The genetics of common variation affecting platelet development, function and pharmaceutical targeting

scientific article

The genetics of common variation affecting platelet development, function and pharmaceutical targeting is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/J.1538-7836.2011.04359.X
P932PMC publication ID3151008
P698PubMed publication ID21781261
P5875ResearchGate publication ID51513612

P2093author name stringA D Johnson
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Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytesQ33384971
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Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte developmentQ34425414
Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysisQ34564576
Complex haplotypes derived from noncoding polymorphisms of the intronless alpha2A-adrenergic gene diversify receptor expressionQ34600291
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Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migrationQ37146658
A genome-wide association study identifies three loci associated with mean platelet volumeQ37156159
A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and functionQ37270690
Dynamin 3 participates in the growth and development of megakaryocytesQ37309541
The low-frequency isoform of platelet glycoprotein VIb attenuates ligand-mediated signal transduction but not receptor expression or ligand binding.Q37334622
A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregabilityQ37336145
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Sequence variants in three loci influence monocyte counts and erythrocyte volumeQ37417876
ABO-identical versus nonidentical platelet transfusion: a systematic reviewQ37630711
ACCF/AHA clopidogrel clinical alert: approaches to the FDA "boxed warning": a report of the American College of Cardiology Foundation Task Force on clinical expert consensus documents and the American Heart Association endorsed by the Society for CaQ37773051
Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activationQ38327516
Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantationQ38375573
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Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studiesQ41735608
The Gi-coupled P2Y12 receptor regulates diacylglycerol-mediated signaling in human platelets.Q41883110
Rap1b is critical for glycoprotein VI-mediated but not ADP receptor-mediated alpha2beta1 activationQ42079343
Effects of CYP2C19 genotype on outcomes of clopidogrel treatmentQ42846150
The PFA-100R cannot detect blood group-dependent inhibition of platelet function by eptifibatide or abciximab at therapeutic plasma concentrationsQ43178534
Influence of platelet size on outcome after myocardial infarctionQ43705998
The low-frequency allele of the platelet collagen signaling receptor glycoprotein VI is associated with reduced functional responses and expressionQ44298394
Subtype-selective antagonists of lysophosphatidic Acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaquesQ44529184
Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular diseaseQ44771742
PKC-theta selectively controls the adhesion-stimulating molecule Rap1.Q45124437
Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets.Q45974289
A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways.Q46017492
Mean platelet volume and the extent of coronary artery disease: results from a large prospective study.Q46019640
Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2.Q46190554
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Variables that affect platelet function analyzer-100 (PFA-100) closure times and establishment of reference intervals in Korean adults.Q46420093
Genetic and environmental influences on the size and number of cells in the bloodQ47229206
Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic strokeQ48324404
Human platelets as a substrate source for the in vitro amplification of the abnormal prion protein (PrP) associated with variant Creutzfeldt-Jakob diseaseQ48850540
Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach.Q51773327
Estimates of genetic and environmental contribution to 43 quantitative traits support sharing of a homogeneous environment in an isolated population from South Tyrol, Italy.Q53028824
The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans.Q53533032
The expression patterns of RGS transcripts in platelets.Q53585529
Transfer of differentiation signal by membrane microvesicles harboring hedgehog morphogens.Q53617685
An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia.Q55067329
Multivariate QTL linkage analysis suggests a QTL for platelet count on chromosome 19qQ56959481
High platelet volume and increased risk of myocardial infarction: 39 531 participants from the general populationQ58007630
P304page(s)246-257
P577publication date2011-07-01
P1433published inJournal of Thrombosis and HaemostasisQ6296004
P1476titleThe genetics of common variation affecting platelet development, function and pharmaceutical targeting
P478volume9 Suppl 1

Reverse relations

cites work (P2860)
Q37432574A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects
Q40618496Association of frequent genetic variants in platelet activation pathway genes with large-vessel ischemic stroke in Polish population.
Q35689156Cardiovascular correlates of platelet count and volume in the Framingham Heart Study
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Q34663589Genetic sequence analysis of inherited bleeding diseases
Q30840174Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia
Q40315017Platelet volume is associated with the Framingham risk score for cardiovascular disease in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
Q30276496Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals
Q38947978Replication and hematological characterization of human platelet reactivity genetic associations in men from the Caerphilly Prospective Study (CaPS).
Q39147666Standardization and reference intervals of platelet volume indices: Insight from the Brazilian longitudinal study of adult health (ELSA-BRASIL).
Q33442981The genetics of platelet count and volume in humans.
Q50673868Whole exome sequencing in the Framingham Heart Study identifies rare variation in HYAL2 that influences platelet aggregation.

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