Incorporation of biomarker assessment in novel clinical trial designs: personalizing brain tumor treatments

scientific article

Incorporation of biomarker assessment in novel clinical trial designs: personalizing brain tumor treatments is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1007/S11912-010-0144-X
P932PMC publication ID3155285
P698PubMed publication ID21125354
P5875ResearchGate publication ID49652365

P50authorDavid A ReardonQ73570385
Evanthia GalanisQ88613246
P2093author name stringHoward Colman
Daniel Sargent
Jann Sarkaria
Susan M Chang
Wenting Wu
P2860cites workIntegrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1Q24651548
MGMT gene silencing and benefit from temozolomide in glioblastomaQ27824832
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.Q27824850
MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group Study 26951.Q27851529
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastomaQ27860910
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trialQ29547224
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesisQ29619677
Chromosomal anomalies in oligodendroglial tumors are correlated with clinical features.Q33186142
Clinical trial designs for predictive marker validation in cancer treatment trialsQ33213015
Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment [...]Q33247166
Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034.Q33407127
Assessing the clinical impact of prognostic factors: when is "statistically significant" clinically useful?Q33538461
A multigene predictor of outcome in glioblastoma.Q34132666
A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendrogliomaQ34574621
Survival following adjuvant PCV or temozolomide for anaplastic astrocytomaQ35800632
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Tumor marker utility grading system: a framework to evaluate clinical utility of tumor markersQ40923195
Statistical aspects of prognostic factor studies in oncologyQ42388377
NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomideQ43245397
Prognostic value of 1p, 19q, 9p, 10q, and EGFR-FISH analyses in recurrent oligodendrogliomasQ44768519
Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas.Q45918451
Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402.Q48493738
Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors.Q53883940
Oligodendroglial tumors: refinement of candidate regions on chromosome arm 1p and correlation of 1p/19q status with survival.Q54714055
Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas.Q55476212
Issues and barriers to development of clinically useful tumor markers: a development pathway proposalQ74296025
A prospective randomized controlled trial of tumour chemosensitivity assay directed chemotherapy versus physician's choice in patients with recurrent platinum-resistant ovarian cancerQ80808476
P433issue1
P921main subjectbrain tumorQ233309
biomarkerQ864574
P304page(s)42-49
P577publication date2011-02-01
P1433published inCurrent Oncology ReportsQ2264969
P1476titleIncorporation of biomarker assessment in novel clinical trial designs: personalizing brain tumor treatments
P478volume13