High-throughput screen of natural product libraries for hsp90 inhibitors

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High-throughput screen of natural product libraries for hsp90 inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/BIOLOGY3010101
P932PMC publication ID4009755
P698PubMed publication ID24833337
P5875ResearchGate publication ID262381772

P50authorBrian BlaggQ87691385
P2093author name stringLakshmi Galam
Robert L Matts
Jessica Hall
Jason Davenport
Antwan Girgis
Maurie Balch
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Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticalsQ24631327
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The selectivity of protein kinase inhibitors: a further updateQ24654622
Bronchodilator and anti-inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytesQ24672043
Quality control and fate determination of Hsp90 client proteinsQ26853052
Rottlerin and cancer: novel evidence and mechanismsQ27000504
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycinQ27766755
TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90Q28203709
The Chinese hamster FANCG/XRCC9 mutant NM3 fails to express the monoubiquitinated form of the FANCD2 protein, is hypersensitive to a range of DNA damaging agents and exhibits a normal level of spontaneous sister chromatid exchangeQ28212566
The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformationQ28248831
Derrubone, an inhibitor of the Hsp90 protein folding machineryQ28257777
Potent inhibition of human telomerase by helenalinQ28268278
Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicolQ28274103
Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycinQ28277057
Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cellsQ28281956
Antimicrobial activity of flavonoidsQ28284831
Inhibition of human immunodeficiency viral replication by tannins and related compoundsQ28316974
Herbimycin, a new antibiotic produced by a strain of StreptomycesQ28327610
Two antimicrobial alkaloids from heartwood of Liriodendron tulipifera LQ28329651
Biological properties of streptonigrin derivatives. II. Inhibition of reverse transcriptase activityQ28336759
Comparative study on biological activities of heterocyclic quinones and streptonigrinQ28338153
Antiviral effect of flavonoids on the dengue virusQ28370884
Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replicationQ28378673
Identification of cytotoxic drugs that selectively target tumor cells with MYC overexpressionQ28478132
Degradation of HIF-1alpha under hypoxia combined with induction of Hsp90 polyubiquitination in cancer cells by hypericin: a unique cancer therapyQ28740279
New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassaysQ29615588
Heat shock protein inhibitors for the treatment of fungal infectionsQ37824716
Mechanisms of chemical carcinogenicity and mutagenicity: a review with implications for predictive toxicologyQ37832235
Anti-inflammatory activity of alkaloids: an update from 2000 to 2010.Q37944438
Broad action of Hsp90 as a host chaperone required for viral replicationQ37966479
Vitamin D in the new millennium.Q37976316
Curcumin--from molecule to biological function.Q38008248
Autophagy induced by farnesyltransferase inhibitors in cancer cellsQ39943626
Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activitiesQ39966800
A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cellsQ40024013
Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1.Q40116823
Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expressionQ40214504
The bioreduction of a series of benzoquinone ansamycins by NAD(P)H:quinone oxidoreductase 1 to more potent heat shock protein 90 inhibitors, the hydroquinone ansamycinsQ40258093
Pamidronate and 1,24(S)-dihydroxyvitamin D2 synergistically inhibit the growth of myeloma, breast and prostate cancer cells.Q40374263
Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancerQ40411474
Scalaradial inhibition of epidermal growth factor receptor-mediated Akt phosphorylation is independent of secretory phospholipase A2.Q40415750
Benzoquinoid ansamycins (herbimycin A and geldanamycin) interfere with the maturation of growth factor receptor tyrosine kinasesQ40425021
Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies.Q40450112
Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells.Q40469958
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitorsQ40631570
Inhibitory effects of lapachol derivatives on epstein-barr virus activationQ40676151
Dynamic activation of endothelial nitric oxide synthase by Hsp90.Q41044129
Role of NAD(P)H:quinone oxidoreductase (DT-diaphorase) in cytotoxicity and induction of DNA damage by streptonigrinQ41217766
Thaliporphine selectively inhibits expression of the inducible, but not the constitutive, nitric oxide synthaseQ41440809
Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibitionQ41631356
Anti-cancer effects of xanthones from pericarps of mangosteenQ41765214
Anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation of p53 signalingQ41972332
Chemoprevention of 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis by the dietary flavonoids chalcone, 2-hydroxychalcone, and quercetinQ42526345
Antipoliovirus structure-activity relationships of some aporphine alkaloidsQ42542551
Antifungal and antibacterial chalcones from Myrica serrata.Q42555216
Comparison of antibacterial and antifungal activities of lapachol and beta-lapachone.Q42563308
Herpes simplex virus type 1 DNA polymerase requires the mammalian chaperone hsp90 for proper localization to the nucleusQ42564096
Preclinical genotoxicology of nor-β-lapachone in human cultured lymphocytes and Chinese hamster lung fibroblastsQ42727848
Dimethyl cardamonin inhibits lipopolysaccharide-induced inflammatory factors through blocking NF-kappaB p65 activationQ42977930
The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibitionQ43206023
Inhibitors from rhubarb on lipopolysaccharide-induced nitric oxide production in macrophages: structural requirements of stilbenes for the activityQ43653190
Geldanamycin leads to superoxide formation by enzymatic and non-enzymatic redox cycling. Implications for studies of Hsp90 and endothelial cell nitric-oxide synthaseQ43976251
Antineoplastic agents 32. The pseudoguaianolide helenalinQ44331270
Sulfemodin 8-O-beta-D-glucoside, a new sulfated anthraquinone glycoside, and antioxidant phenolic compounds from Rheum emodiQ44558444
Phenolic metabolites of Dalea versicolor that enhance antibiotic activity against model pathogenic bacteriaQ44813822
Effect of chemopreventive agents on glutathione S-transferase P1-1 gene expression mechanisms via activating protein 1 and nuclear factor kappaB inhibitionQ45019943
Screening of agents which convert 'transformed morphology' of Rous sarcoma virus-infected rat kidney cells to 'normal morphology': identification of an active agent as herbimycin and its inhibition of intracellular src kinaseQ45828501
Toll-like receptor-mediated anti-inflammatory action of glaucine and oxoglaucine.Q45990045
Molecular basis for the aromatization reaction and exemestane-mediated irreversible inhibition of human aromataseQ46206523
Peganine hydrochloride dihydrate an orally active antileishmanial agentQ46337041
In vivo antitumor activity by 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone in a solid human carcinoma xenograft modelQ46418495
Modulation of arachidonic acid metabolism and nitric oxide synthesis by garcinol and its derivativesQ46644246
Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae).Q46969124
Antimicrobial activity of flavonoids from leaves of Tagetes minutaQ47792310
A non-toxic Hsp90 inhibitor protects neurons from Abeta-induced toxicityQ48286007
Natural products as sources of new drugs over the 30 years from 1981 to 2010Q29616640
Potent in vitro anticancer activity of metacycloprodigiosin and undecylprodigiosin from a sponge-derived actinomycete Saccharopolyspora sp. nov.Q31028490
Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cellsQ31039889
Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophagesQ31726526
A phase II study of insulin-like growth factor receptor inhibition with nordihydroguaiaretic acid in men with non-metastatic hormone-sensitive prostate cancerQ33160523
Induction of apoptosis in K562 human leukemia cells by 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalconeQ33217920
Investigation of the incidence of "undesirable" molecular moieties for high-throughput screening compound libraries in marketed drug compoundsQ33359104
Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffoldQ33394883
Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanismsQ33490869
Assays for identification of Hsp90 inhibitors and biochemical methods for discriminating their mechanism of actionQ33512997
Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspectiveQ33536938
Garcinol potentiates TRAIL-induced apoptosis through modulation of death receptors and antiapoptotic proteinsQ33780727
The cellular chaperone heat shock protein 90 facilitates Flock House virus RNA replication in Drosophila cellsQ33788928
Identification and initial SAR of silybin: an Hsp90 inhibitorQ33805758
Gambogic acid, a natural product inhibitor of Hsp90Q33870322
Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 ratsQ33904096
Proliferation-attenuating and apoptosis-inducing effects of tryptanthrin on human chronic myeloid leukemia K562 cell line in vitroQ33957826
What made sesquiterpene lactones reach cancer clinical trials?Q34120318
Antimicrobial activity of sesquiterpene lactones isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm.Q34187648
