Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta

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Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta is …
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scholarly articleQ13442814

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P819ADS bibcode2003PNAS..100.6370H
P356DOI10.1073/PNAS.1237107100
P932PMC publication ID164453
P698PubMed publication ID12750461
P5875ResearchGate publication ID10757597

P2093author name stringMichio Sato
Kazuki Sato
Minako Hoshi
Akihiko Noguchi
Kaori Yasutake
Shinichiro Matsumoto
Natsuko Yoshida
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Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicityQ28378569
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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxinsQ29547593
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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseasesQ29616535
Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cellsQ29618245
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouseQ29619237
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A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's diseaseQ33292093
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Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell deathQ35052504
Intraneuronal Abeta42 accumulation in human brain.Q35793325
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.Q35969894
Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neuronsQ36324215
Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brainQ37672243
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Physiology and pathology of tau protein kinases in relation to Alzheimer's disease.Q41412181
Production of the Alzheimer amyloid beta protein by normal proteolytic processingQ41599298
Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solutionQ42153291
Cytotoxic amyloid peptides inhibit cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction by enhancing MTT formazan exocytosis.Q42447316
Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly stateQ44689258
Soluble amyloid Abeta-(1-40) exists as a stable dimer at low concentrationsQ46204569
A critical role for amino-terminal glutamine/asparagine repeats in the formation and propagation of a yeast prionQ46347783
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's diseaseQ47583762
Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapyQ47852610
Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.Q48093908
Lithium protects cultured neurons against beta-amyloid-induced neurodegenerationQ48163930
P433issue11
P407language of work or nameEnglishQ1860
P921main subjecttoxic encephalopathyQ7830379
neurotoxicityQ3338704
P304page(s)6370-6375
P577publication date2003-05-15
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleSpherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta
P478volume100

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