Relevance of telomere/telomerase system impairment in early stage chronic lymphocytic leukemia

scientific article

Relevance of telomere/telomerase system impairment in early stage chronic lymphocytic leukemia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/GCC.22171
P698PubMed publication ID24706380
P5875ResearchGate publication ID261376477

P50authorPier Alberto BertazziQ30004136
Anna Grazia RecchiaQ37837458
Sonia FabrisQ39052038
Valentina BollatiQ40951527
Manlio FerrariniQ42322785
Giovanna CutronaQ54323503
Agostino CortelezziQ56461136
Antonino NeriQ56850455
Mirjam HoxhaQ75155238
P2093author name stringLuca Agnelli
Fortunato Morabito
Massimo Gentile
Serena Matis
P2860cites workPOT1 as a terminal transducer of TRF1 telomere length controlQ24302841
The human Rap1 protein complex and modulation of telomere lengthQ24337452
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeatsQ24339608
Telomere measurement by quantitative PCRQ24529938
Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesisQ24675780
Genomic aberrations and survival in chronic lymphocytic leukemiaQ28141442
Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT)Q28190909
Chronic lymphocytic leukemiaQ28236621
Protein composition of catalytically active human telomerase from immortal cellsQ28295708
Telomeres shorten during ageing of human fibroblastsQ29547357
How shelterin protects mammalian telomeresQ29615744
Replication protein A is an independent prognostic indicator with potential therapeutic implications in colon cancerQ33278718
The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcomeQ33290215
Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemiaQ33310158
Chromosome aberrations in B-cell chronic lymphocytic leukemia: reassessment based on molecular cytogenetic analysisQ33534356
CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease.Q33956997
T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhangQ34082359
Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by immunoglobulin V gene mutationsQ34264324
Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesisQ34535672
Cancer chromosomes going to POT1Q34688221
Telomere length modulation in human astroglial brain tumorsQ34731430
Telomere length is an independent predictor of survival, treatment requirement and Richter's syndrome transformation in chronic lymphocytic leukemia.Q34973576
Telomere length and telomerase levels delineate subgroups of B-cell chronic lymphocytic leukemia with different biological characteristics and clinical outcomesQ35643026
From RPA to BRCA2: lessons from single-stranded DNA binding by the OB-foldQ35753202
Biological and clinical relevance of quantitative global methylation of repetitive DNA sequences in chronic lymphocytic leukemiaQ37179155
Walking the walk from genes through telomere maintenance to cancer riskQ37860824
Epigenetic regulation of telomeres in human cancer.Q39944681
Alterations in DNA methylation may play a variety of roles in carcinogenesisQ40410595
Chromosome 2p gain in monoclonal B-cell lymphocytosis and in early stage chronic lymphocytic leukemia.Q44447816
Definition of progression risk based on combinations of cellular and molecular markers in patients with Binet stage A chronic lymphocytic leukaemiaQ47812640
A clinical staging system for chronic lymphocytic leukemia: prognostic significance.Q50994335
Short telomere length is associated with NOTCH1/SF3B1/TP53 aberrations and poor outcome in newly diagnosed chronic lymphocytic leukemia patients.Q51039630
Telomeres and chromosomal instability in chronic lymphocytic leukemia.Q54491927
Telomere length, molecular cytogenetic findings, and immunophenotypic features in previously untreated patients with B-chronic lymphocytic leukemia.Q54683825
ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.Q55036524
Telomerase expression in B-cell chronic lymphocytic leukemia predicts survival and delineates subgroups of patients with the same igVH mutation status and different outcomeQ58276318
Telomeres and prognosis in patients with chronic lymphocytic leukaemiaQ60345319
Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomasQ74083209
Telomere length identifies two different prognostic subgroups among VH-unmutated B-cell chronic lymphocytic leukemia patientsQ79777424
Short telomeres are associated with genetic complexity, high-risk genomic aberrations, and short survival in chronic lymphocytic leukemiaQ80112597
Telomere length, cigarette smoking, and bladder cancer risk in men and womenQ80117490
Telomere length as a prognostic parameter in chronic lymphocytic leukemia with special reference to VH gene mutation statusQ81474867
Telomeric damage in early stage of chronic lymphocytic leukemia correlates with shelterin dysregulationQ83484155
P433issue7
P921main subjectlymphocyteQ715347
P304page(s)612-621
P577publication date2014-04-04
P1433published inGenes, Chromosomes and CancerQ5532697
P1476titleRelevance of telomere/telomerase system impairment in early stage chronic lymphocytic leukemia
P478volume53

Reverse relations

cites work (P2860)
Q420427593R gene expression in chronic lymphocytic leukemia reveals insight into disease evolution
Q26738706Aberrant Promoter Hypomethylation in CLL: Does It Matter for Disease Development?
Q42371573Alterations in DNA methylation/demethylation intermediates predict clinical outcome in chronic lymphocytic leukemia
Q28389928Association between Long Interspersed Nuclear Element-1 Methylation and Relative Telomere Length in Wilms Tumor
Q57171710DNA Methylation of Telomere-Related Genes and Cancer Risk
Q35772403Differential Expression of Non-Shelterin Genes Associated with High Telomerase Levels and Telomere Shortening in Plasma Cell Disorders
Q33860001Dysregulation of H/ACA ribonucleoprotein components in chronic lymphocytic leukemia
Q37225819Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia
Q40341051Hypoxia pathway genetic variants predict survival of non-small-cell lung cancer patients receiving platinum-based chemotherapy
Q47635411Identifying the biomarker potential of telomerase activity and shelterin complex molecule, telomeric repeat binding factor 2 (TERF2), in multiple myeloma
Q89220608Leukocyte Telomere Length Shortening, hTERT Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia
Q38784976Prognostic role of telomere length in malignancies: A meta-analysis and meta-regression
Q42348459Role of miR-15a/miR-16-1 and the TP53 axis in regulating telomerase expression in chronic lymphocytic leukemia
Q40485655T-cell acute lymphoblastic leukemia in infants has distinct genetic and epigenetic features compared to childhood cases
Q42250056Telomere length analysis in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia Binet A.
Q52941092Telomere shortening associated with increased genomic complexity in chronic lymphocytic leukemia.
Q50900368Telomere shortening, TP53 mutations and deletions in chronic lymphocytic leukemia result in increased chromosomal instability and breakpoint clustering in heterochromatic regions.
Q36093789Telomere status in chronic lymphocytic leukemia with TP53 disruption.
Q54980026The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair.
Q64979971Variability within the human TERT gene, telomere length and predisposition to chronic lymphocytic leukemia.
Q93152904miR-1293, a Candidate for miRNA-Based Cancer Therapeutics, Simultaneously Targets BRD4 and the DNA Repair Pathway

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