptosporidium parvum: lessons from other coccidian parasites
Q40611245Cerebral Toxoplasmosis
Q27973797Characterization of two malaria parasite organelle translation elongation factor G proteins: the likely targets of the anti-malarial fusidic acid
Q34904340Chemistry and biology of macrolide antiparasitic agents
Q28547065Ciprofloxacin Derivatives Affect Parasite Cell Division and Increase the Survival of Mice Infected with Toxoplasma gondii
Q38138018Clinical features and treatment of ocular toxoplasmosis
Q26782581Clinically Available Medicines Demonstrating Anti-Toxoplasma Activity
Q64091493Combination of Clindamycin and Azithromycin as Alternative Treatment for Toxoplasma gondii Encephalitis
Q43615024DNA replication and daughter cell budding are not tightly linked in the protozoan parasite Toxoplasma gondii
Q33953731Daughter cell assembly in the protozoan parasite Toxoplasma gondii
Q91989306Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking
Q90265315Discovery of Novel Anti-cryptosporidial Activities From Natural Products by in vitro High-Throughput Phenotypic Screening
Q42125453Disruption of the expression of a non-coding RNA significantly impairs cellular differentiation in Toxoplasma gondii
Q46330680Double-stranded RNA specific to adenosine kinase and hypoxanthine-xanthine-guanine-phosphoribosyltransferase retards growth of Toxoplasma gondii
Q30806899Dynamics of Toxoplasma gondii differentiation
Q34051207Dynamics of the Toxoplasma gondii inner membrane complex.
Q89972997Evaluating the GCN5b bromodomain as a novel therapeutic target against the parasite Toxoplasma gondii
Q24643897Extrachromosomal DNA in the Apicomplexa
Q40616078Fitness effects of DHFR-TS mutations associated with pyrimethamine resistance in apicomplexan parasites
Q36729982Garcinol Inhibits GCN5-Mediated Lysine Acetyltransferase Activity and Prevents Replication of the Parasite Toxoplasma gondii
Q59178755Gene knock-outs and allelic replacements in Toxoplasma gondii: HXGPRT as a selectable marker for hit-and-run mutagenesis
Q30994423Genomic data reveal Toxoplasma gondii differentiation mutants are also impaired with respect to switching into a novel extracellular tachyzoite state
Q73296757Growth of and competition between Neospora caninum and Toxoplasma gondii in vitro
Q92720553HIV-Related Cerebral Toxoplasmosis Revisited: Current Concepts and Controversies of an Old Disease
Q34725225High-throughput growth assay for Toxoplasma gondii using yellow fluorescent protein
Q61806726Host Cell Metabolism Contributes to Delayed-Death Kinetics of Apicoplast Inhibitors in Toxoplasma gondii
Q43982266Identification and characterization of differentiation mutants in the protozoan parasite Toxoplasma gondii
Q33872108Impact of a plastid-bearing endocytobiont on apicomplexan genomes.
Q40425386In vitro evaluation of the effectiveness of the macrolide rokitamycin and chlorpromazine against Acanthamoeba castellanii
Q32062673In vitro quantitative analysis of (3)H-uracil incorporation by Sarcocytis neurona to determine efficacy of anti-protozoal agents
Q37109789Infection with Toxoplasma gondii results in dysregulation of the host cell cycle
Q45296496Intravitreal clindamycin plus dexamethasone versus classic oral therapy in toxoplasmic retinochoroiditis: a prospective randomized clinical trial
Q35648606Lincomycin, clindamycin and their applications
Q35964967Lincosamides: chemical structure, biosynthesis, mechanism of action, resistance, and applications
Q37868313Lower respiratory tract infections in cats: reaching beyond empirical therapy
Q28538285Lysine acetyltransferase GCN5b interacts with AP2 factors and is required for Toxoplasma gondii proliferation
Q36577718Macrolides and associated antibiotics based on similar mechanism of action like lincosamides in malaria
Q38068970Medicinal potential of ciprofloxacin and its derivatives
Q37749058Metabolic pathways in the apicoplast of apicomplexa.
