2-methoxyestradiol induces vasodilation by stimulating NO release via PPARγ/PI3K/Akt pathway.

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2-methoxyestradiol induces vasodilation by stimulating NO release via PPARγ/PI3K/Akt pathway. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1018902C
P356DOI10.1371/JOURNAL.PONE.0118902
P932PMC publication ID4351983
P698PubMed publication ID25748432
P5875ResearchGate publication ID273325384

P50authorXiaodong FuQ57046580
Tommaso SimonciniQ38543921
P2093author name stringJinghe Huang
Ping Li
Weiyu Chen
Shuhui Zheng
Yuhong Cui
Yongfu Zhang
P2860cites work2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancerQ50670774
2-Methoxyestradiol, an estradiol metabolite, inhibits neointima formation and smooth muscle cell growth via double blockade of the cell cycle.Q53616102
Effect of estradiol metabolites on prostacyclin synthesis in human endothelial cell culturesQ73035386
Recognition and neutralization of angiotensins I and II using an artificial nanogel receptor fabricated by ligand specificity determinant imprintingQ87182553
Testosterone promotes vascular endothelial cell migration via upregulation of ROCK-2/moesin cascadeQ24337249
Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trialQ29615226
Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinaseQ30439814
Molecular imaging of the initial inflammatory response in atherosclerosis: implications for early detection of diseaseQ30492960
Acute effects of 2-methoxyestradiol on endothelial aortic No release in male and ovariectomized female ratsQ33543461
Nongenomic inhibition of coronary constriction by 17ß-estradiol, 2-hydroxyestradiol, and 2-methoxyestradiolQ34021692
Molecular insights and therapeutic targets for diabetic endothelial dysfunctionQ34022332
Candidate genes and mechanisms for 2-methoxyestradiol-mediated vasoprotectionQ34502795
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsiaQ34656275
Cardiovascular pharmacology of estradiol metabolitesQ35600830
HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosisQ37236532
Potential vascular actions of 2-methoxyestradiolQ37385763
Endothelial dysfunction: the first step toward coronary arteriosclerosisQ37395620
Hydrogen sulfide: a new EDRF.Q37523189
2-Methoxyestradiol--biology and mechanism of actionQ37705613
Submaximal PPARγ activation and endothelial dysfunction: new perspectives for the management of cardiovascular disordersQ37992099
2-Methoxyestradiol, an endogenous estrogen metabolite, sensitizes radioresistant MCF-7/FIR breast cancer cells through multiple mechanismsQ38428685
Quercetin synergizes with 2-methoxyestradiol inhibiting cell growth and inducing apoptosis in human prostate cancer cellsQ39152157
The endogenous estradiol metabolite 2-methoxyestradiol reduces atherosclerotic lesion formation in female apolipoprotein E-deficient miceQ40221622
17β-estradiol induces vasorelaxation by stimulating endothelial hydrogen sulfide releaseQ44520623
2-Methoxyestradiol confers neuroprotection and inhibits a maladaptive HIF-1α response after traumatic brain injury in mice.Q45177122
Pharmacotherapy: Benefits of menopausal hormone therapy--timing is key.Q45753015
2-Methoxyestradiol attenuates hypertension and coronary vascular remodeling in spontaneously hypertensive ratsQ46245520
Inhibition of rat aortic smooth muscle contraction by 2-methoxyestradiolQ46384835
Effects in postmenopausal women of estradiol and medroxyprogesterone alone and combined on resistance artery function and endothelial morphology and movementQ46719150
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)e0118902
P577publication date2015-03-06
P1433published inPLOS OneQ564954
P1476title2-methoxyestradiol induces vasodilation by stimulating NO release via PPARγ/PI3K/Akt pathway
P478volume10

Reverse relations

cites work (P2860)
Q921591422-Methoxyestradiol Attenuates Angiotensin II-Induced Hypertension, Cardiovascular Remodeling, and Renal Injury
Q531761392-Methoxyestradiol prevents monocyte adhesion to vascular endothelial cells via downregulation of VCAM-1 expression.
Q92240832A Systems Pharmacology-Based Study of the Molecular Mechanisms of San Cao Decoction for Treating Hypertension
Q58737878Apolipoprotein A1 mimetic peptide ATI-5261 reverses arterial stiffness at late pregnancy and early postpartum in a COMT mouse model of preeclampsia
Q89179963Effects of the Catechol and Methoxy Metabolites of 17β-Estradiol on Nitric Oxide Production by Ovine Uterine Artery Endothelial Cells
Q92257238Estradiol Metabolism: Crossroads in Pulmonary Arterial Hypertension
Q38838312Inhibition of Autophagy Increases 2-Methoxyestradiol-Induced Cytotoxicity in SW1353 Chondrosarcoma Cells
Q88379121Tumor necrosis factor alfa and interleukin 1 alfa induced phosphorylation and degradation of inhibitory kappa B alpha are regulated by estradiol in endometrial cells

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