Targeting the molecular chaperone heat shock protein 90 (HSP90): lessons learned and future directionsQ34314706
Hsp90: chaperoning signal transductionQ34319594
NF-κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell deathQ34333336
Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera LQ34441633
A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repairQ34472013
Luteolin induces carcinoma cell apoptosis through binding Hsp90 to suppress constitutive activation of STAT3.Q34474233
The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinaseQ34517140
Antimycobacterial activity of two natural alkaloids, vasicine acetate and 2-acetyl benzylamine, isolated from Indian shrub Adhatoda vasica Ness. leavesQ34626745
The role of chalcones in suppression of NF-κB-mediated inflammation and cancerQ34682265
Cellular pharmacology studies of shikonin derivatives.Q34774883
Cancer therapy with beta-lapachoneQ34790682
Antileishmanial activity mediated by apoptosis and structure-based target study of peganine hydrochloride dihydrate: an approach for rational drug designQ34807103
Effects of α-mangostin on apoptosis induction of human colon cancerQ34884581
Chemistry and biology of roseophilin and the prodigiosin alkaloids: a survey of the last 2500 yearsQ35198509
Theaflavin Inhibits LPS-Induced IL-6, MCP-1, and ICAM-1 Expression in Bone Marrow-Derived Macrophages Through the Blockade of NF-κB and MAPK Signaling PathwaysQ35546228
Hsp90 molecular chaperone inhibitors: are we there yet?Q35655105
How retinoids regulate breast cancer cell proliferation and apoptosisQ35805457
Sesquiterpene lactones isolated from Elephantopus scaber L. inhibits human lymphocyte proliferation and the growth of tumour cell lines and induces apoptosis in vitroQ35829819
High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferaseQ35868766
Quinone reductases multitasking in the metabolic worldQ35956182
A systematic protocol for the characterization of Hsp90 modulators.Q36201554
Retinoic acid and retinoid receptors: potential chemopreventive and therapeutic role in cervical cancerQ36243762
Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cellsQ36377229
Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signalingQ36390602
Modulation of Hsp90 function in neurodegenerative disorders: a molecular-targeted therapy against disease-causing proteinQ36495265
Similar effect of rifampin and other rifamycin derivatives on vaccinia virus morphogenesisQ36581755
Natural products as a rich source of tau-targeting drugs for Alzheimer's diseaseQ36617889
Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosisQ36666275
Hsp90: a novel target for the disruption of multiple signaling cascadesQ36989967
Endothelial nitric oxide (NO) and its pathophysiologic regulationQ36992714
Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90.Q37087739
The impact of natural products upon modern drug discovery.Q37142509
Berberine Reduces the Metastasis of Chondrosarcoma by Modulating the α v β 3 Integrin and the PKC δ , c-Src, and AP-1 Signaling PathwaysQ37148562
Structures and potential antitumor activity of sesterterpenes from the marine sponge Hyrtios communisQ37257350
Antimalarials from natureQ37418468
Inhibition of cancer invasion and metastasis by targeting the molecular chaperone heat-shock protein 90.Q37469594
Impact of natural products on developing new anti-cancer agentsQ37473373
Gossypol--a polyphenolic compound from cotton plantQ37625020
Plasmodial heat shock proteins: targets for chemotherapyQ37664895
Celastrol: Molecular targets of Thunder God VineQ37708343
Implication of heat shock protein 90 (HSP90) in tumor angiogenesis: a molecular target for anti-angiogenic therapy?Q37780767
Intracellular protozoan parasites of humans: the role of molecular chaperones in development and pathogenesisQ37800962
Natural and synthetic naphthoquinones active against Trypanosoma cruzi: an initial step towards new drugs for Chagas diseaseQ37812636
Rottlerin and curcumin: a comparative analysis.Q38023565
The therapeutic target Hsp90 and cancer hallmarksQ38037753
Quinones derived from plant secondary metabolites as anti-cancer agents.Q38038887
Antimicrobial peptides and skin: a paradigm of translational medicineQ38042296
Perspectives on medicinal properties of plumbagin and its analogsQ38051532
Overview of the therapeutic potential of piplartine (piperlongumine).Q38067223
Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cellsQ38358616
Luciferase renaturation assays of chaperones and chaperone antagonistsQ38550892
Effect of geldanamycin on the kinetics of chaperone-mediated renaturation of firefly luciferase in rabbit reticulocyte lysateQ38561318
ATP-dependent chaperoning activity of reticulocyte lysateQ38568956
Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1α in vitro and in vivoQ39097185
Antitumor effect of novel berberine derivatives in breast cancer cellsQ39100924
