Immunogold evidence that neuronal gap junctions in adult rat brain and spinal cord contain connexin-36 but not connexin-32 or connexin-43.

scientific article

Immunogold evidence that neuronal gap junctions in adult rat brain and spinal cord contain connexin-36 but not connexin-32 or connexin-43. is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2000PNAS...97.7573R
P356DOI10.1073/PNAS.97.13.7573
P932PMC publication ID16587
P698PubMed publication ID10861019
P5875ResearchGate publication ID12457738

P2093author name stringD Patel
J E Rash
J I Nagy
T Yasumura
W A Staines
C S Furman
G L Stelmack
P2860cites workConnexin30 in rodent, cat and human brain: selective expression in gray matter astrocytes, co-localization with connexin43 at gap junctions and late developmental appearanceQ28576578
Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons.Q32014727
Cloning and expression of two related connexins from the perch retina define a distinct subgroup of the connexin family.Q32020085
Gap junction-mediated communication in the developing and adult cerebral cortexQ33596509
Diversification of gap junction proteins (connexins) in the central nervous system and the concept of functional compartmentsQ33954212
Ultrastructure, histological distribution, and freeze-fracture immunocytochemistry of gap junctions in rat brain and spinal cordQ33954217
Electrotonic coupling between neurons in cat inferior oliveQ34219455
Differential expression of three gap junction proteins in developing and mature brain tissuesQ34327171
Gap junctions: new tools, new answers, new questionsQ34778703
Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cordQ36328228
Connexin 35: a gap-junctional protein expressed preferentially in the skate retinaQ36805765
Grid-mapped freeze-fracture analysis of gap junctions in gray and white matter of adult rat central nervous system, with evidence for a "panglial syncytium" that is not coupled to neuronsQ36890982
Mixed synapses discovered and mapped throughout mammalian spinal cordQ37633836
Gap junctions, electrotonic coupling, and intercellular communicationQ37892951
Morphological Correlates of Electrical and Other Interactions through Low-Resistance Pathways between Neurons of the Vertebrate Central Nervous SystemQ39828778
Gap junctions in the brain: where, what type, how many and why?Q40487674
Connections with connexins: the molecular basis of direct intercellular signalingQ41006464
Connexins, connexons, and intercellular communicationQ41114815
SDS-digested freeze-fracture replica labeling electron microscopy to study the two-dimensional distribution of integral membrane proteins and phospholipids in biomembranes: practical procedure, interpretation and applicationQ41376995
Gap junctions as electrical synapsesQ41582100
Metabolic Coupling, Ionic Coupling and Cell ContactsQ44514347
From neuro-glue ('Nervenkitt') to glia: a prologueQ47700287
The murine gap junction gene connexin36 is highly expressed in mouse retina and regulated during brain developmentQ47915230
Direct immunogold labeling of connexins and aquaporin-4 in freeze-fracture replicas of liver, brain, and spinal cord: factors limiting quantitative analysisQ48177698
Oligodendrocytes express gap junction proteins connexin32 and connexin45.Q48698685
Differential expression of connexins during neocortical development and neuronal circuit formation.Q48723916
Connexin32 in oligodendrocytes and association with myelinated fibers in mouse and rat brainQ48761472
Gap junctions in the adult cerebral cortex: regional differences in their distribution and cellular expression of connexinsQ48830706
On the organization of astrocytic gap junctions in rat brain as suggested by LM and EM immunohistochemistry of connexin43 expressionQ48833124
Gap junctional coupling and patterns of connexin expression among neonatal rat lumbar spinal motor neurons.Q51428773
Functional properties of channels formed by the neuronal gap junction protein connexin36.Q52137784
Connexins and gap junctions of astrocytes and oligodendrocytes in the CNSQ58493657
Connexin-43 in rat spinal cord: localization in astrocytes and identification of heterotypic astro-oligodendrocytic gap junctionsQ58493665
Effect of androgen on the expression of gap junction and beta-actin mRNAs in adult rat motoneuronsQ67503929
Distribution of mRNAs coding for liver and heart gap junction proteins in the rat central nervous systemQ67916393
Cell junctions and intramembrane particles of astrocytes and oligodendrocytes: a freeze-fracture studyQ70354188
Freeze-fracture replica electron microscopy combined with SDS digestion for cytochemical labeling of integral membrane proteins. Application to the immunogold labeling of intercellular junctional complexesQ70964707
Connexin 32 mRNA levels in the rat supraoptic nucleus: up-regulation prior to parturition and during lactationQ71610753
Expression of connexin43 mRNA in adult rodent brainQ73136968
Cardiovascular diseaseQ77338708
P433issue13
P407language of work or nameEnglishQ1860
P304page(s)7573-7578
P577publication date2000-06-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleImmunogold evidence that neuronal gap junctions in adult rat brain and spinal cord contain connexin-36 but not connexin-32 or connexin-43.
