Crystal structure of snake venom acetylcholinesterase in complex with inhibitory antibody fragment Fab410 bound at the peripheral site: evidence for open and closed states of a back door channel

scientific article

Crystal structure of snake venom acetylcholinesterase in complex with inhibitory antibody fragment Fab410 bound at the peripheral site: evidence for open and closed states of a back door channel is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M114.603902
P932PMC publication ID4340399
P698PubMed publication ID25411244

P50authorPascale MarchotQ28324823
Ludovic RenaultQ42846004
P2093author name stringYves Bourne
P2860cites work[Acetylcholinesterase from snake venoms]Q73693989
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Characterization of Monoclonal Antibodies that Strongly Inhibit Electrophorus Electricus AcetylcholinesteraseQ71994354
Fasciculin 2 Binds to the Peripheral Site on Acetylcholinesterase and Inhibits Substrate Hydrolysis by Slowing a Step Involving Proton Transfer during Enzyme AcylationQ71996658
The "back door" hypothesis for product clearance in acetylcholinesterase challenged by site-directed mutagenesisQ72808598
Acetylcholinesterases from Elapidae snake venoms: biochemical, immunological and enzymatic characterizationQ73424853
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectsnake venomQ424200
P304page(s)1522-1535
P577publication date2014-11-19
P1433published inJournal of Biological ChemistryQ867727
P1476titleCrystal structure of snake venom acetylcholinesterase in complex with inhibitory antibody fragment Fab410 bound at the peripheral site: evidence for open and closed states of a back door channel
P478volume290

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cites work (P2860)
Q90190303A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides
Q38630724Computational Studies on Acetylcholinesterases.
Q47218668Hot Spots for Protein Partnerships at the Surface of Cholinesterases and Related α/β Hydrolase Fold Proteins or Domains-A Structural Perspective
Q55709846Identification of new allosteric sites and modulators of AChE through computational and experimental tools.
Q46025102Immunopurification of Acetylcholinesterase from Red Blood Cells for Detection of Nerve Agent Exposure.
Q39306292Recent developments in structural studies on acetylcholinesterase
Q48020171Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance

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