Induction of the endoplasmic reticulum stress and autophagy in human lung carcinoma A549 cells by anacardic acidQ39108652
15,16-Dihydrotanshinone I-induced apoptosis in human colorectal cancer cells: involvement of ATF3.Q39118217
Cytotoxicity of alkaloids isolated from Peganum harmala seedsQ39133264
Alternative Pathways of Cancer Cell Death by Rottlerin: Apoptosis versus Autophagy.Q39210293
mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo.Q39262361
Anticancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signalingQ39280354
Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosisQ39281601
Luteolin exerts anti-tumor activity through the suppression of epidermal growth factor receptor-mediated pathway in MDA-MB-231 ER-negative breast cancer cellsQ39290070
Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cellsQ39295316
In vitro anti-influenza virus and anti-inflammatory activities of theaflavin derivativesQ39361326
Purification and characterization of HSP-inducers from Eupatorium lindleyanumQ39412288
α-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growthQ39430033
Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cellsQ39506045
Helenalin bypasses Bcl-2-mediated cell death resistance by inhibiting NF-κB and promoting reactive oxygen species generationQ39525457
Eudesmanolides from Taraxacum mongolicum and their inhibitory effects on the production of nitric oxideQ39563596
Garcinol inhibits cell proliferation and promotes apoptosis in pancreatic adenocarcinoma cellsQ39565032
β-Lapachone-induced reactive oxygen species (ROS) generation mediates autophagic cell death in glioma U87 MG cellsQ39638192
Design and synthesis of Hsp90 inhibitors: exploring the SAR of Sansalvamide A derivativesQ39667620
Anti-HIV and antiplasmodial activity of original flavonoid derivatives.Q39678889
VEGF-A expression in osteoclasts is regulated by NF-kappaB induction of HIF-1alphaQ39708978
Observations on screening-based research and some concerning trends in the literatureQ39769260
Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula.Q39795716
Phloretin induces apoptosis in H-Ras MCF10A human breast tumor cells through the activation of p53 via JNK and p38 mitogen-activated protein kinase signalingQ39805389
Manumycin inhibits STAT3, telomerase activity, and growth of glioma cells by elevating intracellular reactive oxygen species generation.Q39857760
(-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitorQ39900860
Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationshipsQ39926737
Screening in vitro of natural products against blood forms of Trypanosoma cruzi.Q50548392
Biochanin-A, an isoflavon, showed anti-proliferative and anti-inflammatory activities through the inhibition of iNOS expression, p38-MAPK and ATF-2 phosphorylation and blocking NFκB nuclear translocation.Q50552051
Hsp90 is obligatory for the heme-regulated eIF-2alpha kinase to acquire and maintain an activable conformation.Q52524930
Induction of autophagy by dimethyl cardamonin is associated with proliferative arrest in human colorectal carcinoma HCT116 and LOVO cells.Q53250605
Cinchonine per os: efficient circumvention of P-glycoprotein-mediated multidrug resistance.Q54179182
Bactericidal catechins damage the lipid bilayer.Q54242705
Black tea polyphenols induce human leukemic cell cycle arrest by inhibiting Akt signaling: possible involvement of Hsp90, Wnt/β-catenin signaling and FOXO1.Q54503032
Parthenolide sensitizes hepatocellular carcinoma cells to TRAIL by inducing the expression of death receptors through inhibition of STAT3 activation.Q54603551
Quinones Derived from Plant Secondary Metabolites as Anti-cancer AgentsQ57552271
Antiviral Activity of Gliotoxin and Gliotoxin AcetateQ58969324
Suppression of tumor cell growth and mitogen response by aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphineQ68682694
In vivo efficacy of antifungal oxoaporphine alkaloids in experimental disseminated candidiasisQ68853635
Inhibition of topoisomerases by fredericamycin AQ69351039
Potentiation of halogenated pyrimidine radiosensitizers in human carcinoma cells by beta-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran- 5,6-dione), a novel DNA repair inhibitorQ69395037
Kmeriol and other aromatic constituents of Kmeria duperreanaQ69761576
Fredericamycin A a new antitumor antibiotic. II. Biological propertiesQ71043857
Antitumor activities of ellagitannins against sarcoma-180 in miceQ72896098
Chalcones and their heterocyclic analogs as potential antifungal chemotherapeutic agentsQ73628110
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectnatural productQ901227
P304page(s)101-138
P577publication date2014-02-10
P1433published inBiologyQ17509951
P1476titleHigh-throughput screen of natural product libraries for hsp90 inhibitors
P478volume3

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