P478volume97

Reverse relations

cites work (P2860)
Q43880320A dominant negative mutation of neuronal connexin 36 that blocks intercellular permeability.
Q45837759A male poecillid's sexually dimorphic body plan, behavior, and nervous system
Q47287911A potential role for neuronal connexin 36 in the pathogenesis of amyotrophic lateral sclerosis.
Q35741979Abundance and ultrastructural diversity of neuronal gap junctions in the OFF and ON sublaminae of the inner plexiform layer of rat and mouse retina
Q33810718Abundance of gap junctions at glutamatergic mixed synapses in adult Mosquitofish spinal cord neurons
Q48393262Accelerated hippocampal spreading depression and enhanced locomotory activity in mice with astrocyte-directed inactivation of connexin43.
Q30381568Activity-dependent plasticity of electrical synapses: increasing evidence for its presence and functional roles in the mammalian brain.
Q36821428Acute ethanol exposure increases firing and induces oscillations in cerebellar Golgi cells of freely moving rats
Q46450931Alterations in metabolism and gap junction expression may determine the role of astrocytes as "good samaritans" or executioners.
Q50913139Altered olivocerebellar activity patterns in the connexin36 knockout mouse.
Q44312312Analysis of Cx36 knockout does not support tenet that olivary gap junctions are required for complex spike synchronization and normal motor performance.
Q54940646Analysis of the bystander effect in cone photoreceptors via a guided neural network platform.
Q53124891Are Synchronized Changes in Connexin-43 and Caveolin-3 a Bystander Effect in a Phoneutria nigriventer Venom Model of Blood-Brain Barrier Breakdown?
Q28582084Association of connexin36 and zonula occludens-1 with zonula occludens-2 and the transcription factor zonula occludens-1-associated nucleic acid-binding protein at neuronal gap junctions in rodent retina
Q40488891Association of connexin36 with zonula occludens-1 in HeLa cells, betaTC-3 cells, pancreas, and adrenal gland
Q36100187Baclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion
Q45206220Biophysical evidence that connexin-36 forms functional gap junction channels between pancreatic mouse beta-cells
Q37033797CNQX and AMPA inhibit electrical synaptic transmission: a potential interaction between electrical and glutamatergic synapses
Q44599998Carbenoxolone Blockade of Neuronal Network Activity in Culture is not Mediated by an Action on Gap Junctions
Q24669745Cell-specific expression of connexins and evidence of restricted gap junctional coupling between glial cells and between neurons
Q34391826Cellular communication and coupling within the suprachiasmatic nucleus
Q41166652Cellular expression of connexins in the rat brain: neuronal localization, effects of kainate‐induced seizures and expression in apoptotic neuronal cells
Q38671056Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats.
Q30477777Chemical synaptic activity modulates nearby electrical synapses
Q26751434Collective timekeeping among cells of the master circadian clock
Q59800520Conditioned Media From Glial Cells Promote a Neural-Like Connexin Expression in Human Adipose-Derived Mesenchymal Stem Cells
Q36419668Cone photoreceptors in bass retina use two connexins to mediate electrical coupling
Q28582333Connexin 26 and basic fibroblast growth factor are expressed primarily in the subpial and subependymal layers in adult brain parenchyma: roles in stem cell proliferation and morphological plasticity?
Q40769318Connexin 35b expression in the spinal cord of Danio rerio embryos and larvae
Q34482628Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?
