Protein kinase D: a family affair

scientific article

Protein kinase D: a family affair is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/S0014-5793(03)00487-3
P698PubMed publication ID12829240

P50authorThomas SeufferleinQ39195476
Johan Van LintQ39198391
An RykxQ39200716
Line De KimpeQ39200751
P2093author name stringJackie R Vandenheede
Svetlana Mikhalap
Tibor Vantus
P2860cites workPKCnu, a new member of the protein kinase C family, composes a fourth subfamily with PKCmuQ22009498
Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32Q22254220
Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinasesQ24290476
Protein kinase D regulates the fission of cell surface destined transport carriers from the trans-Golgi networkQ24290905
The protein kinase complement of the human genomeQ24324497
Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathwayQ24337864
Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptorQ24529868
The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins.Q24537123
Spatial and temporal regulation of protein kinase D (PKD)Q24678757
Bruton's tyrosine kinase (Btk) associates with protein kinase C muQ28137886
Regulation of protein kinase D by multisite phosphorylation. Identification of phosphorylation sites by mass spectrometry and characterization by site-directed mutagenesisQ28139174
Gbetagamma-mediated regulation of Golgi organization is through the direct activation of protein kinase DQ28140180
Mechanism of activation of protein kinase D2(PKD2) by the CCK(B)/gastrin receptorQ28203785
Protein kinase D: an intracellular traffic regulator on the moveQ28215892
Protein kinase C mu (PKC mu) associates with the B cell antigen receptor complex and regulates lymphocyte signalingQ28294447
Recruitment of protein kinase D to the trans-Golgi network via the first cysteine-rich domain.Q28363076
P2X7 receptors activate protein kinase D and p42/p44 mitogen-activated protein kinase (MAPK) downstream of protein kinase CQ28583451
Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid.Q30175352
Identification and cloning of Kidins220, a novel neuronal substrate of protein kinase D.Q33918643
Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domainQ35731354
Determination of the specific substrate sequence motifs of protein kinase C isozymesQ36842048
Regulation of protein kinase Cnu by the B-cell antigen receptorQ40680201
Protein kinase D complexes with C-Jun N-terminal kinase via activation loop phosphorylation and phosphorylates the C-Jun N-terminusQ40738836
Protein kinase C (PKC)eta-mediated PKC mu activation modulates ERK and JNK signal pathwaysQ40763883
Rapid protein kinase D translocation in response to G protein-coupled receptor activation. Dependence on protein kinase C.Q40798554
Activation loop Ser744 and Ser748 in protein kinase D are transphosphorylated in vivo.Q40798561
Protein kinase D (PKD): a novel target for diacylglycerol and phorbol estersQ40933310
Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymesQ41173469
Oxidative stress induces protein kinase D activation in intact cells. Involvement of Src and dependence on protein kinase C.Q41728142
Mechanism of activation and function of protein kinase B.Q41732739
Co-transfection with protein kinase D confers phorbol-ester-mediated inhibition on glucagon-stimulated cAMP accumulation in COS cells transfected to overexpress glucagon receptorsQ41856369
Protein kinase D activation by mutations within its pleckstrin homology domain.Q42448861
Identification of in vivo phosphorylation sites required for protein kinase D activation.Q42462150
Protein kinase Cmu downregulation of tumor-necrosis-factor-induced apoptosis correlates with enhanced expression of nuclear-factor-kappaB-dependent protective genesQ42463364
Protein-kinase-Cmu expression correlates with enhanced keratinocyte proliferation in normal and neoplastic mouse epidermis and in cell cultureQ42467593
Protein kinase D activation by deletion of its cysteine-rich motifsQ42475083
Protein kinase D inhibits plasma membrane Na(+)/H(+) exchanger activityQ42481223
Regulated nucleocytoplasmic transport of protein kinase D in response to G protein-coupled receptor activationQ42824508
Protein kinase D potentiates DNA synthesis and cell proliferation induced by bombesin, vasopressin, or phorbol esters in Swiss 3T3 cellsQ42826316
Role of diacylglycerol in PKD recruitment to the TGN and protein transport to the plasma membraneQ43812838
Protein kinase C phosphorylates protein kinase D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain.Q44198663
