Isolation and optimization for affinity and biophysical characteristics of anti-CCL17 antibodies from the VH1-69 germline gene

scientific article

Isolation and optimization for affinity and biophysical characteristics of anti-CCL17 antibodies from the VH1-69 germline gene is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/PROTEIN/GZU012
P698PubMed publication ID24742503
P5875ResearchGate publication ID261756146

P2093author name stringYiqing Feng
Sandra Santulli-Marotto
John C Wheeler
Eilyn R Lacy
Brian Whitaker
Deidra Bethea
John W Kehoe
Ken Boakye
Mary H Ryan
P2860cites workAntigen Binding and Solubility Effects upon the Veneering of a Camel VHH in Framework-2 to Mimic a VHQ57838453
Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinasesQ24309618
A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutininQ27676298
Structural and genetic basis for development of broadly neutralizing influenza antibodiesQ27682070
Principles of protein-protein interactionsQ27860855
The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4Q28239606
Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseasesQ28253402
Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4Q28259171
Dominant forces in protein foldingQ29616390
Requirement of CCL17 for CCR7- and CXCR4-dependent migration of cutaneous dendritic cellsQ30494984
Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activityQ32156624
Sequence determinants of protein aggregation in human VH domainsQ33380007
De novo selection of high-affinity antibodies from synthetic fab libraries displayed on phage as pIX fusion proteinsQ33527620
Contribution of light chain residues to high affinity binding in an HIV-1 antibody explored by combinatorial scanning mutagenesisQ33592517
Rare antibodies from combinatorial libraries suggests an S.O.S. component of the human immunological repertoireQ33813643
Selection and maturation of antibodies by phage display through fusion to pIX.Q34355422
Exploring blocking assays using Octet, ProteOn, and Biacore biosensorsQ34911367
Challenges in the development of high protein concentration formulationsQ35763453
Immune markers and differential signaling networks in ulcerative colitis and Crohn's diseaseQ36125752
Design of therapeutic proteins with enhanced stability.Q37274488
Mechanisms of protein aggregationQ37515821
Engineering aggregation-resistant antibodiesQ37999048
The role of amino acid sequence in the self-association of therapeutic monoclonal antibodies: insights from coarse-grained modelingQ38422315
Coarse-grained modeling of the self-association of therapeutic monoclonal antibodiesQ38424194
Mechanisms of self-association of a human monoclonal antibody CNTO607.Q39292574
The role of the Th2 CC chemokine ligand CCL17 in pulmonary fibrosisQ40512631
Regulated production of the T helper 2-type T-cell chemoattractant TARC by human bronchial epithelial cells in vitro and in human lung xenograftsQ40812334
Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen.Q42944784
Prediction of aggregation prone regions of therapeutic proteinsQ43089095
Structure-based engineering of a monoclonal antibody for improved solubilityQ44381771
Establishing a link between amino acid sequences and self-associating and viscoelastic behavior of two closely related monoclonal antibodiesQ44528218
Reversible self-association of a concentrated monoclonal antibody solution mediated by Fab-Fab interaction that impacts solution viscosityQ46054883
Identification of differences in the specificity-determining residues of antibodies that recognize antigens of different size: implications for the rational design of antibody repertoires.Q47425669
Crystal structure of HEL4, a soluble, refoldable human V(H) single domain with a germ-line scaffoldQ47919372
CCL22 and CCL17 in rat radiation pneumonitis and in human idiopathic pulmonary fibrosis.Q54707337
P433issue6
P304page(s)199-206
P577publication date2014-04-16
P1433published inProtein Engineering Design and SelectionQ15762396
P1476titleIsolation and optimization for affinity and biophysical characteristics of anti-CCL17 antibodies from the VH1-69 germline gene
P478volume27

Reverse relations

cites work (P2860)
Q26766715Engineered IgG1-Fc--one fragment to bind them all
Q41472386Facile Affinity Maturation of Antibody Variable Domains Using Natural Diversity Mutagenesis
Q27002558Improving monoclonal antibody selection and engineering using measurements of colloidal protein interactions
Q35688643In vitro affinity maturation and characterization of anti-P24 antibody for HIV diagnostic assay
Q37501464Multivalent pIX phage display selects for distinct and improved antibody properties
Q35249355Principles and application of antibody libraries for infectious diseases.

Search more.