Apolipoprotein E4 exaggerates diabetic dyslipidemia and atherosclerosis in mice lacking the LDL receptor.

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Apolipoprotein E4 exaggerates diabetic dyslipidemia and atherosclerosis in mice lacking the LDL receptor. is …
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scholarly articleQ13442814

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P356DOI10.2337/DB11-0466
P932PMC publication ID3161311
P698PubMed publication ID21810592
P5875ResearchGate publication ID51541591

P50authorLance JohnsonQ79714953
Jose M Arbones-MainarQ39940670
P2093author name stringRaymond G Fox
Hyung-Suk Kim
Nobuyo Maeda
Avani A Pendse
Michael K Altenburg
P2860cites workA simple method for the isolation and purification of total lipides from animal tissuesQ25939009
Apolipoprotein E: far more than a lipid transport proteinQ28204471
Regulation of acetyl-CoA carboxylaseQ28302613
Apo E structure determines VLDL clearance and atherosclerosis risk in mice.Q30322098
Differential modulation of diet-induced obesity and adipocyte functionality by human apolipoprotein E3 and E4 in miceQ33585519
Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart AssociationQ33728882
The role of the LDL receptor in apolipoprotein B secretionQ33939089
Clinical review 124: Diabetic dyslipidemia: causes and consequencesQ34174659
Apolipoprotein E recycling: implications for dyslipidemia and atherosclerosisQ36350929
Genetic factors in diabetic nephropathyQ36974103
Effect of hyperglycemia and hyperlipidemia on atherosclerosis in LDL receptor-deficient mice: establishment of a combined model and association with heat shock protein 65 immunity.Q51555624
Influence of apo E phenotype on postprandial triglyceride and glucose responses in subjects with and without coronary heart disease.Q51576055
Liver carbohydrate and lipid metabolism of insulin-deficient mice is altered by trans-10, cis-12 conjugated linoleic acid.Q54725694
Association ofAPOEgenotype with carotid atherosclerosis in men and womenQ57337129
Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptorQ64382900
Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and AtherosclerosisQ73500603
ApoE epsilon2/epsilon3/epsilon4 polymorphism, ApoC-III/ApoE ratio and metabolic syndromeQ80478902
Apolipoprotein E polymorphism--a risk factor for metabolic syndromeQ81233537
Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesionsQ37486465
Lipoprotein physiology in nondiabetic and diabetic states. Relationship to atherogenesisQ37548758
Absence of hyperlipidemia in LDL receptor-deficient mice having apolipoprotein B100 without the putative receptor-binding sequencesQ37608495
Apolipoprotein E4 in macrophages enhances atherogenesis in a low density lipoprotein receptor-dependent mannerQ37612769
Very low density lipoprotein (VLDL) receptor-deficient mice have reduced lipoprotein lipase activity. Possible causes of hypertriglyceridemia and reduced body mass with VLDL receptor deficiencyQ38292966
Protection from obesity in mice lacking the VLDL receptorQ38296977
A self-contained 48-well fatty acid oxidation assayQ40565825
Apolipoprotein E: structure-function relationshipsQ40737965
ApoE isoform-dependent changes in hippocampal synaptic functionQ41519066
Fatty acid regulation of very low density lipoprotein productionQ41521188
Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in miceQ42327899
Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3.Q44582249
Obesity modulates the association among APOE genotype, insulin, and glucose in men.Q44705316
Hepatic secretion of small lipoprotein particles in apobec-1-/- mice is regulated by the LDL receptor.Q44897933
Apolipoprotein e4 allele is predictor of coronary artery disease death in elderly patients with type 2 diabetes mellitusQ44928858
Defective VLDL metabolism and severe atherosclerosis in mice expressing human apolipoprotein E isoforms but lacking the LDL receptorQ45079596
Effect of streptozotocin-induced hyperglycemia on lipid profiles, formation of advanced glycation endproducts in lesions, and extent of atherosclerosis in LDL receptor-deficient miceQ45120387
Effects of diabetes and CETP expression on diet-induced atherosclerosis in LDL receptor-deficient mice.Q45241682
Identification of apolipoprotein B-100 low density lipoproteins, apolipoprotein B-48 remnants, and apolipoprotein E-rich high density lipoproteins in the mouse.Q46035244
Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemiaQ46345830
apoE4 allele and the natural history of cardiovascular risk factorsQ46381127
Multiple pathways of apolipoprotein E signaling in primary neuronsQ46386555
Decreased lipoprotein clearance is responsible for increased cholesterol in LDL receptor knockout mice with streptozotocin-induced diabetesQ46696587
Overproduction of large VLDL particles is driven by increased liver fat content in man.Q46931621
The transport of triglycerides through the secretory pathway of hepatocytes is impaired in apolipoprotein E deficient miceQ47926062
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 3.0 UnportedQ19125045
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectatherosclerosisQ12252367
dyslipidemiaQ66291209
P1104number of pages10
P304page(s)2285-2294
P577publication date2011-08-01
P1433published inDiabetesQ895262
P1476titleApolipoprotein E4 exaggerates diabetic dyslipidemia and atherosclerosis in mice lacking the LDL receptor
P478volume60

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cites work (P2860)
Q38154771A possible structural basis behind the pathogenic role of apolipoprotein E hereditary mutations associated with lipoprotein glomerulopathy.
Q36538782Amelioration of Metabolic Syndrome-Associated Cognitive Impairments in Mice via a Reduction in Dietary Fat Content or Infusion of Non-Diabetic Plasma.
Q36843340ApoE knockout and knockin mice: the history of their contribution to the understanding of atherogenesis
Q87289574Apolipoprotein E Epsilon 4 Enhances the Association between the rs2910164 Polymorphism of miR-146a and Risk of Atherosclerotic Cerebral Infarction
Q36201919Apolipoprotein E4 impairs macrophage efferocytosis and potentiates apoptosis by accelerating endoplasmic reticulum stress
Q50035045Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response
Q34759070CNF1 increases brain energy level, counteracts neuroinflammatory markers and rescues cognitive deficits in a murine model of Alzheimer's disease
Q42830359Effects of adipocyte-secreted factors on decidualized endometrial cells: modulation of endometrial receptivity in vitro
Q37645475Expression of human apolipoprotein E4 reduces insulin-receptor substrate 1 expression and Akt phosphorylation in the ageing liver
Q57817035Hyperglycemia Aggravates Diet-Induced Coronary Artery Disease and Myocardial Infarction in SR-B1-Knockout/ApoE-Hypomorphic Mice
Q33913173Polymerase I and transcript release factor (PTRF) regulates adipocyte differentiation and determines adipose tissue expandability.
Q37489258Reduced phosphorylation of brain insulin receptor substrate and Akt proteins in apolipoprotein-E4 targeted replacement mice.
Q38176761The E. coli CNF1 as a pioneering therapy for the central nervous system diseases
Q36462050Thermodynamic and structural destabilization of apoE3 by hereditary mutations associated with the development of lipoprotein glomerulopathy
Q57476233Thermodynamic destabilization and aggregation propensity as the underlying mechanism behind the genetic association of apoE3 mutants and Lipoprotein Glomerulopathy
Q51735096γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor.

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