Beyond the dopamine receptor: regulation and roles of serine/threonine protein phosphatases

scientific article

Beyond the dopamine receptor: regulation and roles of serine/threonine protein phosphatases is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.3389/FNANA.2011.00050
P932PMC publication ID3162284
P698PubMed publication ID21904525
P5875ResearchGate publication ID51636130

P50authorPaul GreengardQ309979
Angus C. NairnQ37621746
P2093author name stringSven Ivar Walaas
Hugh Caroll Hemmings
P2860cites workPhosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neuronsQ22010952
DARPP-32 mediates the actions of multiple drugs of abuseQ22241668
DARPP-32: regulator of the efficacy of dopaminergic neurotransmissionQ23909380
Requirement for DARPP-32 in progesterone-facilitated sexual receptivity in female rats and miceQ23920781
MASTL is the human ortholog of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesisQ24298633
Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sitesQ24304144
A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiationQ24305050
Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological propertiesQ24312137
The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2AQ24317087
Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1Q24532150
Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: SchizophreniaQ24532517
Neurogenetics and pharmacology of learning, motivation, and cognitionQ24602643
Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learningQ24674131
Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognitionQ24681770
Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1Q27729832
Functional profiling of the Saccharomyces cerevisiae genomeQ27860544
Amplification of dopaminergic signaling by a positive feedback loopQ28142174
Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclinQ28202607
Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPPQ28215053
DARPP-32 expression arises after a phase of dysplasia in oesophageal squamous cell carcinomaQ36625979
ERK2: a logical AND gate critical for drug-induced plasticity?Q36644968
Differential expression of protein phosphatase 1 isoforms in mammalian brain.Q36703761
Detailed structural characterization of unbound protein phosphatase 1 inhibitorsQ37105049
Endosulfine, an endogenous peptidic ligand for the sulfonylurea receptor: purification and partial characterization from ovine brainQ37113798
Phosphorylation of Rap1GAP, a striatally enriched protein, by protein kinase A controls Rap1 activity and dendritic spine morphologyQ37117611
Darpp-32 and its truncated variant t-Darpp have antagonistic effects on breast cancer cell growth and herceptin resistanceQ37248165
Modelling of DARPP-32 regulation to understand intracellular signaling in psychiatric disease.Q37255845
Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugsQ37332784
Dopamine-sensitive adenylate cyclase in mammalian brain: a possible site of action of antipsychotic drugsQ37437347
Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophreniaQ28216472
Identification of a dopamine- and 3'5'-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid glandQ28236361
DARPP-32 and NCS-1 expression is not altered in brains of rats treated with typical or atypical antipsychoticsQ28244179
Coamplified and overexpressed genes at ERBB2 locus in gastric cancerQ28247481
Distribution of DARPP-32 in the basal ganglia: an electron microscopic studyQ28247832
Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissueQ28250285
Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase IIQ28255176
DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1Q28259380
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Regional and cellular distribution in the rat brainQ28265789
Phosphorylation of DARPP-32 at Threonine-34 is required for cocaine actionQ28269125
Dopaminergic abnormalities in select thalamic nuclei in schizophrenia: involvement of the intracellular signal integrating proteins calcyon and spinophilinQ28275161
Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse numberQ28297899
The leukocytes expressing DARPP-32 are reduced in patients with schizophrenia and bipolar disorderQ28303055
Immunohistochemical and immunoblot analysis of Dopamine and cyclic AMP-regulated phosphoprotein, relative molecular mass 32,000 (DARPP-32) in the prefrontal cortex of subjects with schizophrenia and bipolar disorderQ28303664
DARPP-32 is a robust integrator of dopamine and glutamate signalsQ28469090
A kinetic model of dopamine- and calcium-dependent striatal synaptic plasticityQ28472858
A phosphatase cascade by which rewarding stimuli control nucleosomal responseQ28508656
Nerve growth factor controls GAP-43 mRNA stability via the phosphoprotein ARPP-19Q28564744
Differential expression of ARPP-16 and ARPP-19, two highly related cAMP-regulated phosphoproteins, one of which is specifically associated with dopamine-innervated brain regionsQ28566137
Localization of alpha-endosulphine in pancreatic somatostatin delta cells and expression during rat pancreas developmentQ28581870
Regulation of DARPP-32 dephosphorylation at PKA- and Cdk5-sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase-2AQ28641016
