Megakaryocytes differentially sort mRNAs for matrix metalloproteinases and their inhibitors into platelets: a mechanism for regulating synthetic events.

scientific article

Megakaryocytes differentially sort mRNAs for matrix metalloproteinases and their inhibitors into platelets: a mechanism for regulating synthetic events. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2010-12-324517
P932PMC publication ID3158719
P698PubMed publication ID21628401
P5875ResearchGate publication ID51180234

P50authorPaolo GreseleQ37834337
Loredana BuryQ47504113
Andrew WeyrichQ72089065
P2093author name stringNeal D Tolley
Luca Cecchetti
Noemi Michetti
P2860cites workThe composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAsQ24338478
Platelet genomics and proteomics in human health and diseaseQ24536151
Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human plateletsQ24672897
Signal-dependent translation of a regulatory protein, Bcl-3, in activated human plateletsQ24675173
Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent mannerQ28185024
Platelets release active matrix metalloproteinase-2 in vivo in humans at a site of vascular injury: lack of inhibition by aspirinQ28217638
Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular eventsQ28238975
The EJC factor eIF4AIII modulates synaptic strength and neuronal protein expressionQ28567381
Single mRNA molecules demonstrate probabilistic movement in living mammalian cellsQ30716659
Analysis of SAGE data in human platelets: features of the transcriptome in an anucleate cellQ31036312
The biogenesis of platelets from megakaryocyte proplateletsQ33369405
The platelet interior revisited: electron tomography reveals tubular alpha-granule subtypesQ33571290
Membrane-type matrix metalloproteinasesQ33586502
Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAsQ33780723
Existence of a microRNA pathway in anucleate plateletsQ34025954
Megakaryocytes and beyond: the birth of plateletsQ34215516
Selective sorting of alpha-granule proteinsQ34415721
Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate plateletsQ34442383
mRNA localization: gene expression in the spatial dimensionQ34951203
Expression of matrix metalloproteinase-9 in human platelets: regulation of platelet activation in in vitro and in vivo studiesQ35047618
mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets.Q35642870
Change in protein phenotype without a nucleus: translational control in plateletsQ35881295
Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets.Q36228070
Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytesQ36313419
Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell diseaseQ36428347
Mechanics of proplatelet elaborationQ36884299
Signal-dependent protein synthesis by activated platelets: new pathways to altered phenotype and function.Q36996283
Potentiation and priming of platelet activation: a potential target for antiplatelet therapyQ37186204
PAF-acetylhydrolase expressed during megakaryocyte differentiation inactivates PAF-like lipids.Q37262394
Activated platelets signal chemokine synthesis by human monocytesQ37353355
Loss of matrix metalloproteinase 2 in platelets reduces arterial thrombosis in vivo.Q37402384
Notch signaling specifies megakaryocyte development from hematopoietic stem cells.Q37673550
De novo protein synthesis in mature platelets: a consideration for transfusion medicineQ37719648
Integrins regulate the intracellular distribution of eukaryotic initiation factor 4E in platelets. A checkpoint for translational control.Q38299411
Transcript profiling of human platelets using microarray and serial analysis of gene expressionQ38360981
Integration of proteomics and genomics in platelets: a profile of platelet proteins and platelet-specific genesQ38522436
Tissue inhibitors of matrix metalloproteinases in platelets and megakaryocytes: a novel organization for these secreted proteins.Q39857738
Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1.Q40347909
Role of tissue inhibitor of metalloproteinases-2 (TIMP-2) in regulation of pro-gelatinase A activation catalyzed by membrane-type matrix metalloproteinase-1 (MT1-MMP) in human cancer cellsQ41020537
Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand siteQ42177034
Establishment of a novel human megakaryoblastic leukemia cell line, MEG-01, with positive Philadelphia chromosomeQ42819189
Suppression of 15-lipoxygenase synthesis by hnRNP E1 is dependent on repetitive nature of LOX mRNA 3'-UTR control element DICE.Q43876606
Exogenous tissue inhibitor of metalloproteinase-1 promotes endothelial cell survival through activation of the phosphatidylinositol 3-kinase/Akt pathwayQ45230744
Intraplatelet signaling mechanisms of the priming effect of matrix metalloproteinase-2 on platelet aggregationQ46767662
Ribosome association contributes to restricting mRNAs to the cell body of hippocampal neuronsQ48305610
Platelets release matrix metalloproteinase-2 in the coronary circulation of patients with acute coronary syndromes: possible role in sustained platelet activation.Q53292318
Differential regulation of platelet aggregation by matrix metalloproteinases-9 and -2.Q54067475
Platelet transcriptional profile and protein expression in patients with systemic lupus erythematosus: up-regulation of the type I interferon system is strongly associated with vascular disease.Q54424737
Platelet release of trimolecular complex components MT1-MMP/TIMP2/MMP2: involvement in MMP2 activation and platelet aggregation.Q54790635
Dynamic Visualization of Thrombopoiesis Within Bone MarrowQ58450371
Release of gelatinase A during platelet activation mediates aggregationQ59064159
Activation of the precursor of gelatinase A/72 kDa type IV collagenase/MMP-2 in lung carcinomas correlates with the expression of membrane-type matrix metalloproteinase (MT-MMP) and with lymph node metastasisQ71820200
Outside-in signals delivered by matrix metalloproteinase-1 regulate platelet functionQ74211074
Differential regulation of matrix metalloproteinase-9 by monocytes adherent to collagen and plateletsQ74515086
Translation of glycoprotein IIIa in stored blood plateletsQ80832006
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectRNA sequencingQ2542347
P304page(s)1903-1911
P577publication date2011-05-31
P1433published inBloodQ885070
P1476titleMegakaryocytes differentially sort mRNAs for matrix metalloproteinases and their inhibitors into platelets: a mechanism for regulating synthetic events
P478volume118

