Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis

scientific article

Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI76029
P932PMC publication ID4362260
P698PubMed publication ID25664849

P50authorBert W. O'MalleyQ827492
Subhamoy DasguptaQ42884402
Akash K KaushikQ86697100
P2093author name stringBin Zhang
Arul M Chinnaiyan
Erin Stashi
Jianghua Wang
Nicholas Mitsiades
Cristian Coarfa
Arun Sreekumar
Nagireddy Putluri
Kimal Rajapakshe
Michael M Ittmann
Weiwen Long
Christine A Brennan
James M Arnold
Salil K Bhowmik
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP.Q24537671
Understanding the Warburg effect: the metabolic requirements of cell proliferationQ24604760
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progressionQ24654019
Transcriptional coregulators: emerging roles of SRC family of coactivators in disease pathologyQ27030886
Human castration resistant prostate cancer rather prefer to decreased 5α-reductase activityQ39190804
Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell lineQ39998829
Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancerQ40213081
Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption.Q41779974
The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer CellsQ41859976
Lineage relationship between LNCaP and LNCaP-derived prostate cancer cell linesQ42800038
Comparison of [18 F]fluorocholine and [18 F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancerQ44018418
Glutaminolysis activates Rag-mTORC1 signaling.Q52301079
Zinc inhibition of mitochondrial aconitase and its importance in citrate metabolism of prostate epithelial cellsQ73853909
SRC-1 and TIF2 control energy balance between white and brown adipose tissuesQ78732732
Phosphoproteomic profiling of in vivo signaling in liver by the mammalian target of rapamycin complex 1 (mTORC1)Q28478869
Metabolomic profiling reveals a role for androgen in activating amino acid metabolism and methylation in prostate cancer cellsQ28479062
The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4Q28508613
SRC-2 is an essential coactivator for orchestrating metabolism and circadian rhythmQ28511887
SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolismQ28587694
Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's diseaseQ28592482
Bidirectional transport of amino acids regulates mTOR and autophagyQ29614476
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesisQ29615683
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxiaQ29616650
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addictionQ29616653
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolismQ29617213
Metabolic reprogramming: a cancer hallmark even warburg did not anticipateQ29617612
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesisQ29617613
Integrative genomic profiling of human prostate cancerQ29619905
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathwayQ30425628
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.Q33928657
Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.Q34451430
The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal musclesQ34545963
Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissuesQ34703441
Nuclear receptor coactivators: master regulators of human health and diseaseQ35082574
13C isotope-assisted methods for quantifying glutamine metabolism in cancer cellsQ35359580
Reductive carboxylation supports growth in tumour cells with defective mitochondria.Q35683311
Oncogenic activation in prostate cancer progression and metastasis: Molecular insights and future challengesQ35838821
Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.Q36517216
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipidsQ36895786
Cellular fatty acid metabolism and cancerQ37092913
Genome-wide analysis of SREBP-1 binding in mouse liver chromatin reveals a preference for promoter proximal binding to a new motif.Q37310596
Multi-modulation of nuclear receptor coactivators through posttranslational modificationsQ37329666
Transcriptional regulation of the major zinc uptake protein hZip1 in prostate cancer cellsQ37340612
Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancerQ37769360
Cancer cell metabolism: one hallmark, many faces.Q38046274
The fat side of prostate cancerQ38096735
A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growthQ38299437
Fatty acid synthase expression defines distinct molecular signatures in prostate cancer.Q38351123
In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivationQ39030433
Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.Q39149779
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectprostate cancerQ181257
P304page(s)1174-1188
P577publication date2015-02-09
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleCoactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis
P478volume125

Reverse relations

cites work (P2860)
Q47333890ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming
Q52431072Advances in functional genetic screening with transposons and CRISPR/Cas9 to illuminate cancer biology.
Q38720605Amino Acid Profiling of Zinc Resistant Prostate Cancer Cell Lines: Associations With Cancer Progression
Q38552283Androgen Receptor Coactivators in Regulation of Growth and Differentiation in Prostate Cancer
Q52558725Applications of metabolomics to study cancer metabolism.
Q47220345Coregulator profiling of the glucocorticoid receptor in lymphoid malignancies
Q37692511Corepressor metastasis-associated protein 3 modulates epithelial-to-mesenchymal transition and metastasis
Q35748982Differential Utilization of Dietary Fatty Acids in Benign and Malignant Cells of the Prostate
Q33834498From Krebs to clinic: glutamine metabolism to cancer therapy.
Q57107963Fructose and prostate cancer: toward an integrated view of cancer cell metabolism
Q47144286Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages.
Q47098821Identification of SPOP related metabolic pathways in prostate cancer
Q38734374MNX1 Is Oncogenically Upregulated in African-American Prostate Cancer
Q38662384Metabolic changes associated with tumor metastasis, part 2: Mitochondria, lipid and amino acid metabolism
Q54117923Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer.
Q28084834Metabolomic profiling of hormone-dependent cancers: a bird's eye view
Q36262595Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2).
Q34497810MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators
Q43238522Molecular Pathways: Targeting Steroid Receptor Coactivators in Cancer
Q47103669Molecular determinants of prostate cancer metastasis
Q47217714Nuclear receptors in cancer - uncovering new and evolving roles through genomic analysis.
Q41717815Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD.
Q64949570Progesterone Receptors in Prostate Cancer: Progesterone receptor B is the isoform associated with disease progression.
Q90738004Quercetin Inhibits the Proliferation and Metastasis of Human Non-Small Cell Lung Cancer Cell Line: The Key Role of Src-Mediated Fibroblast Growth Factor-Inducible 14 (Fn14)/ Nuclear Factor kappa B (NF-κB) pathway
Q64898416RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression.
Q57107504Role for Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) in Hormone-Dependent Cancers
Q57106160Role of Androgen Receptor in Prostate Cancer: A Review
Q55013403SLC2A5 promotes lung adenocarcinoma cell growth and metastasis by enhancing fructose utilization.
Q36268620SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis
Q36300613SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer
Q47692117SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology
Q38627909Taurine upregulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma
Q38820069The Role of Steroid Receptor Coactivators in Hormone Dependent Cancers and Their Potential as Therapeutic Targets
Q47379977The dark side of glucose transporters in prostate cancer: Are they a new feature to characterize carcinomas?
Q91904103UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression