Molecular architecture of the ErbB2 extracellular domain homodimer

scientific article

Molecular architecture of the ErbB2 extracellular domain homodimer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.2713
P932PMC publication ID4359325
P698PubMed publication ID25633808
P5875ResearchGate publication ID271591565

P50authorRao ZiheQ9030008
P2093author name stringZhiyong Lou
Wenyan Fu
Yajun Guo
Yuna Sun
Bohua Li
Sheng Hou
Weizhu Qian
Huaizu Guo
Xiaoze Wang
Shi Hu
Yanchun Meng
Weili Yang
P2860cites workIdentification of a region within the ErbB2/HER2 intracellular domain that is necessary for ligand-independent associationQ24297029
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Structure of the extracellular region of HER2 alone and in complex with the Herceptin FabQ27640593
The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptorsQ27640631
ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptorQ27657234
Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF ReceptorQ27664092
Insights into HER2 signaling from step-by-step optimization of anti-HER2 antibodiesQ27683825
Cell signaling by receptor tyrosine kinasesQ27860474
Untangling the ErbB signalling networkQ27860884
An open-and-shut case? Recent insights into the activation of EGF/ErbB receptorsQ28207289
The EGF receptor family: spearheading a merger of signaling and therapeuticsQ28289369
Ligand-induced, receptor-mediated dimerization and activation of EGF receptorQ28646134
ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancerQ28678776
Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimersQ28679173
EGF-ERBB signalling: towards the systems levelQ29619032
Epidermal growth factor receptor: mechanisms of activation and signalling.Q34185055
Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systemsQ34292599
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complexQ34314489
The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factorsQ36334739
Neu differentiation factor activation of ErbB-3 and ErbB-4 is cell specific and displays a differential requirement for ErbB-2.Q36556065
The kinase domain and membrane localization determine intracellular interactions between epidermal growth factor receptorsQ38298693
All EGF(ErbB) receptors have preformed homo- and heterodimeric structures in living cells.Q39941394
Flow cytometric FRET analysis of erbB receptor interaction on a cell-by-cell basisQ39966019
Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signalingQ40015717
ErbB3/HER3 does not homodimerize upon neuregulin binding at the cell surfaceQ40540606
The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactionsQ41554100
Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growthQ44120544
A novel proximity assay for the detection of proteins and protein complexes: quantitation of HER1 and HER2 total protein expression and homodimerization in formalin-fixed, paraffin-embedded cell lines and breast cancer tissue.Q51824154
HER2/Neu: mechanisms of dimerization/oligomerizationQ77628599
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)1695-1706
P577publication date2015-01-01
P1433published inOncotargetQ1573155
P1476titleMolecular architecture of the ErbB2 extracellular domain homodimer
P478volume6

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cites work (P2860)
Q36314931A computational analysis of in vivo VEGFR activation by multiple co-expressed ligands.
Q92890062A germline alteration of ERBB2 increases the risk of breast cancer in Chinese Han women with a familial history of malignant tumors
Q36114109An anti-ErbB2 fully human antibody circumvents trastuzumab resistance
Q38703210Combating acquired resistance to trastuzumab by an anti-ErbB2 fully human antibody
Q37709032Heregulin-expressing HER2-positive breast and gastric cancer exhibited heterogeneous susceptibility to the anti-HER2 agents lapatinib, trastuzumab and T-DM1.
Q55000376Inhibition of HER3 activation and tumor growth with a human antibody binding to a conserved epitope formed by domain III and IV.
Q38695293Liquid-phase electron microscopy of molecular drug response in breast cancer cells reveals irresponsive cell subpopulations related to lack of HER2 homodimers
Q57105786Mechanisms Underlying the Action and Synergism of Trastuzumab and Pertuzumab in Targeting HER2-Positive Breast Cancer
Q33364587Pertuzumab and breast cancer: another piece in the anti-HER2 puzzle
Q38573858Pharmacokinetics, pharmacodynamics and clinical efficacy of pertuzumab in breast cancer therapy
Q40975738Protein lysine methyltransferase SMYD3 is involved in tumorigenesis through regulation of HER2 homodimerization.
Q64084185The Effects of Pertuzumab and Its Combination with Trastuzumab on HER2 Homodimerization and Phosphorylation
Q92908478Visualisation of HER2 homodimers in single cells from HER2 overexpressing primary formalin fixed paraffin embedded tumour tissue

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