CCK2 (CCK(B)/gastrin) receptor mediates rapid protein kinase D (PKD) activation through a protein kinase C-dependent pathwayQ46279700
Cell biology. Slick recruitment to the Golgi.Q52125289
Proteolytic cleavage and activation of protein kinase C [micro] by caspase-3 in the apoptotic response of cells to 1-beta -D-arabinofuranosylcytosine and other genotoxic agentsQ73675920
Association of protein kinase Cmu with type II phosphatidylinositol 4-kinase and type I phosphatidylinositol-4-phosphate 5-kinaseQ77172112
Dissimilar phorbol ester binding properties of the individual cysteine-rich motifs of protein kinase DQ77518950
An invasion-related complex of cortactin, paxillin and PKCmu associates with invadopodia at sites of extracellular matrix degradationQ78112212
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)81-86
P577publication date2003-07-01
P1433published inFEBS LettersQ1388051
P1476titleProtein kinase D: a family affair
P478volume546

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cites work (P2860)
Q39179630A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis
Q33539776A rapid method for characterization of protein relatedness using feature vectors
Q35824690A time frame permissive for Protein Kinase D2 activity to direct angiogenesis in mouse embryonic stem cells
Q28570951Aldosterone, through novel signaling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathy
Q33765496Angiotensin II-induced protein kinase D activates the ATF/CREB family of transcription factors and promotes StAR mRNA expression.
Q44931329Basic calcium phosphate crystals activate p44/42 MAPK signal transduction pathway via protein kinase Cmicro in human fibroblasts
Q34110344Bruton's tyrosine kinase and protein kinase C µ are required for TLR7/9-induced IKKα and IRF-1 activation and interferon-β production in conventional dendritic cells
Q50872799CXCL1 and CXCL2 Regulate NLRP3 Inflammasome Activation via G-Protein-Coupled Receptor CXCR2.
Q34066253Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter
Q35001275Characterization of a MAPK scaffolding protein logic gate in gonadotropes.
Q40292806Characterization of a novel protein kinase D: Caenorhabditis elegans DKF-1 is activated by translocation-phosphorylation and regulates movement and growth in vivo
Q24314735Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells
Q30313269Combining affinity enrichment, cross-linking with photo-amino acids, and mass spectrometry for probing protein kinase D2 interactions
Q47617811Computational design of new protein kinase D 1 (PKD1) inhibitors: homology-based active site prediction, energy-optimized pharmacophore, docking and database screening.
Q40292798Conserved domains subserve novel mechanisms and functions in DKF-1, a Caenorhabditis elegans protein kinase D.
Q36693824Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7.
Q34241833Curcumin attenuates β-catenin signaling in prostate cancer cells through activation of protein kinase D1.
Q36705529Derepression of pathological cardiac genes by members of the CaM kinase superfamily
Q39122407Different regulation of physiological and tumor angiogenesis in zebrafish by protein kinase D1 (PKD1).
Q39099598Differential 12-O-Tetradecanoylphorbol-13-acetate-induced activation of rat mammary carcinoma susceptibility Fbxo10 variant promoters via a PKC-AP1 pathway
Q36274555Dimeric PKD regulates membrane fission to form transport carriers at the TGN
Q40482280Dual phospholipase C/diacylglycerol requirement for protein kinase D1 activation in lymphocytes.
Q37563378Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation
Q37890712Emerging roles of protein kinase D1 in cancer
Q35207442Excitation‐transcription coupling in skeletal muscle: the molecular pathways of exercise
Q51160615Frequent low-level mutations of protein kinase D2 in angiolipoma.
Q92340414Genetic interactions between Protein Kinase D and Lobe mutants during eye development of Drosophila melanogaster
Q36798446Gβγ-mediated activation of protein kinase D exhibits subunit specificity and requires Gβγ-responsive phospholipase Cβ isoforms.
Q35044046HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization
Q46829126Identification of protein kinase D as a novel contraction-activated kinase linked to GLUT4-mediated glucose uptake, independent of AMPK.
Q30414963In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts
Q30594732Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons.