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cites work (P2860)
Q84630706Alteration of the platelet transcriptome in chronic kidney disease
Q38262961Antithrombotic therapy: new areas to understand efficacy and bleeding
Q98726775Blood platelet RNA enables the detection of multiple sclerosis
Q48954046Blood platelets contain tumor-derived RNA biomarkers
Q35676042Characterization of the cytokine profile of platelet rich plasma (PRP) and PRP-induced cell proliferation and migration: Upregulation of matrix metalloproteinase-1 and -9 in HaCaT cells
Q36700678Circular RNA enrichment in platelets is a signature of transcriptome degradation
Q54489626Differential MMP-9 activity in CD34⁺progenitor cell-derived foam cells from diabetic and normoglycemic patients.
Q52147673Dynamic regulation of plasma matrix metalloproteinases in human diabetic ketoacidosis.
Q45855083In vitro uptake of recombinant factor VIIa by megakaryocytes with subsequent production of platelets containing functionally active drug
Q35128021Investigation of de novo unique differentially expressed genes related to evolution in exercise response during domestication in Thoroughbred race horses
Q100944049Is there a relationship between morphological and functional platelet changes and depressive disorder?
Q41099760MMP-2, MMP-9, and TIMP-4 and Response to Aspirin in Diabetic and Nondiabetic Patients with Stable Coronary Artery Disease: A Pilot Study.
Q39005279Maternal plasma TIMP-4 levels combined with clinical risk factors for the early prediction of pregnancy-induced hypertension
Q36542806Matrix metalloproteases and PAR1 activation
Q58701086Megakaryocyte Contribution to Bone Marrow Fibrosis: many Arrows in the Quiver
Q38543354MicroRNAs in platelet function and cardiovascular disease
Q38117746MicroRNAs in platelet production and activation.
Q47874989Molecular dynamics of FMRP and other RNA-binding proteins in MEG-01 differentiation: the role of mRNP complexes in non-neuronal development
Q26821976NETosis: how vital is it?
Q49922734Non-genomic effects of nuclear receptors: insights from the anucleate platelet.
Q38768161Normalization of qPCR in platelets - YWHAE a potential genericreference gene
Q39339846On the origin of matrix metalloproteinase-2 and -9 in blood platelets
Q90434536Platelet Biogenesis in the Lung Circulation
Q36004648Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm
Q39410921Platelet RNA as a circulating biomarker trove for cancer diagnostics
Q36897250Platelet mRNA: the meaning behind the message
Q43468988Platelet shedding of CD40L is regulated by matrix metalloproteinase-9 in abdominal sepsis
Q26824744Platelet signaling
Q36058568Platelets and platelet-like particles mediate intercellular RNA transfer
Q50307674Platelets as a surrogate disease model of neurodevelopmental disorders: Insights from Fragile X Syndrome
Q37081746Platelets as cellular effectors of inflammation in vascular diseases
Q55004062Platelets in Immune Response to Virus and Immunopathology of Viral Infections.
Q26739670Platelets in Pulmonary Immune Responses and Inflammatory Lung Diseases
Q28244689Proteasome function is required for platelet production
Q59281355Proteolytic processing of platelet receptors
Q45130974Rac1 regulates platelet shedding of CD40L in abdominal sepsis
Q38543301Regulation of the genetic code in megakaryocytes and platelets
Q26860307Role of microparticles in dengue virus infection and its impact on medical intervention strategies
Q33615612Slowed decay of mRNAs enhances platelet specific translation
Q90419870Sub-Cellular Localization of Metalloproteinases in Megakaryocytes
Q47725182Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets.
Q30528922T granules in human platelets function in TLR9 organization and signaling
Q52719266The Platelet Lifeline to Cancer: Challenges and Opportunities.
Q58710868The endothelial glycocalyx anchors von Willebrand factor fibers to the vascular endothelium
Q37607420The human platelet: strong transcriptome correlations among individuals associate weakly with the platelet proteome.
Q38543312The role of circulating platelet transcripts
Q40126127Thrombopoietin/TGF-β1 Loop Regulates Megakaryocyte Extracellular Matrix Component Synthesis.
Q100995148Tumor-Educated Platelet RNA for the Detection and (Pseudo)progression Monitoring of Glioblastoma
Q33575884Variance of matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) concentrations in activated, concentrated platelets from healthy male donors

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