Quantitative phosphoproteomics of the ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-mutated and rad3-related (ATR) dependent DNA damage response in Arabidopsis thaliana

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Quantitative phosphoproteomics of the ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-mutated and rad3-related (ATR) dependent DNA damage response in Arabidopsis thaliana is …
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scholarly articleQ13442814

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P356DOI10.1074/MCP.M114.040352
P932PMC publication ID4349977
P698PubMed publication ID25561503
P5875ResearchGate publication ID270655945

P50authorKarl MechtlerQ28320558
Jianhua YangQ58336523
P2093author name stringThomas Köcher
Maria Novatchkova
Peter Pichler
Manuel Hofer
Elisabeth Roitinger
Peter Schlögelhofer
P2860cites workFunctional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extractsQ24300784
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damageQ24306743
PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitryQ24312535
PA200, a nuclear proteasome activator involved in DNA repairQ24536971
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinasesQ24632768
Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activityQ24644974
Common mechanisms of PIKK regulationQ24653672
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatinQ24672721
The Prp19/Pso4 core complex undergoes ubiquitylation and structural alterations in response to DNA damageQ24683438
Another fork in the road--life or death decisions by the tumour suppressor p53Q27026310
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexesQ27860662
ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complexQ27929959
Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repairQ27935229
DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139Q28131715
Wapl is an essential regulator of chromatin structure and chromosome segregationQ28585430
The PRoteomics IDEntifications (PRIDE) database and associated tools: status in 2013Q28710185
Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteinsQ29615270
Universal sample preparation method for proteome analysisQ29615662
An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data setsQ31016283
The transcriptional response of Arabidopsis to genotoxic stress - a high-density colony array study (HDCA).Q31156616
An "Electronic Fluorescent Pictograph" browser for exploring and analyzing large-scale biological data setsQ33293530
Mass spectrometry-based functional proteomics: from molecular machines to protein networksQ33300676
SIMAC (sequential elution from IMAC), a phosphoproteomics strategy for the rapid separation of monophosphorylated from multiply phosphorylated peptidesQ33307225
Co-expression and promoter content analyses assign a role in biotic and abiotic stress responses to plant natriuretic peptidesQ33321724
Suppressor of gamma response 1 (SOG1) encodes a putative transcription factor governing multiple responses to DNA damageQ33347320
Two Prp19-like U-box proteins in the MOS4-associated complex play redundant roles in plant innate immunityQ33486513
Ionizing radiation-dependent gamma-H2AX focus formation requires ataxia telangiectasia mutated and ataxia telangiectasia mutated and Rad3-relatedQ33768588
Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage responseQ33883063
Arabidopsis thaliana WAPL is essential for the prophase removal of cohesin during meiosisQ33916123
PlantPhos: using maximal dependence decomposition to identify plant phosphorylation sites with substrate site specificityQ33942498
The Arabidopsis AtLIG4 gene is required for the repair of DNA damage, but not for the integration of Agrobacterium T-DNAQ39792164
Correct interpretation of comprehensive phosphorylation dynamics requires normalization by protein expression changesQ42029542
The SCX/IMAC enrichment approach for global phosphorylation analysis by mass spectrometryQ42122474
ATM-mediated phosphorylation of SOG1 is essential for the DNA damage response in Arabidopsis.Q42154715
Identification of Arabidopsis VTC3 as a putative and unique dual function protein kinase::protein phosphatase involved in the regulation of the ascorbic acid pool in plantsQ43460826
Genetics and phosphoproteomics reveal a protein phosphorylation network in the abscisic acid signaling pathway in Arabidopsis thalianaQ43997052
Phosphorylation of histone H2A is associated with centromere function and maintenance in meiosisQ44111948
Severe developmental defects, hypersensitivity to DNA-damaging agents, and lengthened telomeres in Arabidopsis MRE11 mutantsQ44170735
AtATM is essential for meiosis and the somatic response to DNA damage in plantsQ44267791
ATR regulates a G2-phase cell-cycle checkpoint in Arabidopsis thalianaQ44838357
Universal and confident phosphorylation site localization using phosphoRS.Q45927182
TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia geneQ48070727
Characterization of the three Arabidopsis thaliana RAD21 cohesins reveals differential responses to ionizing radiationQ48099103