A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regionsQ28643908
Mammalian brain phosphoproteins as substrates for calcineurinQ28643957
A translational profiling approach for the molecular characterization of CNS cell typesQ29615252
alpha-Endosulfine is a conserved protein required for oocyte meiotic maturation in DrosophilaQ30486429
Prefrontal and striatal dopaminergic genes predict individual differences in exploration and exploitationQ30498976
Quantitative analysis of protein phosphorylation in mouse brain by hypothesis-driven multistage mass spectrometryQ33229338
Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopyQ33300201
Immunohistochemical evidence for the existence of a dopamine- and cyclic AMP-regulated phosphoprotein (DARPP-32) in brown adipose tissue of pigsQ33672688
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascadeQ33703262
Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatumQ33723743
Expression of t-DARPP mediates trastuzumab resistance in breast cancer cellsQ33743601
A dopaminergic gene cluster in the prefrontal cortex predicts performance indicative of general intelligence in genetically heterogeneous miceQ33754558
Immunocytochemical localization of DARPP-32, a dopamine and cyclic-AMP-regulated phosphoprotein, in the primate brainQ48432548
Dopamine receptor signaling molecules are altered in elderly schizophrenic cortexQ48492527
Bidirectional regulation of DARPP-32 phosphorylation by dopamine.Q48617260
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Purification and characterization of the phosphoprotein from bovine caudate nucleusQ48691482
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization.Q48691508
Chronic treatment of rats with SCH-23390 or raclopride does not affect the concentrations of DARPP-32 or its mRNA in dopamine-innervated brain regionsQ48943508
Endosulfine, endogenous ligand for the sulphonylurea receptor: isolation from porcine brain and partial structural determination of the alpha formQ49149470
A quantitative study on the nigro-neostriatal dopamine neuron system in the rat.Q51232410
Characterization of the inhibition of protein phosphatase-1 by DARPP-32 and inhibitor-2.Q53556579
Backbone 1H, 15N, and 13C resonance assignments of ARPP-19Q58111951
Phosphorylation of DARPP-32, a Dopamine- and cAMP-regulated Phosphoprotein, by Casein Kinase Iin Vitroandin VivoQ58112703
Regional distribution of calcium- and cyclic adenosine 3':5'-monophosphate-regulated protein phosphorylation systems in mammalian brain. I. Particulate systemsQ58113987
Regional distribution of calcium- and cyclic adenosine 3':5'-monophosphate-regulated protein phosphorylation systems in mammalian brain. II. Soluble systemsQ58114001
Study of the conformation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by fluorescence spectroscopyQ58191998
ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Purification and characterization of the protein from bovine caudate nucleusQ69335204
ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Immunocytochemical localization in rat brainQ69335209
Inhibitors of protein phosphatase-1. Inhibitor-1 of bovine adipose tissue and a dopamine- and cAMP-regulated phosphoprotein of bovine brain are identicalQ69340296
ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Amino acid sequence of ARPP-21B from bovine caudate nucleusQ69357249
Development of a dopamine- and cyclic adenosine 3':5'-monophosphate-regulated phosphoprotein (DARPP-32) in the prenatal rat central nervous system, and its relationship to the arrival of presumptive dopaminergic innervationQ69903096
Biochemical evidence for gamma-aminobutyrate containing fibres from the nucleus accumbens to the substantia nigra and ventral tegmental area in the ratQ71167470
Cell biology. Enforcing the Greatwall in mitosisQ82920171
Altered DARPP-32 expression in the superior temporal gyrus in schizophreniaQ83756725
Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent mannerQ37448108
Protein dynamics and conformational disorder in molecular recognitionQ37544599
Looking BAC at striatal signaling: cell-specific analysis in new transgenic mice.Q37600135
Multiple receptors for dopamineQ37876912
Protein kinases in the brainQ38151210
Mechanism of inhibition of protein phosphatase 1 by DARPP-32: studies with recombinant DARPP-32 and synthetic peptidesQ38299723
Mutation analysis of DARPP-32 as a candidate gene for schizophreniaQ38312622
The effects of surgical and chemical lesions on neurotransmitter candidates in the nucleus accumbens of the rat.Q39240351
DARPP-32 binds to tra2-beta1 and influences alternative splicing.Q39751893
Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancers.Q39870542
A second heat-stable protein inhibitor of phosphorylase phosphatase from rabbit muscleQ39995361
Phosphorylation of DARPP-32 regulates breast cancer cell migration downstream of the receptor tyrosine kinase DDR1.Q40222621
The role of dopamine in modulating the structure and function of striatal circuits.Q40663529
Synthetic peptide analogs of DARPP-32 (Mr 32,000 dopamine- and cAMP-regulated phosphoprotein), an inhibitor of protein phosphatase-1. Phosphorylation, dephosphorylation, and inhibitory activityQ41201946
