Shikonin Isolated from Lithospermum erythrorhizon Downregulates Proinflammatory Mediators in Lipopolysaccharide-Stimulated BV2 Microglial Cells by Suppressing Crosstalk between Reactive Oxygen Species and NF-κB.

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Shikonin Isolated from Lithospermum erythrorhizon Downregulates Proinflammatory Mediators in Lipopolysaccharide-Stimulated BV2 Microglial Cells by Suppressing Crosstalk between Reactive Oxygen Species and NF-κB. is …
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scholarly articleQ13442814

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P356DOI10.4062/BIOMOLTHER.2015.006
P932PMC publication ID4354311
P698PubMed publication ID25767678
P5875ResearchGate publication ID273463921

P2093author name stringYung Hyun Choi
Gi-Young Kim
Rajapaksha Gedara Prasad
P2860cites workCyclooxygenase-2 inhibition attenuates lipopolysaccharide-induced cardiovascular failure.Q44240436
NF-kappaB controls the global pro-inflammatory response in endothelial cells: evidence for the regulation of a pro-atherogenic programQ24815705
Anticancer agent shikonin is an incompetent inducer of cancer drug resistanceQ28484828
An oxidative stress mechanism of shikonin in human glioma cellsQ28537574
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Nitric oxide synthases: Roles, tolls, and controlsQ29618629
Sustained, neuron-specific IKK/NF-κB activation generates a selective neuroinflammatory response promoting local neurodegeneration with agingQ30557279
Microglia as mediators of inflammatory and degenerative diseasesQ33593415
The clinical potential of cyclooxygenase-2-specific inhibitorsQ33676740
Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activityQ33957447
Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activationQ34338138
Shikonin inhibits maturation of bone marrow-derived dendritic cells and suppresses allergic airway inflammation in a murine model of asthmaQ34442308
Targeting NOX, INOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicalsQ34583278
The inflammatory macrophage: a story of Jekyll and HydeQ35041589
Inhibition of lipopolysaccharide‐inducible nitric oxide synthase, TNF‐α and COX‐2 expression by sauchinone effects on I‐κBα phosphorylation, C/EBP and AP‐1 activationQ35045262
Topoisomerase I inhibitors, shikonin and topotecan, inhibit growth and induce apoptosis of glioma cells and glioma stem cellsQ35058674
NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration.Q35735669
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Therapeutic targets in prostaglandin E2 signaling for neurologic disease.Q37221356
Anti-TNF-α Agents in the Treatment of Immune-Mediated Inflammatory Diseases: Mechanisms of Action and PitfallsQ37810960
Nitric oxide in neurodegeneration: potential benefits of non-steroidal anti-inflammatoriesQ37959790
NF-κB signaling pathway and free radical impact.Q38031467
Potentiation of lipopolysaccharide-inducible cyclooxygenase 2 expression by C2-ceramide via c-Jun N-terminal kinase-mediated activation of CCAAT/enhancer binding protein beta in macrophagesQ38357227
Shikonin inhibits the proliferation of human lens epithelial cells by inducing apoptosis through ROS and caspase-dependent pathway.Q38981543
Curcumin induces the apoptotic intrinsic pathway via upregulation of reactive oxygen species and JNKs in H9c2 cardiac myoblastsQ39011838
Shikonin inhibits the lipopolysaccharide-induced release of HMGB1 in RAW264.7 cells via IFN and NF-κB signaling pathwaysQ39032335
Shikonin promotes intestinal wound healing in vitro via induction of TGF-β release in IEC-18 cells.Q39145005
Peroxiredoxin I is a ROS/p38 MAPK-dependent inducible antioxidant that regulates NF-κB-mediated iNOS induction and microglial activationQ39163550
Naturally-occurring shikonin analogues--a class of necroptotic inducers that circumvent cancer drug resistanceQ39913286
Tumor necrosis factor: a pleiotropic cytokine and therapeutic targetQ40759728
Cytokine-induced activation of nuclear factor-kappa B is inhibited by hydrogen peroxide through oxidative inactivation of IkappaB kinaseQ40789302
Shikonin Suppresses Human T Lymphocyte Activation through Inhibition of IKK β Activity and JNK PhosphorylationQ41428122
Curcumin attenuates oxidative stress following downhill running-induced muscle damage.Q43464925
Protective effect of shikonin in experimental ischemic stroke: attenuated TLR4, p-p38MAPK, NF-κB, TNF-α and MMP-9 expression, up-regulated claudin-5 expression, ameliorated BBB permeabilityQ43537285
Shikonin exerts anti-inflammatory effects in a murine model of lipopolysaccharide-induced acute lung injury by inhibiting the nuclear factor-kappaB signaling pathwayQ43732296
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P433issue2
P921main subjectNF-κBQ411114
lipopolysaccharideQ421804
reactive oxygen speciesQ424361
microgliaQ1622829
Lithospermum erythrorhizonQ15592453
P304page(s)110-118
P577publication date2015-03-01
P1433published inBiomolecules & therapeuticsQ20020559
P1476titleShikonin Isolated from Lithospermum erythrorhizon Downregulates Proinflammatory Mediators in Lipopolysaccharide-Stimulated BV2 Microglial Cells by Suppressing Crosstalk between Reactive Oxygen Species and NF-κB.
P478volume23