Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model.

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Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/MTM.2014.32
P932PMC publication ID4362361
P698PubMed publication ID26015973
P5875ResearchGate publication ID264898814

P50authorHirokazu HiraiQ47504115
Ayumu KonnoQ50091363
Hanna GoenawanQ85049431
Fathul HudaQ85222054
P2093author name stringYasunori Matsuzaki
Koichi Miyake
Takashi Shimada
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Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8.Q35025591
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Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph diseaseQ39995612
Long-term adeno-associated viral vector-mediated expression of truncated TrkB in the adult rat facial nucleus results in motor neuron degeneration.Q40321814
Spinocerebellar ataxia type 7 cerebellar disease requires the coordinated action of mutant ataxin-7 in neurons and glia, and displays non-cell-autonomous bergmann glia degeneration.Q40329109
Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length.Q40644113
Enhanced expression of transgenes from adeno-associated virus vectors with the woodchuck hepatitis virus posttranscriptional regulatory element: implications for gene therapyQ40924169
Selective damage to the cerebellar vermis in chronic alcoholism: a contribution from neurotoxicology to an old problem of selective vulnerabilityQ41639728
Long-term AAV vector gene and protein expression in mouse brain from a small pan-cellular promoter is similar to neural cell promotersQ42199204
Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter.Q42247655
Mutant ataxin-3 with an abnormally expanded polyglutamine chain disrupts dendritic development and metabotropic glutamate receptor signaling in mouse cerebellar Purkinje cells.Q42275945
Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC.Q42502571
Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytesQ42739394
Crossing the rubiconQ43103907
RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.Q44964949
CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo.Q45298680
Global gene transfer into the CNS across the BBB after neonatal systemic delivery of single-stranded AAV vectorsQ45417215
In vivo transduction of murine cerebellar Purkinje cells by HIV-derived lentiviral vectorsQ45856519
Modulation of lentiviral vector tropism in cerebellar Purkinje cells in vivo by a lysosomal cysteine protease cathepsin K.Q48334396
The neonatal blood-brain barrier is functionally effective, and immaturity does not explain differential targeting of AAV9.Q48463127
Metabotropic glutamate receptors mGluR2 and mGluR5 are expressed in two non-overlapping populations of Golgi cells in the rat cerebellumQ48853445
Morphological and neurochemical differentiation of large granular layer interneurons in the adult rat cerebellumQ48866588
Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.Q52560509
Suppression of calbindin-D28k expression exacerbates SCA1 phenotype in a disease mouse model.Q54339710
Screening for proteins with polyglutamine expansions in autosomal dominant cerebellar ataxiasQ57969464
P4510describes a project that usesImageJQ1659584
P921main subjectneurodegenerationQ1755122
P304page(s)14032
P577publication date2014-08-06
P1433published inMolecular Therapy. Methods & Clinical DevelopmentQ27725341
P1476titleDistinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model
P478volume1

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