An Arabidopsis hAT-like transposase is essential for plant development.Q48129662
Arabidopsis UVH3 gene is a homolog of the Saccharomyces cerevisiae RAD2 and human XPG DNA repair genesQ48355114
Mitogen-activated protein kinases 3 and 6 are required for full priming of stress responses in Arabidopsis thalianaQ51752292
Arabidopsis REF6 is a histone H3 lysine 27 demethylaseQ51865126
Growth stage-based phenotypic analysis of Arabidopsis: a model for high throughput functional genomics in plantsQ52132695
Glutathione deficiency of the Arabidopsis mutant pad2-1 affects oxidative stress-related events, defense gene expression, and the hypersensitive response.Q52729258
Both ATM and ATR promote the efficient and accurate processing of programmed meiotic double-strand breaksQ53481054
The Arabidopsis SKP1 homolog ASK1 controls meiotic chromosome remodeling and release of chromatin from the nuclear membrane and nucleolusQ53602509
CK2-defective Arabidopsis plants exhibit enhanced double-strand break repair rates and reduced survival after exposure to ionizing radiation.Q54518603
Guide to the Book Plant KinasesQ54568189
High Precision Quantitative Proteomics Using iTRAQ on an LTQ Orbitrap: A New Mass Spectrometric Method Combining the Benefits of AllQ57184382
Reproducible isolation of distinct, overlapping segments of the phosphoproteomeQ57205837
Participation of chromatin-remodeling proteins in the repair of ultraviolet-B-damaged DNAQ63000657
Mre11 deficiency in Arabidopsis is associated with chromosomal instability in somatic cells and Spo11-dependent genome fragmentation during meiosisQ64388931
ATR and ATM play both distinct and additive roles in response to ionizing radiationQ79570664
Quantitative phosphoproteome profiling of iron-deficient Arabidopsis rootsQ83719567
Mass spectrometry–based proteomics in cell biologyQ34083139
In planta changes in protein phosphorylation induced by the plant hormone abscisic acidQ34115712
ATM Activation by Oxidative StressQ34145092
p53 post-translational modification: deregulated in tumorigenesisQ34300569
Causes and consequences of replication stressQ34394094
Functional and transcriptome analysis reveals an acclimatization strategy for abiotic stress tolerance mediated by Arabidopsis NF-YA family members.Q34464795
DNA double-strand break repair: all's well that ends wellQ34555274
Protein kinase CK2: a challenge to canonsQ34875408
Involvement of the Arabidopsis SWI2/SNF2 chromatin remodeling gene family in DNA damage response and recombinationQ34895360
Protein kinase CK2: structure, regulation and role in cellular decisions of life and deathQ34978734
ATM deficiency and oxidative stress: a new dimension of defective response to DNA damageQ35037470
Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thalianaQ35200713
The Arabidopsis SKP1-LIKE1 gene is essential for male meiosis and may control homologue separationQ35650136
ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesisQ35874528
Proteome-wide identification of in vivo targets of DNA damage checkpoint kinasesQ35973264
SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteinsQ36072177
Modification site localization scoring: strategies and performanceQ36163477
Rapid phosphoproteomic and transcriptomic changes in the rhizobia-legume symbiosisQ36211819
The phosphoinositide-3-OH-kinase-related kinases of Arabidopsis thalianaQ36215808
Profiling of UV-induced ATM/ATR signaling pathways.Q36288898
Quantitative phosphoproteomics after auxin-stimulated lateral root induction identifies an SNX1 protein phosphorylation site required for growthQ36832458
Arabidopsis meiotic crossover hot spots overlap with H2A.Z nucleosomes at gene promotersQ37265483
DNA stress checkpoint control and plant developmentQ37325771
Proteomics approaches to understand protein phosphorylation in pathway modulationQ37680362
Decoding signalling networks by mass spectrometry-based proteomicsQ37749492
Strong cation exchange (SCX) based analytical methods for the targeted analysis of protein post-translational modificationsQ37798339
Advances in Quantitative PhosphoproteomicsQ37951536
Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaksQ38129612
CHD chromatin remodelling enzymes and the DNA damage response.Q38129665
The role of SOG1, a plant-specific transcriptional regulator, in the DNA damage response.Q38204878
DNA damage response in plants: conserved and variable response compared to animalsQ38212164
Characterization of the phosphoproteome of mature Arabidopsis pollen.Q38496919
Phosphoproteomic analysis of seed maturation in Arabidopsis, rapeseed, and soybeanQ38497839
Protein kinase CK2 is required for the recruitment of 53BP1 to sites of DNA double-strand break induced by radiomimetic drugs.Q39043983
P433issue3
P921main subjectArabidopsis thalianaQ158695
DNA damageQ5205747
P304page(s)556-571
P577publication date2015-01-05
P1433published inMolecular & Cellular ProteomicsQ6895932
P1476titleQuantitative phosphoproteomics of the ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-mutated and rad3-related (ATR) dependent DNA damage response in Arabidopsis thaliana
P478volume14