Q47925365Involvement of protein kinase D in uridine diphosphate-induced microglial macropinocytosis and phagocytosis
Q46003366Knockout of the predominant conventional PKC isoform, PKCalpha, in mouse skeletal muscle does not affect contraction-stimulated glucose uptake.
Q41731631Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland
Q44851101Lipid raft disruption triggers protein kinase C and Src-dependent protein kinase D activation and Kidins220 phosphorylation in neuronal cells
Q34775050Lysophosphatidylcholine activates a novel PKD2-mediated signaling pathway that controls monocyte migration
Q33752988Macrophage LRP-1 controls plaque cellularity by regulating efferocytosis and Akt activation
Q39923203Mechanistic analysis of the amplification and diversification events induced by Vav proteins in B-lymphocytes.
Q54580311Midkine prevented hypoxic injury of mouse embryonic stem cells through activation of Akt and HIF-1α via low-density lipoprotein receptor-related protein-1.
Q43078743Mitochondrial diacylglycerol initiates protein-kinase D1-mediated ROS signaling
Q36821650Molecular cloning, epigenetic regulation, and functional characterization of Prkd1 gene promoter in dopaminergic cell culture models of Parkinson's disease
Q39631841Novel PKCs activate ERK through PKD1 in MCF-7 cells
Q24810649Novel curcumin- and emodin-related compounds identified by in silico 2D/3D conformer screening induce apoptosis in tumor cells
Q33837268Oncogenic Protein Kinase D3 Regulating Networks in Invasive Breast Cancer
Q42516112Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes
Q24653394Overexpression of wild-type PKD2 leads to increased proliferation and invasion of BON endocrine cells
Q36336572PKC isozymes and diacylglycerol-regulated proteins as effectors of growth factor receptors
Q39400583PKCepsilon-PKD1 signaling complex at Z-discs plays a pivotal role in the cardiac hypertrophy induced by G-protein coupling receptor agonists
Q30524964PKD controls αvβ3 integrin recycling and tumor cell invasive migration through its substrate Rabaptin-5.
Q57194650PKD is recruited to sites of actin remodelling at the leading edge and negatively regulates cell migration
Q24298735Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2
Q34516277Phosphorylation of SET protein at Ser171 by protein kinase D2 diminishes its inhibitory effect on protein phosphatase 2A
Q36984917Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association
Q64109704Physical plasma-triggered ROS induces tumor cell death upon cleavage of HSP90 chaperone
Q21131622Plant and animal pathogen recognition receptors signal through non-RD kinases
Q30528048Principles of branch dynamics governing shape characteristics of cerebellar Purkinje cell dendrites
Q39752332Properties, regulation, and in vivo functions of a novel protein kinase D: Caenorhabditis elegans DKF-2 links diacylglycerol second messenger to the regulation of stress responses and life span
Q44871898Protective effect of Gö6976, a PKD inhibitor, on LPS/D: -GalN-induced acute liver injury in mice.
Q57372505Protein Kinase D Intracellular Localization and Activity Control Kinase D-interacting Substrate of 220-kDa Traffic through a Postsynaptic Density-95/Discs Large/Zonula Occludens-1-binding Motif
Q39188751Protein Kinase D family kinases: roads start to segregate
Q26747243Protein Kinase D1 Signaling in Angiogenic Gene Expression and VEGF-Mediated Angiogenesis
Q30316004Protein Kinase D2 Assembles a Multiprotein Complex at the Trans-Golgi Network to Regulate Matrix Metalloproteinase Secretion
Q34313539Protein Kinase D–mediated Phosphorylation of Polycystin-2 (TRPP2) Is Essential for Its Effects on Cell Growth and Calcium Channel Activity
Q33624522Protein Kinases C-Mediated Regulations of Drug Transporter Activity, Localization and Expression
Q35849920Protein kinase C and beyond
Q35764273Protein kinase C isozymes and addiction
Q34761380Protein kinase C isozymes as regulators of sensitivity to and self-administration of drugs of abuse-studies with genetically modified mice.
