Salvianolic Acid B Inhibits ERK and p38 MAPK Signaling in TGF-β1-Stimulated Human Hepatic Stellate Cell Line (LX-2) via Distinct Pathways

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Salvianolic Acid B Inhibits ERK and p38 MAPK Signaling in TGF-β1-Stimulated Human Hepatic Stellate Cell Line (LX-2) via Distinct Pathways is …
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scholarly articleQ13442814

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P356DOI10.1155/2012/960128
P932PMC publication ID3155803
P698PubMed publication ID21860657
P5875ResearchGate publication ID51589363

P2093author name stringLieming Xu
Zhigang Lv
P2860cites workEffects of salvianolic acid-B on TGF-beta 1 stimulated hepatic stellate cell activation and its intracellular signaling.Q31118205
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Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis.Q38333252
Effect of salvianolic-acid B on inhibiting MAPK signaling induced by transforming growth factor-β1 in activated rat hepatic stellate cellsQ39685359
TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts.Q40001601
Inhibition of p38MAP kinase suppresses fibrotic reaction of retinal pigment epithelial cellsQ40415540
Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-betaQ40751238
Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cellsQ40817472
TGF-beta1 in liver fibrosis: an inducible transgenic mouse model to study liver fibrogenesisQ42470383
Differential requirement for MEK/ERK and SMAD signaling in PAI-1 and CTGF expression in response to microtubule disruptionQ43149092
Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cellsQ44489915
Inhibition of p38MAP kinase suppresses fibrogenic reaction in conjunctiva in miceQ46932433
Effect of salvianolic acid B on Smad3 expression in hepatic stellate cells.Q51032112
Transforming growth factor-beta-induced alpha-smooth muscle cell actin expression in renal proximal tubular cells is regulated by p38beta mitogen-activated protein kinase, extracellular signal-regulated protein kinase1,2 and the Smad signalling durinQ64376822
[Actions of salvianolic acid A on CCl4-poisoned liver injury and fibrosis in rats]Q77737237
Human and rat hepatic stellate cells produce stem cell factor: a possible mechanism for mast cell recruitment in liver fibrosisQ77872015
ERK contributes to the effects of Smad signaling on oxidized LDL-induced PAI-1 expression in human mesangial cellsQ79142624
Liver fibrosis: from mechanisms to treatmentQ80426407
The role of TGF-beta 1 and cytokines in the modulation of liver fibrosis by Sho-saiko-to in rat's bile duct ligated modelQ81276871
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P304page(s)960128
P577publication date2011-08-11
P1433published inEvidence-based Complementary and Alternative MedicineQ5418319
P1476titleSalvianolic Acid B Inhibits ERK and p38 MAPK Signaling in TGF-β1-Stimulated Human Hepatic Stellate Cell Line (LX-2) via Distinct Pathways
P478volume2012