Histone H3 phosphorylation is under the opposite tonic control of dopamine D2 and adenosine A2A receptors in striatopallidal neurons.Q41814232
Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the basal gangliaQ42489217
The ventral striatopallidal complex: an immunocytochemical analysis of medium-sized striatal neurons and striatopallidal fibers in the basal forebrain of the rat.Q42491328
Localization of ARPP-90, a major 90 kiloDalton basal ganglion-enriched substrate for cyclic AMP-dependent protein kinase, in striatonigral neurons in the rat brainQ42492921
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein: regional, tissue, and phylogenetic distributionQ42524859
ARPP-21, a cyclic AMP-regulated phosphoprotein (Mr = 21,000) enriched in dopamine-innervated brain regions. Amino acid sequence of the site phosphorylated by cyclic AMP in intact cells and kinetic studies of its phosphorylation in vitroQ43467798
D2 dopamine receptors in striatal medium spiny neurons reduce L-type Ca2+ currents and excitability via a novel PLC[beta]1-IP3-calcineurin-signaling cascade.Q43513203
Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorderQ43645946
Increased blood pressure and loss of anp-induced natriuresis in mice lacking DARPP-32 geneQ43691195
A novel cyclin provides a link between dopamine and RNA processingQ43782611
Involvement of DARPP-32 phosphorylation in the stimulant action of caffeineQ44104351
An association study between PPP1R1B gene and schizophrenia in the Chinese populationQ44394016
Regulation of ania-6 splice variants by distinct signaling pathways in striatal neuronsQ44478504
1H, 15N, and 13C resonance assignments of DARPP-32 (dopamine and cAMP-regulated phosphoprotein, Mr. 32,000)--a protein inhibitor of protein phosphatase-1.Q44761961
A network of control mediated by regulator of calcium/calmodulin-dependent signalingQ45119454
Membrane-induced folding of the cAMP-regulated phosphoprotein endosulfine-alphaQ46052339
Reduced prefrontal cortex DARPP-32 mRNA in completed suicide victims with schizophreniaQ46523401
Expression of the MAST family of serine/threonine kinases.Q46799864
t-Darpp promotes cancer cell survival by up-regulation of Bcl2 through Akt-dependent mechanismQ46805127
Genetic analysis of the gene coding for DARPP-32 (PPP1R1B) in Japanese patients with schizophrenia or bipolar disorderQ46869417
Cocaine self-administration in mice is inversely related to phosphorylation at Thr34 (protein kinase A site) and Ser130 (kinase CK1 site) of DARPP-32.Q46981381
Ontogeny of the dopamine and cyclic adenosine-3':5'-monophosphate-regulated phosphoprotein (DARPP-32) in the pre- and postnatal mouse central nervous systemQ48160244
Fifty years of dopamine researchQ48222824
Role of calcineurin and protein phosphatase-2A in the regulation of DARPP-32 dephosphorylation in neostriatal neuronsQ48227481
DARPP-32 in the ciliary epithelium of the eye: a neurotransmitter-regulated phosphoprotein of brain localizes to secretory cellsQ48285053
Activation of the cAMP/PKA/DARPP-32 signaling pathway is required for morphine psychomotor stimulation but not for morphine rewardQ48298315
Dopamine D1 agonist SKF 38393 increases the state of phosphorylation of ARPP-21 in substantia nigraQ48324414
Quantitative immunocytochemistry of DARPP-32-expressing neurons in the rat caudatoputamenQ48364102
TARPP, a novel protein that accompanies TCR gene rearrangement and thymocyte educationQ48370565
DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Primary structure and homology with protein phosphatase inhibitor-1.Q48377963
ARPP-39, a membrane-associated substrate for cyclic AMP-dependent protein kinase present in neostriatal neuronsQ48382393
Excitatory nature of dopamine in the nigro-caudate pathwayQ48402143
Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascadesQ33762162
Localization of dopamine- and cAMP-regulated phosphoprotein-32 and inhibitor-1 in area 9 of Macaca mulatta prefrontal cortexQ33825588
Purification and cDNA cloning of ARPP-16, a cAMP-regulated phosphoprotein enriched in basal ganglia, and of a related phosphoprotein, ARPP-19.Q33910723
ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteinsQ33940666
Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac).Q34016964
DARPP-32 mediates serotonergic neurotransmission in the forebrainQ34017011
Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviorsQ34093012
Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease.Q34107415
Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulatorsQ34116108
Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosisQ34155315
t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancerQ34156895
Cholinergic interneuron characteristics and nicotinic properties in the striatumQ34159449
Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminalsQ34276042
Diverse psychotomimetics act through a common signaling pathwayQ34278280
Dopamine- and cAMP-regulated phosphoprotein (DARPP-32) and dopamine DA1 agonist-sensitive Na+,K+-ATPase in renal tubule cellsQ34313695
Alpha endosulfine is a novel molecule, structurally related to a family of phosphoproteins.Q34387162
Dopamine- and cAMP-regulated phosphoprotein DARPP-32: phosphorylation of Ser-137 by casein kinase I inhibits dephosphorylation of Thr-34 by calcineurinQ34492149