Q58493649Connexin26 in adult rodent central nervous system: Demonstration at astrocytic gap junctions and colocalization with connexin30 and connexin43
Q35768258Connexin29 and connexin32 at oligodendrocyte and astrocyte gap junctions and in myelin of the mouse central nervous system
Q24670178Connexin29 expression, immunocytochemistry and freeze-fracture replica immunogold labelling (FRIL) in sciatic nerve
Q27304994Connexin36 expression in major centers of the auditory system in the CNS of mouse and rat: Evidence for neurons forming purely electrical synapses and morphologically mixed synapses
Q30573937Connexin36 identified at morphologically mixed chemical/electrical synapses on trigeminal motoneurons and at primary afferent terminals on spinal cord neurons in adult mouse and rat
Q30573487Connexin36 in gap junctions forming electrical synapses between motoneurons in sexually dimorphic motor nuclei in spinal cord of rat and mouse
Q42910272Connexin36 knockout mice display increased sensitivity to pentylenetetrazol-induced seizure-like behaviors
Q46405105Connexin36 mediates gap junctional coupling of alpha-ganglion cells in mouse retina
Q36464582Connexin36 vs. connexin32, "miniature" neuronal gap junctions, and limited electrotonic coupling in rodent suprachiasmatic nucleus.
Q44530050Connexin43 is not expressed in principal cells of mouse cortex and hippocampus
Q30499651Connexin47, connexin29 and connexin32 co-expression in oligodendrocytes and Cx47 association with zonula occludens-1 (ZO-1) in mouse brain
Q39350483Connexins and pannexins: At the junction of neuro-glial homeostasis & disease.
Q37947566Connexins: key mediators of endocrine function
Q28210913Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines
Q35643359Death of Neurons following Injury Requires Conductive Neuronal Gap Junction Channels but Not a Specific Connexin
Q48281796Deformation of network connectivity in the inferior olive of connexin 36-deficient mice is compensated by morphological and electrophysiological changes at the single neuron level.
Q42443276Dendritic projections and dye-coupling in dopaminergic neurons of the substantia nigra examined in horizontal brain slices from young rats.
Q33209036Dendrodendritic electrical synapses between mammalian retinal ganglion cells.
Q37227528Developmental changes in the morphology of mouse hypoglossal motor neurons
Q35110436Differential expression of connexins in trigeminal ganglion neurons and satellite glial cells in response to chronic or acute joint inflammation
Q42288626Direct association of connexin36 with zonula occludens-2 and zonula occludens-3.
Q48446270Dynamical working memory and timed responses: the role of reverberating loops in the olivo-cerebellar system
Q43698704Effects of estrogen and progesterone on the expression of connexin-36 mRNA in the suprachiasmatic nucleus of female rats
Q33976143Electrical coupling and neuronal synchronization in the Mammalian brain
Q34271618Electrical synapses between GABA-releasing interneurons
Q38675220Electrical synapses in mammalian CNS: Past eras, present focus and future directions
Q48671206Electrical synapses in the thalamic reticular nucleus.
Q22337387Electrical synapses: a dynamic signaling system that shapes the activity of neuronal networks
Q43715199Electrical wiring of the oscillating brain.
Q44934652Electrotonic coupling between stratum oriens interneurones in the intact in vitro mouse juvenile hippocampus.
Q44010677Electrotonic coupling in the inferior olivary nucleus revealed by simultaneous double patch recordings
Q43568103Enrichment of neuronal and glial connexins in the postsynaptic density subcellular fraction of rat brain
Q39957773Epileptogenic potential of mefloquine chemoprophylaxis: a pathogenic hypothesis
Q48494152Evidence for a role of the N-terminal domain in subcellular localization of the neuronal connexin36 (Cx36).
Q30528489Evidence for connexin36 localization at hippocampal mossy fiber terminals suggesting mixed chemical/electrical transmission by granule cells
Q34000003Experimental evidence and modeling studies support a synchronizing role for electrical coupling in the cat thalamic reticular neurons in vivo
Q46778837Expression and function of the neuronal gap junction protein connexin 36 in developing mammalian retina
Q40659258Expression of connexin 45 in the olfactory system
Q44824292Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina.
Q48100887Expression of connexins in embryonic mouse neocortical development
Q44793398Expression of gap junction connexin36 in adult rat retinal ganglion cells
Q34317291Expression pattern of lacZ reporter gene representing connexin36 in transgenic mice
Q46118305Fine structural localization of connexin‐36 immunoreactivity in mouse cerebral cortex and thalamus
Q47643765Four classes of intercellular channels between glial cells in the CNS.