Q42834807Protein kinase C-independent activation of protein kinase D is involved in BMP-2-induced activation of stress mitogen-activated protein kinases JNK and p38 and osteoblastic cell differentiation
Q37011824Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling
Q24338510Protein kinase D 3 is localized in vesicular structures and interacts with vesicle-associated membrane protein 2
Q40131186Protein kinase D at the Golgi controls NLRP3 inflammasome activation.
Q24310379Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons
Q24299665Protein kinase D in vascular biology and angiogenesis
Q28505832Protein kinase D is implicated in the reversible commitment to differentiation in primary cultures of mouse keratinocytes
Q37036685Protein kinase D protects against oxidative stress-induced intestinal epithelial cell injury via Rho/ROK/PKC-delta pathway activation
Q24301421Protein kinase D regulates RhoA activity via rhotekin phosphorylation
Q33288881Protein kinase D regulates several aspects of development in Drosophila melanogaster.
Q28267260Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex
Q39348454Protein kinase D signaling in cancer: A friend or foe?
Q28300399Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation
Q39879745Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion
Q36711254Protein kinase D1 stimulates MEF2 activity in skeletal muscle and enhances muscle performance
Q44040143Protein kinase D2 and heat shock protein 90 beta are required for BCL6-associated zinc finger protein mRNA stabilization induced by vascular endothelial growth factor-A.
Q36905652Protein kinase D2 contributes to TNF-α-induced epithelial mesenchymal transition and invasion via the PI3K/GSK-3β/β-catenin pathway in hepatocellular carcinoma
Q30317589Protein kinase D2 induces invasion of pancreatic cancer cells by regulating matrix metalloproteinases
Q42110411Protein kinase D2 is a novel regulator of glioblastoma growth and tumor formation.
Q33813287Protein kinase D2 is an essential regulator of murine myoblast differentiation
Q47273020Protein kinase D2: a versatile player in cancer biology
Q37110417Protein kinase d regulates trafficking of dendritic membrane proteins in developing neurons.
Q39459192Proteinase-activated receptors 1 and 2 regulate invasive behavior of human melanoma cells via activation of protein kinase D1.
Q89599165Regulation of Osteoclast Differentiation at Multiple Stages by Protein Kinase D Family Kinases
Q36877300Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap1 effector molecules
Q24625904Regulation of oxysterol-binding protein Golgi localization through protein kinase D-mediated phosphorylation
Q42482584Regulation of protein kinase D during differentiation and proliferation of primary mouse keratinocytes
Q24682866Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein
Q35070394Regulation of type II PIP kinase by PKD phosphorylation
Q28476635Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans
Q24530618Role of the regulatory domain of protein kinase D2 in phorbol ester binding, catalytic activity, and nucleocytoplasmic shuttling
Q33721139Role of the second cysteine-rich domain and Pro275 in protein kinase D2 interaction with ADP-ribosylation factor 1, trans-Golgi network recruitment, and protein transport
Q35312534Spatiotemporally distinct protein kinase D activation in adult cardiomyocytes in response to phenylephrine and endothelin
Q80600442Specific PKC isoforms regulate blastocoel formation during mouse preimplantation development
Q48156182Sphingolipid metabolic flow controls phosphoinositide turnover at the trans-Golgi network
Q34648944T-cell receptor signaling to integrins
Q38723124The Involvement of Protein Kinase D in T Cell-Induced Mast Cell Activation
Q34548942The Involvement of Specific PKC Isoenzymes in Phorbol Ester-Mediated Regulation of Steroidogenic Acute Regulatory Protein Expression and Steroid Synthesis in Mouse Leydig Cells
Q53605118The activation loop phosphorylation of protein kinase D is an early marker of neuronal DNA damage.
Q24306098The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression
Q37433460The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity
Q40559835The role of protein kinase D in neurotensin secretion mediated by protein kinase C-alpha/-delta and Rho/Rho kinase.
Q46138455Transient dynamic actin cytoskeletal change stimulates the osteoblastic differentiation.
Q24336073Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase
Q36168226Wealth of opportunity - the C1 domain as a target for drug development
Q92241890[Role of protein kinase D1 in regulating the growth, apoptosis and drug sensitivity of oral squamous carcinoma cells]

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