Molecular investigations of the structure and function of the protein phosphatase 1-spinophilin-inhibitor 2 heterotrimeric complexQ34579434
Dopamine: 50 years in perspectiveQ34609657
Dopamine-sensitive adenyl cyclase: possible role in synaptic transmissionQ34698478
Protein phosphatase 1 regulation by inhibitors and targeting subunitsQ34699609
WormBase 2007Q34711954
Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the "dopamine receptor".Q34721196
DARPP-32 mediates multidrug resistance of gastric cancer through regulation of P-gp and ZNRD1.Q34721823
Cocaine regulates MEF2 to control synaptic and behavioral plasticityQ34818266
Dopaminergic genes predict individual differences in susceptibility to confirmation biasQ34994120
The extended PP1 toolkit: designed to create specificityQ35092072
DARPP-32: an integrator of neurotransmissionQ35639141
Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunitQ35669844
The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A.Q35834456
Site-directed mutagenesis of amino acid residues of protein phosphatase 1 involved in catalysis and inhibitor bindingQ36101145
A mathematical tool for exploring the dynamics of biological networksQ36288480
Cloning of cDNA for DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoproteinQ36449165
Characterization of cholinergic neurons in the rat neostriatum. A combination of choline acetyltransferase immunocytochemistry, Golgi-impregnation and electron microscopy.Q36602125
P304page(s)50
P577publication date2011-08-26
P1433published inFrontiers in NeuroanatomyQ1893158
P1476titleBeyond the dopamine receptor: regulation and roles of serine/threonine protein phosphatases
P478volume5

Reverse relations

cites work (P2860)
Q41784558ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase).
Q38177261Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse.
Q36499587DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders
Q34289262Differentially co-expressed genes in postmortem prefrontal cortex of individuals with alcohol use disorders: influence on alcohol metabolism-related pathways
Q35848385Effects of protein kinase A inhibitor and activator on rewarding effects of SKF-82958 microinjected into nucleus accumbens shell of ad libitum fed and food-restricted rats
Q37519743Feedback regulation mediated by Bcl-2 and DARPP-32 regulates inositol 1,4,5-trisphosphate receptor phosphorylation and promotes cell survival
Q50312448Genetic variation in dopamine-related gene expression influences motor skill learning in mice
Q33112258Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution
Q38170011Hyperphosphorylated tau is implicated in acquired epilepsy and neuropsychiatric comorbidities
Q46169409Immunohistochemical Localization of DARPP-32 in the Brain of Two Lungfishes: Further Assessment of Its Relationship with the Dopaminergic System
Q34200391In vivo manganese exposure modulates Erk, Akt and Darpp-32 in the striatum of developing rats, and impairs their motor function
Q41412530Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses.
Q46168221Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats
Q36614190Marine Ο-3 polyunsaturated fatty acids induce sex-specific changes in reinforcer-controlled behaviour and neurotransmitter metabolism in a spontaneously hypertensive rat model of ADHD.
Q36956646Monozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin
Q35815966Motor Skill Learning Is Associated with Phase-Dependent Modifications in the Striatal cAMP/PKA/DARPP-32 Signaling Pathway in Rodents.
Q90258026Multidimensional Top-Down Proteomics of Brain-Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol
Q90428570Orphan Receptor GPR88 as an Emerging Neurotherapeutic Target
Q27310235PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis
Q48251648Phase imaging with multiple phase-cycled balanced steady-state free precession at 9.4 T.
Q39067400Potential for targeting dopamine/DARPP-32 signaling in neuropsychiatric and neurodegenerative disorders
Q24632495Protein phosphatases and Alzheimer's disease
Q35880406Protein phosphatases and their regulation in the control of mitosis
Q38700387Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition
Q41846304Selective knockout of the casein kinase 2 in d1 medium spiny neurons controls dopaminergic function
Q42111195Striatal signaling: two decades of progress.
Q58765350Sucrose Abstinence and Environmental Enrichment Effects on Mesocorticolimbic DARPP32 in Rats
Q90573731Targeting Bcl-2-IP3 receptor interaction to treat cancer: A novel approach inspired by nearly a century treating cancer with adrenal corticosteroid hormones
Q26824764The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity
Q64083779The temporal profile of activity-dependent presynaptic phospho-signalling reveals long-lasting patterns of poststimulus regulation
Q89934165Transcriptional signature of prion-induced neurotoxicity in a Drosophila model of transmissible mammalian prion disease
Q37968513Translational genetic approaches to substance use disorders: bridging the gap between mice and humans
Q58542293cAMP regulation of protein phosphatases PP1 and PP2A in brain

Search more.