The role of CCL21/CCR7 chemokine axis in breast cancer-induced lymphangiogenesis

scientific article

The role of CCL21/CCR7 chemokine axis in breast cancer-induced lymphangiogenesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1035617051
P356DOI10.1186/S12943-015-0306-4
P932PMC publication ID4339430
P698PubMed publication ID25744065
P5875ResearchGate publication ID272364743

P2093author name stringPeeyush K Lala
Mousumi Majumder
Xiping Xin
Elena Tutunea-Fatan
P2860cites workInvolvement of chemokine receptors in breast cancer metastasisQ24290909
Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13Q24319684
COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancerQ24651871
Lymph vessel density correlates with nodal status, VEGF-C expression, and prognosis in breast cancerQ81709785
[Role of CCL21/CCR7 in invasion of colorectal carcinoma cell line SW480]Q84276512
Clinical significance of vascular endothelial growth factors C and D and chemokine receptor CCR7 in gastric cancerQ84586867
VEGF-C promotes immune tolerance in B16 melanomas and cross-presentation of tumor antigen by lymph node lymphaticsQ84621185
Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFR.Q40399380
Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vesselsQ40414498
PGE2-mediated upregulation of iNOS in murine breast cancer cells through the activation of EP4 receptors.Q40611334
Cyclooxygenase inhibitors retard murine mammary tumor progression by reducing tumor cell migration, invasiveness and angiogenesisQ40789590
Measuring single-cell cytosolic Ca2+ concentration in response to proteoglycansQ40792959
CC chemokine receptor-3 undergoes prolonged ligand-induced internalizationQ40959278
Effect of CCR7, CXCR4 and VEGF-C on the lymph node metastasis of human pancreatic ductal adenocarcinomaQ42149105
Role of prostaglandin E2 receptors in migration of murine and human breast cancer cells.Q42450323
Chemotrap-1: an engineered soluble receptor that blocks chemokine-induced migration of metastatic cancer cells in vivoQ42590931
Vascular endothelial growth factor C expression and lymph node metastasis are regulated by the type I insulin-like growth factor receptor.Q44370178
Autocrine and paracrine chemokine receptor 7 activation in head and neck cancer: implications for therapyQ46684018
Cyclooxygenase-2 up-regulates CCR7 expression via AKT-mediated phosphorylation and activation of Sp1 in breast cancer cells.Q46782214
Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancerQ48575675
Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growthQ56825474
Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasisQ57382204
The expression of chemokines CCL19, CCL21 and their receptor CCR7 in oral squamous cell carcinoma and its relevance to cervical lymph node metastasisQ59387633
Chemokine-mediated migration of melanoma cells towards lymphatics--a mechanism contributing to metastasisQ79387215
CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancerQ81098644
Immunomodulatory roles of lymphatic vessels in cancer progressionQ27000429
Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasisQ28200101
Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinomaQ28205337
Identification and characterization of a novel beta chemokine containing six conserved cysteinesQ28246202
Cancer and the chemokine networkQ28269751
Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signalingQ28305764
Chemokines as mediators of neovascularizationQ30438032
CCL21 chemokine regulates chemokine receptor CCR7 bearing malignant melanoma cells.Q33201297
Correlation effect of EGFR and CXCR4 and CCR7 chemokine receptors in predicting breast cancer metastasis and prognosisQ33751824
CCL21 Cancer ImmunotherapyQ33820300
CCL21/CCR7 promotes G2/M phase progression via the ERK pathway in human non-small cell lung cancer cellsQ33940793
Cyclooxygenase-2-dependent lymphangiogenesis promotes nodal metastasis of postpartum breast cancerQ34128977
CCL21/CCR7 prevents apoptosis via the ERK pathway in human non-small cell lung cancer cellsQ34206158
Co-expression of α9β1 integrin and VEGF-D confers lymphatic metastatic ability to a human breast cancer cell line MDA-MB-468LN.Q34251088
Lymphangiogenesis and cancerQ36137692
Migration-promoting role of VEGF-C and VEGF-C binding receptors in human breast cancer cells.Q36611431
Tuning inflammation and immunity by chemokine sequestration: decoys and moreQ36662451
A key role for CCR7 in establishing central and peripheral toleranceQ36803195
Pre-clinical characterization of GMP grade CCL21-gene modified dendritic cells for application in a phase I trial in non-small cell lung cancerQ36828493
Organ selectivity in metastasis: regulation by chemokines and their receptorsQ36949936
Lymphangiogenesis: in vitro and in vivo modelsQ37591047
Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancyQ37772365
Role of lymphatic vessels in tumor immunity: passive conduits or active participants?Q37787865
Chemokines as targets for therapyQ37849900
Biological basis of therapeutic lymphangiogenesis.Q37858861
Lymphangiogenesis and lymphatic vessel remodelling in cancerQ38190359
A practical and sensitive method of quantitating lymphangiogenesis in vivoQ39146947
Targeting COX-2 and EP4 to control tumor growth, angiogenesis, lymphangiogenesis and metastasis to the lungs and lymph nodes in a breast cancer modelQ39340968
The chemotactic interaction between CCL21 and its receptor, CCR7, facilitates the progression of pancreatic cancer via induction of angiogenesis and lymphangiogenesisQ39540035
Relationship between cyclooxygenase-2 and human epidermal growth factor receptor 2 in vascular endothelial growth factor C up-regulation and lymphangiogenesis in human breast cancer.Q39683398
Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21.Q39722616
Mammalian target of rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma of the head and neckQ39823803
Vascular endothelial growth factor-C and C-C chemokine receptor 7 in tumor cell-lymphatic cross-talk promote invasive phenotypeQ39899648
Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells.Q40005941
Expression patterns of lymphangiogenic and angiogenic factors in a model of breast ductal carcinoma in situQ40067837
Expression and function of the chemokine receptor CCR7 in thyroid carcinomas.Q40215535
Generation and characterization of a mouse lymphatic endothelial cell line.Q40305468
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P921main subjectlymphangiogenesisQ6708231
P304page(s)35
P577publication date2015-02-10
P1433published inMolecular CancerQ15724585
P1476titleThe role of CCL21/CCR7 chemokine axis in breast cancer-induced lymphangiogenesis
P478volume14

