Novel simvastatin inhalation formulation and characterisation

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Novel simvastatin inhalation formulation and characterisation is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1020128741
P356DOI10.1208/S12249-014-0127-6
P932PMC publication ID4113616
P698PubMed publication ID24806822
P5875ResearchGate publication ID264543242

P50authorHui Xin OngQ39187180
Daniela TrainiQ39187198
P2093author name stringPaul M Young
Paolo Colombo
Alaa S Tulbah
P2860cites workStatins as potential therapeutic drug for asthma?Q26864029
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Simvastatin reduces endotoxin-induced acute lung injury by decreasing neutrophil recruitment and radical formationQ34305806
Multiple dosing of simvastatin inhibits airway mucus production of epithelial cells: implications in the treatment of chronic obstructive airway pathologies.Q34615434
Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury.Q34840907
Statins as anti-inflammatory agentsQ34942903
The effect of ethanol on the formation and physico-chemical properties of particles generated from budesonide solution-based pressurized metered-dose inhalersQ35006621
Do statins improve outcomes in patients with asthma on inhaled corticosteroid therapy? A retrospective cohort analysisQ35999292
Statins and sepsis: multiple modifications at multiple levels.Q36797719
Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteersQ37225099
Chronic obstructive pulmonary disease: patho-physiology, current methods of treatment and the potential for simvastatin in disease managementQ37880077
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Aerodynamic particle size analysis of aerosols from pressurized metered-dose inhalers: comparison of Andersen 8-stage cascade impactor, next generation pharmaceutical impactor, and model 3321 Aerodynamic Particle Sizer aerosol spectrometerQ42564072
Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenaseQ42870324
Simvastatin has anti-inflammatory and antiatherosclerotic activities independent of plasma cholesterol loweringQ43516483
Simvastatin lowers C-reactive protein within 14 days: an effect independent of low-density lipoprotein cholesterol reductionQ44138516
Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary diseaseQ44358876
Balancing ethanol cosolvent concentration with product performance in 134a-based pressurized metered dose inhalersQ44489473
Statin therapy does not improve lung function in asthma: a meta-analysis of randomized controlled trialsQ44651861
A novel anti-inflammatory role of simvastatin in a murine model of allergic asthmaQ44772777
A theoretical and experimental analysis of formulation and device parameters affecting solution MDI size distributionsQ44965513
Spray pattern analysis for metered dose inhalers I: Orifice size, particle size, and droplet motion correlationsQ47319458
Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) Investigators.Q50866439
A novel apparatus for the determination of solubility in pressurized metered dose inhalers.Q51107638
Statin use is associated with reduced mortality in COPD.Q51779682
Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseQ67685401
Statins as a newly recognized type of immunomodulatorQ73252634
Modulation of aerosol clouds produced by pressurised inhalation aerosolsQ78199064
Decrease in mortality rate of chronic obstructive pulmonary disease (COPD) with statin use: a population-based analysis in JapanQ80528540
Simvastatin delivery via inhalation attenuates airway inflammation in a murine model of asthmaQ83426446
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectsimvastatinQ670131
P304page(s)956-962
P577publication date2014-05-08
P1433published inAAPS PharmSciTechQ15750612
P1476titleNovel simvastatin inhalation formulation and characterisation
P478volume15

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cites work (P2860)
Q35735440Biological Effects of Simvastatin Formulated as pMDI on Pulmonary Epithelial Cells.
Q90169812CAV1 - GLUT3 signaling is important for cellular energy and can be targeted by Atorvastatin in Non-Small Cell Lung Cancer
Q52716104Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation.
Q47755402Inhaled simvastatin nanoparticles for inflammatory lung disease
Q52633072Innovations in asthma therapy: is there a role for inhaled statins?
Q42530785Intratracheal instillation of pravastatin for the treatment of murine allergic asthma: a lung-targeted approach to deliver statins
Q36044812Simvastatin Inhibits IL-5-Induced Chemotaxis and CCR3 Expression of HL-60-Derived and Human Primary Eosinophils
Q93169465Simvastatin Nanoparticles Reduce Inflammation in LPS-Stimulated Alveolar Macrophages

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