Q35672548Freeze-fracture and immunogold analysis of aquaporin-4 (AQP4) square arrays, with models of AQP4 lattice assembly
Q33705599Functional alterations in gut contractility after connexin36 ablation and evidence for gap junctions forming electrical synapses between nitrergic enteric neurons
Q28346574Functional expression of the new gap junction gene connexin47 transcribed in mouse brain and spinal cord neurons
Q33783304Fundamental role of inferior olive connexin 36 in muscle coherence during tremor.
Q38403247Gap Junctions Link Regular-Spiking and Fast-Spiking Interneurons in Layer 5 Somatosensory Cortex.
Q34839934Gap junction proteins and their role in spinal cord injury
Q34278660Gap junction-mediated electrical transmission: regulatory mechanisms and plasticity
Q33237962Gap junctions among dendrites of cortical GABAergic neurons establish a dense and widespread intercolumnar network.
Q33291298Gap junctions on hippocampal mossy fiber axons demonstrated by thin-section electron microscopy and freeze fracture replica immunogold labeling.
Q81886537Glial and neuronal connexin expression patterns in the rat spinal cord during development and following injury
Q48785736Global ischemia-induced increases in the gap junctional proteins connexin 32 (Cx32) and Cx36 in hippocampus and enhanced vulnerability of Cx32 knock-out mice.
Q50668769Heterogeneous electrotonic coupling and synchronization of rhythmic bursting activity in mouse Hb9 interneurons.
Q35842812High-resolution proteomic mapping in the vertebrate central nervous system: close proximity of connexin35 to NMDA glutamate receptor clusters and co-localization of connexin36 with immunoreactivity for zonula occludens protein-1 (ZO-1)
Q35946400Hippocampal gamma-frequency oscillations: from interneurones to pyramidal cells, and back.
Q47866769Homer, Spikar, and Other Drebrin-Binding Proteins in the Brain.
Q28507586Identification and characterization of an aquaporin 1 immunoreactive amacrine-type cell of the mouse retina
Q28566575Identification of cells expressing Cx43, Cx30, Cx26, Cx32 and Cx36 in gap junctions of rat brain and spinal cord
Q30493859Identification of connexin36 in gap junctions between neurons in rodent locus coeruleus
Q31841507Immature neocortical neurons exist as extensive syncitial networks linked by dendrodendritic electrical connections
Q36720996Immunohistochemical detection of connexin36 in sympathetic preganglionic and somatic motoneurons in the adult rat.
Q42829397Improved antigen retrieval in freeze-fracture cytochemistry by evaporation of carbon as first replication layer
Q36691419In synch but not in step: Circadian clock circuits regulating plasticity in daily rhythms
Q44306992Increased electrotonic coupling in spinal motoneurons after transient botulinum neurotoxin paralysis in the neonatal rat.
Q91771366Inner retinal preservation in the photoinducible I307N rhodopsin mutant mouse, a model of autosomal dominant retinitis pigmentosa
Q35005745Interplay of chemical neurotransmitters regulates developmental increase in electrical synapses
Q36798763Localization of neurones expressing the gap junction protein Connexin45 within the adult spinal dorsal horn: a study using Cx45-eGFP reporter mice
Q35958304Mixed Electrical-Chemical Synapses in Adult Rat Hippocampus are Primarily Glutamatergic and Coupled by Connexin-36
Q37270004Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration
Q37227505Morphologically mixed chemical-electrical synapses formed by primary afferents in rodent vestibular nuclei as revealed by immunofluorescence detection of connexin36 and vesicular glutamate transporter-1.
Q39484852Mouse horizontal cells do not express connexin26 or connexin36.
Q28512837NMDA receptors regulate developmental gap junction uncoupling via CREB signaling
Q46142218Network architecture of gap junction-coupled neuronal linkage in the striatum
Q55279785Network oscillation rules imposed by species-specific electrical coupling.
Q44426865Network-based activity induced by 4-aminopyridine in rat dorsal horn in vitro is mediated by both chemical and electrical synapses
Q35653077Neuronal connexin36 association with zonula occludens-1 protein (ZO-1) in mouse brain and interaction with the first PDZ domain of ZO-1.
