U4 at the 3' UTR of PB1 segment of H5N1 influenza virus promotes RNA polymerase activity and contributes to viral pathogenicity

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U4 at the 3' UTR of PB1 segment of H5N1 influenza virus promotes RNA polymerase activity and contributes to viral pathogenicity is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...993366S
P356DOI10.1371/JOURNAL.PONE.0093366
P932PMC publication ID3968160
P698PubMed publication ID24676059
P5875ResearchGate publication ID261187122

P50authorYi HuQ84358549
Cheng-Feng QinQ37366846
P2093author name stringYu Zhang
Jing Li
Wei Sun
Tao Jiang
Pengfei Han
Yuchang Li
Yinhui Yang
Jiaming Li
Xiaoping Kang
Xiaoyan Wu
Qingyu Zhu
P2860cites workEfficient generation and growth of influenza virus A/PR/8/34 from eight cDNA fragmentsQ40551696
The position 4 nucleotide at the 3' end of the influenza virus neuraminidase vRNA is involved in temporal regulation of transcription and replication of neuraminidase RNAs and affects the repertoire of influenza virus surface antigensQ41014445
The structure of the hemagglutinin, a determinant for the pathogenicity of influenza virusesQ41595412
Roles of the influenza virus polymerase and nucleoprotein in forming a functional RNP structureQ41845291
Avian flu: H5N1 virus outbreak in migratory waterfowl.Q43177297
Highly pathogenic H5N1 influenza virus infection in migratory birdsQ43177302
The 3' and 5'-terminal sequences of influenza A, B and C virus RNA segments are highly conserved and show partial inverted complementarityQ45791400
Nonconserved nucleotides at the 3' and 5' ends of an influenza A virus RNA play an important role in viral RNA replicationQ95817746
The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cellsQ24676166
A single-nucleotide natural variation (U4 to C4) in an influenza A virus promoter exhibits a large structural change: implications for differential viral RNA synthesis by RNA-dependent RNA polymeraseQ27640489
Influenza A virus RNA polymerase has the ability to stutter at the polyadenylation site of a viral RNA template during RNA replicationQ27863651
Orthomyxovirus replication, transcription, and polyadenylation.Q27863791
The influenza virus panhandle is involved in the initiation of transcriptionQ27865309
Structure of influenza virus RNP. I. Influenza virus nucleoprotein melts secondary structure in panhandle RNA and exposes the bases to the solventQ28245490
Avian flu: influenza virus receptors in the human airwayQ29619374
Airborne transmission of influenza A/H5N1 virus between ferretsQ29619970
Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferretsQ29619972
Human infection with a novel avian-origin influenza A (H7N9) virusQ29620049
Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genomeQ30223081
Human and avian influenza viruses target different cell types in cultures of human airway epithelium.Q30341182
Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice.Q30365053
Importance of both the coding and the segment-specific noncoding regions of the influenza A virus NS segment for its efficient incorporation into virionsQ33737596
Lethal H5N1 influenza viruses escape host anti-viral cytokine responsesQ34146021
Strand-specific real-time RT-PCR for distinguishing influenza vRNA, cRNA, and mRNAQ34629197
Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western ChinaQ34651554
Virulence of H5N1 virus in mice attenuates after in vitro serial passagesQ34692977
Quercetin reduces susceptibility to influenza infection following stressful exerciseQ34789081
The influenza virus RNA synthesis machine: advances in its structure and functionQ37847896
PB1-mediated virulence attenuation of H5N1 influenza virus in mice is associated with PB2.Q39582914
Influenza virus genome C4 promoter/origin attenuates its transcription and replication activity by the low polymerase recognition activityQ39642782
Influenza virus A pathogenicity: the pivotal role of hemagglutininQ39665535
Secondary structure of the panhandle RNA of influenza virus A studied by NMR spectroscopyQ39717882
Virus-inducible reporter genes as a tool for detecting and quantifying influenza A virus replicationQ40431564
5′ and 3′ terminal nucleotide sequences of the RNA genome segments of influenza virusQ40502664
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)e93366
P577publication date2014-03-27
P1433published inPLOS OneQ564954
P1476titleU4 at the 3' UTR of PB1 segment of H5N1 influenza virus promotes RNA polymerase activity and contributes to viral pathogenicity
P478volume9

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cites work (P2860)
Q35566411Additional Evidence That the Polymerase Subunits Contribute to the Viral Replication and the Virulence of H5N1 Avian Influenza Virus Isolates in Mice
Q38959160PB2-E627K and PA-T97I substitutions enhance polymerase activity and confer a virulent phenotype to an H6N1 avian influenza virus in mice.
Q90745138The Role of Clinical Virology Laboratory and the Clinical Virology Laboratorian in Ensuring Effective Surveillance for Influenza and Other Respiratory Viruses: Points to Consider and Pitfalls to Avoid
Q64125157U13 → C13 mutation in the variable region of the NA gene 3'UTR of H9N2 influenza virus influences the replication and transcription of NA and enhances virus infectivity

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