HIV-1 tat protein induces a migratory phenotype in human fetal microglia by a CCL2 (MCP-1)-dependent mechanism: possible role in NeuroAIDS

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HIV-1 tat protein induces a migratory phenotype in human fetal microglia by a CCL2 (MCP-1)-dependent mechanism: possible role in NeuroAIDS is …
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scholarly articleQ13442814

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P356DOI10.1002/GLIA.20137
P932PMC publication ID4350669
P698PubMed publication ID15578658

P2093author name stringEliseo A Eugenin
Joan W Berman
Tina M Calderon
Gawain Dyer
P2860cites workChemokine and chemokine-receptor expression in human glial elements: induction by the HIV protein, Tat, and chemokine autoregulationQ22253485
MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosisQ24301992
HIV-1 Tat protein mimicry of chemokinesQ24644383
Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytesQ24683736
Cell migration: a physically integrated molecular processQ27860682
Multiple actions of the human immunodeficiency virus type-1 Tat protein on microglial cell functionsQ28261344
Getting membrane flow and the cytoskeleton to cooperate in moving cellsQ28297410
Microglia: a sensor for pathological events in the CNSQ29620556
Molecular pathway involved in HIV-1-induced CNS pathology: role of viral regulatory protein, Tat.Q33594713
HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levelsQ34161535
Crosstalk between components of the blood brain barrier and cells of the CNS in microglial activation in AIDS.Q34287122
Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1.Q34290308
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Chemokine receptor 2 (CCR2) in atherosclerosis, infectious diseases, and regulation of T-cell polarizationQ35173616
Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acidQ35605220
CD40-CD40L interactions induce chemokine expression by human microglia: implications for human immunodeficiency virus encephalitis and multiple sclerosisQ35747327
Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritisQ35821357
Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells.Q35879801
Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementiaQ35980114
Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivationQ36639380
Infection of brain microglial cells by human immunodeficiency virus type 1 is CD4 dependentQ36680041
Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patientsQ37400137
Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesionsQ37532544
Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's diseaseQ40870408
Microglia in degenerative neurological disease.Q40870414
Chemokines induce migration and changes in actin polymerization in adult rat brain microglia and a human fetal microglial cell line in vitroQ40980153
Moving membrane up to the front of migrating cellsQ41000793
Chemokine receptors: gateways to inflammation and infectionQ41193992
Polarization of chemokine receptors to the leading edge during lymphocyte chemotaxisQ42951587
Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors.Q43540455
Diazepam inhibits HIV-1 Tat-induced migration of human microgliaQ43753778
Production of monocyte chemoattractant protein-1 by inflamed synovial tissue and cultured synoviocytesQ43757508
Beta-chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementiaQ44253971
Diffuse microgliosis associated with cerebral atrophy in the acquired immunodeficiency syndromeQ44654994
Human CD8+ T cells store RANTES in a unique secretory compartment and release it rapidly after TcR stimulationQ44771104
Rapid chemokine secretion from endothelial cells originates from 2 distinct compartmentsQ44814425
Expression of chemokines by human fetal microglia after treatment with the human immunodeficiency virus type 1 protein Tat.Q45625995
Chemotaxis by a CNS macrophage, the microgliaQ46445651
HIV-1 Tat induces monocyte chemoattractant protein-1-mediated monocyte transmigration across a model of the human blood-brain barrier and up-regulates CCR5 expression on human monocytesQ48132643
Transient exposure to HIV-1 Tat protein results in cytokine production in macrophages and astrocytes. A hit and run phenomenonQ48192959
Epidermal growth factor is a motility factor for microglial cells in vitro: evidence for EGF receptor expressionQ48646011
Motility and ramification of human fetal microglia in culture: an investigation using time-lapse video microscopy and image analysisQ48682954
Microglia: Intrinsic immuneffector cell of the brainQ56029409
Complement 5a controls motility of murine microglial cells in vitro via activation of an inhibitory G-protein and the rearrangement of the actin cytoskeletonQ71538959
Production and function of monocyte chemoattractant protein-1 and other β-chemokines in murine glial cellsQ71977731
Differential production of and migratory response to beta chemokines by human microglia and astrocytesQ73467423
The total chemical synthesis of monocyte chemotactic protein-1 (MCP-1)Q73514523
Differential chemokine receptor expression and function in human monocyte subpopulationsQ73792772
Divergent regulation of HIV-1 replication in PBMC of infected individuals by CC chemokines: suppression by RANTES, MIP-1alpha, and MCP-3, and enhancement by MCP-1Q74310707
Cultured rat microglia express functional beta-chemokine receptorsQ78074648
P433issue4
P921main subjectHIV/AIDSQ12199
HIVQ15787
phenotypeQ104053
microgliaQ1622829
P304page(s)501-510
P577publication date2005-03-01
P1433published inGliaQ15716658
P1476titleHIV-1 tat protein induces a migratory phenotype in human fetal microglia by a CCL2 (MCP-1)-dependent mechanism: possible role in NeuroAIDS
P478volume49

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