Q35213000Mining the Plasmodium genome database to define organellar function: what does the apicoplast do?
Q36095096Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast
Q33815675Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii
Q37992089New antibacterials for the treatment of toxoplasmosis; a patent review
Q53537659New comprehension of the apicoplast of Sarcocystis by transmission electron tomography.
Q58828669Non-Antifolate Antibiotics: Clindamycin, Doxycycline, Azithromycin and Fosmidomycin
Q46645614Organellar dynamics during the cell cycle of Toxoplasma gondii.
Q33718406Origin, targeting, and function of the apicomplexan plastid
Q38972996Pantothenic acid biosynthesis in the parasite Toxoplasma gondii: a target for chemotherapy.
Q27312274Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis
Q34182794Phosphorylation of eukaryotic initiation factor-2α promotes the extracellular survival of obligate intracellular parasite Toxoplasma gondii
Q39422863Protein Degradation Systems as Antimalarial Therapeutic Targets
Q34593987Recent advances in the search for new anti-coccidial drugs
Q39142182Regulation of ATG8 membrane association by ATG4 in the parasitic protist Toxoplasma gondii
Q30043256Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum
Q34488213Subcellular localization of acetyl-CoA carboxylase in the apicomplexan parasite Toxoplasma gondii
Q48022900Targeted Phenotypic Screening in Plasmodium falciparum and Toxoplasma gondii Reveals Novel Modes of Action of Medicines for Malaria Venture Malaria Box Molecules.
Q35805373Targeted disruption of Toxoplasma gondii serine protease inhibitor 1 increases bradyzoite cyst formation in vitro and parasite tissue burden in mice
Q78168444Targeted reduction of nucleoside triphosphate hydrolase by antisense RNA inhibits Toxoplasma gondii proliferation
Q52348641TgTKL1 Is a Unique Plant-Like Nuclear Kinase That Plays an Essential Role in Acute Toxoplasmosis.
Q44898755The apicoplast as a potential therapeutic target in Toxoplasma and other apicomplexan parasites: some additional thoughts
Q43906091The apicoplast as a potential therapeutic target in and other apicomplexan parasites
Q46386660The apicoplast of Plasmodium falciparum is translationally active.
Q34533262The apicoplast: A plastid in Plasmodium falciparum and other apicomplexan parasites
Q29544118The apicoplast: a new member of the plastid family
Q56911719The effects of nitidine chloride and camptothecin on the growth of Babesia and Theileria parasites
Q42725813The in vitro development of Neospora caninum bradyzoites
Q27349108The motility of a human parasite, Toxoplasma gondii, is regulated by a novel lysine methyltransferase
Q34038501The plastid in Apicomplexa: what use is it?
Q36293658The plastid of Toxoplasma gondii is divided by association with the centrosomes
Q37942263Therapy for ocular toxoplasmosis.
Q37703340Toxoplasma gondii AP2IX-4 Regulates Gene Expression during Bradyzoite Development
Q33765729Toxoplasma gondii bradyzoites form spontaneously during sporozoite-initiated development
Q74769472Toxoplasma gondii in vitro culture for experimentation
Q35538988Toxoplasma gondii nucleus coding apicoplast protein ACP synthesis and trafficking in delayed death
Q31028361Translocation of ribosomal protein P0 onto the Toxoplasma gondii tachyzoite surface
Q77377954Treatment protocol determines the efficacy of clindamycin in acute murine toxoplasmosis
Q30080014Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast
Q35137900Use of Toxoplasma gondii expressing beta-galactosidase for colorimetric assessment of drug activity in vitro
Q48015411Validation of Putative Apicoplast-Targeting Drugs Using a Chemical Supplementation Assay in Cultured Human Malaria Parasites.
Q30045658Validation of isoleucine utilization targets in Plasmodium falciparum

Search more.