The secretome of endothelial progenitor cells promotes brain endothelial cell activity through PI3-kinase and MAP-kinase

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The secretome of endothelial progenitor cells promotes brain endothelial cell activity through PI3-kinase and MAP-kinase is …
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scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...995731D
P356DOI10.1371/JOURNAL.PONE.0095731
P932PMC publication ID3995762
P698PubMed publication ID24755675
P5875ResearchGate publication ID261800927

P50authorStefano Di SantoQ37839349
P2093author name stringAnna-Lena Fuchs
Hans Rudolf Widmer
Jennifer Staudigl
Stefanie Seiler
P2860cites workParacrine regulation of angiogenesis by different cell types in the aorta ring modelQ37920815
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Angiogenesis, neurogenesis and neuroplasticity in ischemic strokeQ41423822
Bone marrow-derived endothelial progenitor cells protect postischemic axons after traumatic brain injuryQ41820291
Role of paracrine factors in stem and progenitor cell mediated cardiac repair and tissue fibrosisQ41940674
Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesisQ42513510
Paracrine proangiopoietic effects of human umbilical cord blood-derived purified CD133+ cells--implications for stem cell therapies in regenerative medicineQ42854848
Human marrow-derived mesenchymal stromal cells decrease cisplatin renotoxicity in vitro and in vivo and enhance survival of mice post-intraperitoneal injectionQ42906411
Metabolite control of angiogenesis: angiogenic effect of citrateQ43855694
Improved quantification of angiogenesis in the rat aortic ring assayQ43863508
Vascular degeneration in Parkinson's disease.Q47256703
Paracrine factors secreted by endothelial progenitor cells prevent oxidative stress-induced apoptosis of mature endothelial cells.Q53336156
Paracrine effects influenced by cell culture medium and consequences on microvessel-like structures in cocultures of mesenchymal stem cells and outgrowth endothelial cells.Q54375645
Human umbilical cord blood mononuclear cell-conditioned media inhibits hypoxic-induced apoptosis in human coronary artery endothelial cells and cardiac myocytes by activation of the survival protein Akt.Q54455328
Human umbilical cord blood mononuclear cells activate the survival protein Akt in cardiac myocytes and endothelial cells that limits apoptosis and necrosis during hypoxia.Q54508747
High-resolution mass spectrometric analysis of the secretome from mouse lung endothelial progenitor cells.Q54620202
Endothelial progenitor cells may inhibit apoptosis of pulmonary microvascular endothelial cells: new insights into cell therapy for pulmonary arterial hypertension.Q54738924
Differential proteomic analysis of human glioblastoma and neural stem cells reveals HDGF as a novel angiogenic secreted factor.Q55462273
Akt takes center stage in angiogenesis signalingQ73333632
Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferationQ73441800
The aortic ring model of angiogenesisQ81931174
PI3K/AKT/mTOR Pathway in AngiogenesisQ21129332
Concise review: Circulating endothelial progenitor cells for vascular medicineQ27022889
Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell culturesQ33385959
Novel cell-free strategy for therapeutic angiogenesis: in vitro generated conditioned medium can replace progenitor cell transplantationQ33455791
Endothelial progenitor cells induce a phenotype shift in differentiated endothelial cells towards PDGF/PDGFRβ axis-mediated angiogenesisQ33760892
Secretome from mesenchymal stem cells induces angiogenesis via Cyr61Q33814461
Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cellsQ34145472
Mesenchymal stem cells secrete multiple cytokines that promote angiogenesis and have contrasting effects on chemotaxis and apoptosisQ34256627
Paracrine mechanisms of stem cell reparative and regenerative actions in the heartQ34494230
Angiogenic properties of human dental pulp stem cellsQ34948750
Factors secreted by endothelial progenitor cells enhance neurorepair responses after cerebral ischemia in miceQ34984321
Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brainQ35007872
Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcersQ35073067
Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularizationQ35111623
Secretome of apoptotic peripheral blood cells (APOSEC) confers cytoprotection to cardiomyocytes and inhibits tissue remodelling after acute myocardial infarction: a preclinical study.Q35587397
Functions of MAP kinases: insights from gene-targeting studiesQ35814826
Endothelial progenitor cells: characterization and role in vascular biologyQ35867837
Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use.Q36055443
Rat brain endothelial cell lines for the study of blood-brain barrier permeability and transport functionsQ36166105
Factors secreted by mesenchymal stem cells and endothelial progenitor cells have complementary effects on angiogenesis in vitroQ36587712
Extracellular ATP is a pro-angiogenic factor for pulmonary artery vasa vasorum endothelial cellsQ36784736
Factors released from embryonic stem cells inhibit apoptosis in H9c2 cells through PI3K/Akt but not ERK pathwayQ36844587
Similarities between angiogenesis and neural development: what small animal models can tell us.Q36976443
Evidence of endothelial dysfunction in the development of Alzheimer's disease: Is Alzheimer's a vascular disorder?Q37285389
Intravenous transplants of human adipose-derived stem cell protect the brain from traumatic brain injury-induced neurodegeneration and motor and cognitive impairments: cell graft biodistribution and soluble factors in young and aged ratsQ37399945
Endothelial progenitor cell-based neovascularization: implications for therapy.Q37419757
20-HETE regulates the angiogenic functions of human endothelial progenitor cells and contributes to angiogenesis in vivoQ37603893
Clinical potential of adult vascular progenitor cells.Q37746559
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
secretomeQ17042943
P304page(s)e95731
P577publication date2014-04-22
P1433published inPLOS OneQ564954
P1476titleThe secretome of endothelial progenitor cells promotes brain endothelial cell activity through PI3-kinase and MAP-kinase
P478volume9

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cites work (P2860)
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Q36537288Endothelial progenitor cells and neural progenitor cells synergistically protect cerebral endothelial cells from Hypoxia/reoxygenation-induced injury via activating the PI3K/Akt pathway
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