A modified thymine for the synthesis of site-specific thymine-guanine DNA interstrand crosslinks

scientific article

A modified thymine for the synthesis of site-specific thymine-guanine DNA interstrand crosslinks is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKL587
P932PMC publication ID1636361
P698PubMed publication ID16945959
P5875ResearchGate publication ID6842876

P2093author name stringOrlando D Schärer
Jawad Alzeer
P2860cites workRegioselective synthesis of 1,N(2)-etheno-2'-deoxyguanosine and its generation in oligomeric DNA.Q44478419
Mispair-aligned N3T-alkyl-N3T interstrand cross-linked DNA: synthesis and characterization of duplexes with interstrand cross-links of variable lengthsQ44998778
Efficient DNA interstrand cross-link formation from a nucleotide radicalQ46383285
A violation of the Swain-Scott principle, and not SN1 versus SN2 reaction mechanisms, explains why carcinogenic alkylating agents can form different proportions of adducts at oxygen versus nitrogen in DNA.Q53472599
Synthesis of a duplex oligonucleotide containing a nitrogen mustard interstrand DNA-DNA cross-link.Q54102738
Synthesis and structural characterization of the N2G-mitomycin C-N2G interstrand cross-link in a model synthetic 23 base pair oligonucleotide DNA duplexQ71746683
Synthesis of DNA Oligomers Possessing a Covalently Cross-Linked Watson-Crick Base Pair Model Financial support from the National Institutes of Health (Grant: NS 12108) is gratefully acknowledgedQ73794835
N(4)C-ethyl-N(4)C cross-linked DNA: synthesis and characterization of duplexes with interstrand cross-links of different orientationsQ77485880
Direct demonstration in synthetic oligonucleotides that N,N'-bis(2-chloroethyl)-nitrosourea cross links N1 of deoxyguanosine to N3 of deoxycytidine on opposite strands of duplex DNAQ78257359
Intracellular inducible alkylation system that exhibits antisense effects with greater potency and selectivity than the natural oligonucleotideQ83008686
Site-specific incorporation of N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-AAF) into oligonucleotides using modified 'ultra-mild' DNA synthesisQ24791546
Structural studies of an oligodeoxynucleotide containing a trimethylene interstrand cross-link in a 5'-(CpG) motif: model of a malondialdehyde cross-linkQ27633302
The emerging genetic and molecular basis of Fanconi anaemiaQ28199075
The Fanconi anaemia/BRCA pathwayQ28201371
Formation and repair of interstrand cross-links in DNAQ28296085
Active oligonucleotides incorporating alkylating an agent as potential sequence- and base selective modifier of gene expressionQ34211885
Chlorambucil drug resistance in chronic lymphocytic leukemia: the emerging role of DNA repairQ34215558
DNA interstrand cross-link formation initiated by reaction between singlet oxygen and a modified nucleotideQ34316272
Repair of DNA interstrand cross-linksQ34343361
Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance.Q34571928
Triplex-forming oligonucleotides: principles and applicationsQ34629430
Chemistry and biology of DNA repairQ35173709
Preparation of interstrand cross-linked DNA oligonucleotide duplexesQ35650848
Synthesis of 4-triazolopyrimidinone nucleotide and its application in synthesis of 5-methylcytosine-containing oligodeoxyribonucleotidesQ35746149
DNA interstrand crosslinks: natural and drug-induced DNA adducts that induce unique cellular responsesQ36002324
Covalent capture of a human O(6)-alkylguanine alkyltransferase-DNA complex using N(1),O(6)-ethanoxanthosine, a mechanism-based crosslinkerQ39229756
Some chemical aspects of dose-response relationships in alkylation mutagenesisQ39901479
The chloroethylnitrosoureas: sensitivity and resistance to cancer chemotherapy at the molecular levelQ41669418
Synthesis and characterization of DNA duplexes containing an N(4)C-ethyl-N(4)C interstrand cross-linkQ43687087
Efficient syntheses of 2-chloro-2'-deoxyadenosine (cladribine) from 2'-deoxyguanosine(1).Q44296802
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectthymineQ171973
P304page(s)4458-4466
P577publication date2006-08-31
P1433published inNucleic Acids ResearchQ135122
P1476titleA modified thymine for the synthesis of site-specific thymine-guanine DNA interstrand crosslinks
P478volume34

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cites work (P2860)
Q43162983Furan-modified oligonucleotides for fast, high-yielding and site-selective DNA inter-strand cross-linking with non-modified complements
Q37082772Generation of DNA interstrand cross-links by post-synthetic reductive amination
Q37121619Multinuclear NMR and kinetic analysis of DNA interstrand cross-link formation
Q36963219New synthetic substrates of mammalian nucleotide excision repair system
Q42140223Reversibly locked thionucleobase pairs in DNA to study base flipping enzymes
Q42571991Synthesis and characterization of an O(6)-2'-deoxyguanosine-alkyl-O(6)-2'-deoxyguanosine interstrand cross-link in a 5'-GNC motif and repair by human O(6)-alkylguanine-DNA alkyltransferase
Q42780227Synthesis and molecular modeling of a nitrogen mustard DNA interstrand crosslink
Q33791136Synthesis of structurally diverse major groove DNA interstrand crosslinks using three different aldehyde precursors
Q34132691Using synthetic DNA interstrand crosslinks to elucidate repair pathways and identify new therapeutic targets for cancer chemotherapy

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