NOD1 activators link innate immunity to insulin resistance

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NOD1 activators link innate immunity to insulin resistance is …
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scholarly articleQ13442814

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P356DOI10.2337/DB11-0004
P8608Fatcat IDrelease_wlv4do547jgttn2pxbywss6mvu
P932PMC publication ID3161332
P698PubMed publication ID21715553
P5875ResearchGate publication ID51454131

P50authorDana PhilpottQ63991698
Amira KlipQ64974771
Adria GiaccaQ80162695
P2093author name stringZhi Liu
Jonathan D Schertzer
Gregory R Steinberg
Morgan D Fullerton
Philip J Bilan
Akhilesh K Tamrakar
Sandra Pereira
Joao G Magalhães
P2860cites workMurine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxinQ24539124
An obesity-associated gut microbiome with increased capacity for energy harvestQ27860515
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasisQ28510028
Metabolic endotoxemia initiates obesity and insulin resistanceQ29547720
Thioredoxin-interacting protein links oxidative stress to inflammasome activationQ29614471
Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5Q29615053
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in miceQ29615055
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signalingQ29616024
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistanceQ29616026
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha functionQ29616104
TLR4 links innate immunity and fatty acid-induced insulin resistanceQ29617577
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycanQ29618544
AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistanceQ33581151
Cluster analysis of insulin action in adipocytes reveals a key role for Akt at the plasma membraneQ33593816
Nutrient sensing and inflammation in metabolic diseasesQ33623354
Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in miceQ33687009
Staphylococcal peptidoglycan co-localizes with Nod2 and TLR2 and activates innate immune response via both receptors in primary murine keratinocytesQ33719311
Mechanisms of insulin resistance after insulin-induced hypoglycemia in humans: the role of lipolysisQ33869737
Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognitionQ34166263
Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.Q34333517
Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetesQ34594406
Progression from IGT to type 2 diabetes mellitus: the central role of impaired early insulin secretionQ35087584
Innate immune recognition of microbes through Nod1 and Nod2: implications for diseaseQ35781368
Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistanceQ36793492
AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle.Q52573139
T-ing up inflammation in fatQ58197131
Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusatesQ68161753
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivityQ36931760
Nod-like proteins in inflammation and disease.Q37045747
Keratinocyte-derived chemokine in obesity: expression, regulation, and role in adipose macrophage infiltration and glucose homeostasisQ37344018
The development of a metabolic disease phenotype in CTP:phosphoethanolamine cytidylyltransferase-deficient miceQ37377657
NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouseQ37391778
The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammationQ37627659
NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin ResistanceQ39647567
Palmitate- and lipopolysaccharide-activated macrophages evoke contrasting insulin responses in muscle cellsQ39931558
Differential modulation of Nods signaling pathways by fatty acids in human colonic epithelial HCT116 cellsQ40170522
Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunityQ41171975
Stimulation with Peptidoglycan induces interleukin 6 and TLR2 expression and a concomitant downregulation of expression of adiponectin receptors 1 and 2 in 3T3-L1 adipocytesQ41828178
Hepatocytes express functional NOD1 and NOD2 receptors: a role for NOD1 in hepatocyte CC and CXC chemokine productionQ42450600
Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptakeQ42828593
Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity.Q42924282
Energy intake is associated with endotoxemia in apparently healthy men.Q45769895
Nod2-dependent Th2 polarization of antigen-specific immunity.Q46239376
Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivoQ46939071
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 3.0 UnportedQ19125045
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectinsulin resistanceQ1053470
preproinsulinQ7240673
P1104number of pages10
P304page(s)2206-2215
P577publication date2011-06-29
P1433published inDiabetesQ895262
P1476titleNOD1 activators link innate immunity to insulin resistance
P478volume60

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