Q36595739Neuronal gap junction coupling is regulated by glutamate and plays critical role in cell death during neuronal injury.
Q36493857Neuronal gap junctions: expression, function, and implications for behavior
Q42524916Noradrenergic modulation of electrical coupling in GABAergic networks of the hippocampus
Q38024575Novel model for the mechanisms of glutamate-dependent excitotoxicity: role of neuronal gap junctions
Q33809613Oocyte triplet pairing for electrophysiological investigation of gap junctional coupling.
Q45140537Oscillatory activity within rat substantia gelatinosa in vitro: a role for chemical and electrical neurotransmission.
Q35017696Pallidal gap junctions-triggers of synchrony in Parkinson's disease?
Q37485123Potent block of Cx36 and Cx50 gap junction channels by mefloquine
Q34399344Progressive changes in synaptic inputs to motoneurons in adult sacral spinal cord of a mouse model of amyotrophic lateral sclerosis
Q36402052Protein kinase A mediates regulation of gap junctions containing connexin35 through a complex pathway.
Q35387097Re-evaluation of connexins associated with motoneurons in rodent spinal cord, sexually dimorphic motor nuclei and trigeminal motor nucleus
Q36358627Regulation of gap junction coupling through the neuronal connexin Cx35 by nitric oxide and cGMP.
Q36964381Regulation of neuronal connexin-36 channels by pH
Q33711465Rhythmicity without synchrony in the electrically uncoupled inferior olive.
Q40050342Role of Connexin and Pannexin containing channels in HIV infection and NeuroAIDS.
Q81078651Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue
Q34843944Role of gap junctions in CO(2) chemoreception and respiratory control
Q46520847Role of gap junctions in synchronized neuronal oscillations in the inferior olive
Q42948518Short-range functional interaction between connexin35 and neighboring chemical synapses
Q42495387Sparse pallidal connections shape synchrony in a network model of the basal ganglia.
Q60923756Spinal Shox2 interneuron interconnectivity related to function and development
Q57860869Synchronous Activity of Inhibitory Networks in Neocortex Requires Electrical Synapses Containing Connexin36
Q27023247The contribution of electrical synapses to field potential oscillations in the hippocampal formation
Q48733746The effector and scaffolding proteins AF6 and MUPP1 interact with connexin36 and localize at gap junctions that form electrical synapses in rodent brain
Q34781127The extent and strength of electrical coupling between inferior olivary neurons is heterogeneous
Q34512150The external globus pallidus: progress and perspectives
Q28585793The mouse gap junction gene connexin29 is highly expressed in sciatic nerve and regulated during brain development
Q38865914The regulation and role of neuronal gap junctions during development
Q42362833The regulation and role of neuronal gap junctions during neuronal injury
Q38837457The role of Cx36 and Cx43 in 4-aminopyridine-induced rhythmic activity in the spinal nociceptive dorsal horn: an electrophysiological study in vitro
Q59813505Two Forms of Electrical Transmission Between Neurons
Q43297994Two forms of long-term depression in a polysynaptic pathway in the leech CNS: one NMDA receptor-dependent and the other cannabinoid-dependent
Q35978913UNC-4 antagonizes Wnt signaling to regulate synaptic choice in the C. elegans motor circuit
Q35615975UNC-4 represses CEH-12/HB9 to specify synaptic inputs to VA motor neurons in C. elegans
Q39561626Ultrastructural demonstration of Cx43 gap junctions in induced pluripotent stem cells from human cord blood
Q34883596Ultrastructural localization of connexins (Cx36, Cx43, Cx45), glutamate receptors and aquaporin-4 in rodent olfactory mucosa, olfactory nerve and olfactory bulb
Q30960102Ultrastructural study of gap junctions between dendrites of parvalbumin-containing GABAergic neurons in various neocortical areas of the adult rat.
Q36423270Under construction: building the macromolecular superstructure and signaling components of an electrical synapse.
Q94560734Understanding the Molecular and Cell Biological Mechanisms of Electrical Synapse Formation
Q36979276Use of calcium imaging for analysis of neuronal gap junction coupling
Q48614787Video-microscopic analysis of dye coupling in the salamander olfactory bulb
Q40788194Visual transmission deficits in mice with targeted disruption of the gap junction gene connexin36.

Search more.