High levels of homocysteine results in cerebral amyloid angiopathy in mice

scientific article

High levels of homocysteine results in cerebral amyloid angiopathy in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3233/JAD-141101
P932PMC publication ID4362675
P698PubMed publication ID25061050

P2093author name stringDomenico Praticò
Jian-Guo Li
P2860cites workAmyloid beta40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice.Q48492184
MK886 reduces cerebral amyloid angiopathy severity in TgCRND8 miceQ49051978
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Lifelong management of amyloid-beta metabolism to prevent Alzheimer's disease.Q53441656
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Cerebral amyloid angiopathyQ83826066
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Homocysteine and Alzheimer's diseaseQ28185747
Apolipoprotein E: cholesterol transport protein with expanding role in cell biologyQ28294791
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LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β.Q29976920
Neuronal clearance of amyloid-β by endocytic receptor LRP1.Q29977780
Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's diseaseQ30444790
Induction of hyperhomocysteinemia models vascular dementia by induction of cerebral microhemorrhages and neuroinflammationQ30586714
Homocysteine metabolismQ33711793
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrierQ33928434
Plasma homocysteine as a risk factor for dementia and Alzheimer's diseaseQ33957399
Cerebral amyloid angiopathies: a pathologic, biochemical, and genetic viewQ34268430
Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunologyQ34738708
Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?Q35175404
Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tanglesQ35185115
Predicting sites of new hemorrhage with amyloid imaging in cerebral amyloid angiopathyQ36103875
The cerebral beta-amyloid angiopathies: hereditary and sporadicQ36448518
Selective targeting of perivascular macrophages for clearance of beta-amyloid in cerebral amyloid angiopathy.Q37079075
Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer diseaseQ37613107
LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.Q40528558
SDS-stable complex formation between native apolipoprotein E3 and beta-amyloid peptidesQ40836314
Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: the CERAD experience, Part XV.Q46675546
Is Alzheimer's disease an apolipoprotein E amyloidosis?Q46974350
Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levelsQ46975024
P433issue1
P921main subjectcerebral amyloid angiopathyQ191562
P304page(s)29-35
P577publication date2015-01-01
P1433published inJournal of Alzheimer's DiseaseQ6294755
P1476titleHigh levels of homocysteine results in cerebral amyloid angiopathy in mice
P478volume43

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cites work (P2860)
Q99608983Abnormal Homocysteine Metabolism: An Insight of Alzheimer's Disease from DNA Methylation
Q38779069Animal Models of Vascular Cognitive Impairment and Dementia (VCID).
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Q54979717Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy.
Q91410845Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35
Q37104293Hyperhomocysteinemia exacerbates Alzheimer's disease pathology by way of the β-amyloid fibrinogen interaction
Q38896912Hyperhomocysteinemia impairs regional blood flow: involvements of endothelial and neuronal nitric oxide.
Q83229361Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity
Q35158376Is Dysregulation of the HPA-Axis a Core Pathophysiology Mediating Co-Morbid Depression in Neurodegenerative Diseases?
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Q28068353Potential Links between Impaired One-Carbon Metabolism Due to Polymorphisms, Inadequate B-Vitamin Status, and the Development of Alzheimer's Disease
Q41353649Sleep mediates the association between homocysteine and oxidative status in mild cognitive impairment

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