Reverse relations

cites work (P2860)
Q57106000Alterations of Signaling Pathways Related to the Immune System in Breast Cancer: New Perspectives in Patient Management
Q36370199CCL21-CCR7 promotes the lymph node metastasis of esophageal squamous cell carcinoma by up-regulating MUC1.
Q33788042CCL21/CCR7 interaction promotes cellular migration and invasion via modulation of the MEK/ERK1/2 signaling pathway and correlates with lymphatic metastatic spread and poor prognosis in urinary bladder cancer
Q37392868CCL5 promotes VEGF-C production and induces lymphangiogenesis by suppressing miR-507 in human chondrosarcoma cells
Q42409232CCR7 Maintains Nonresolving Lymph Node and Adipose Inflammation in Obesity
Q33679655CCR7 mediates human breast cancer cell invasion, migration by inducing epithelial-mesenchymal transition and suppressing apoptosis through AKT pathway.
Q41439903CCR7 promote lymph node metastasis via regulating VEGF-C/D-R3 pathway in lung adenocarcinoma
Q55667705CCR7 regulates ANO6 to promote migration of pancreatic ductal adenocarcinoma cells via the ERK signaling pathway.
Q33593895Chemokine (C-C motif) receptor 7 (CCR7) associates with the tumour immune microenvironment but not progression in invasive breast carcinoma
Q52723037Chemokine CCL4 Induces Vascular Endothelial Growth Factor C Expression and Lymphangiogenesis by miR-195-3p in Oral Squamous Cell Carcinoma.
Q51472977Chemokine axes in breast cancer: factors of the tumor microenvironment reshape the CCR7-driven metastatic spread of luminal-A breast tumors.
Q49634148Chemokines in homeostasis and diseases
Q64963036Comparing progression molecular mechanisms between lung adenocarcinoma and lung squamous cell carcinoma based on genetic and epigenetic networks: big data mining and genome-wide systems identification.
Q38778516Construction of specific magnetic resonance imaging/optical dual-modality molecular probe used for imaging angiogenesis of gastric cancer
Q42293590ELM: A New, Simple, and Economic Assay to Measure Motility of Lymphatic Endothelial Cells
Q37116507Expression of CCL21 in Ewing sarcoma shows an inverse correlation with metastases and is a candidate target for immunotherapy.
Q90115310Expression pattern of CDK12 protein in gastric cancer and its positive correlation with CD8+ cell density and CCL12 expression
Q35980816G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis
Q59136348Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration
Q90484486Immune and Stroma Related Genes in Breast Cancer: A Comprehensive Analysis of Tumor Microenvironment Based on the Cancer Genome Atlas (TCGA) Database
Q99590808Increased expression of cystathionine beta-synthase and chemokine ligand 21 is closely associated with poor prognosis in extrahepatic cholangiocarcinoma
Q92358706Inhibition of Tumor Lymphangiogenesis is an Important Part that EGFR-TKIs Play in the Treatment of NSCLC
Q91586391Matrine induces apoptosis via targeting CCR7 and enhances the effect of anticancer drugs in non-small cell lung cancer in vitro
Q64099517Meta-analysis of the prognostic value of C-C chemokine receptor type 7 in patients with solid tumors
Q90289909MicroRNA-532-3p Suppresses Malignant Behaviors of Tongue Squamous Cell Carcinoma via Regulating CCR7
Q91657950Mir526b and Mir655 Promote Tumour Associated Angiogenesis and Lymphangiogenesis in Breast Cancer
Q36241115PGE2 promotes breast cancer-associated lymphangiogenesis by activation of EP4 receptor on lymphatic endothelial cells
Q37124521Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis
Q64277308Prognostic value of immunoexpression of CCR4, CCR5, CCR7 and CXCR4 in squamous cell carcinoma of tongue and floor of the mouth
Q49887925Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges
Q37738074Role of tumor microenvironment in tumorigenesis
Q36375142Silencing of CCR7 inhibits the growth, invasion and migration of prostate cancer cells induced by VEGFC
Q38992680Stromal contributions to the carcinogenic process
Q28076945The dual role of tumor lymphatic vessels in dissemination of metastases and immune response development
Q33761936Tumor hypoxia modulates podoplanin/CCL21 interactions in CCR7+ NK cell recruitment and CCR7+ tumor cell mobilization
Q36183239miR-199a-5p suppresses human bladder cancer cell metastasis by targeting CCR7.

Search more.