The anti-cancer and anti-inflammatory actions of 1,25(OH)₂D₃

scientific article

The anti-cancer and anti-inflammatory actions of 1,25(OH)₂D₃ is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.BEEM.2011.05.001
P932PMC publication ID3164534
P698PubMed publication ID21872801
P5875ResearchGate publication ID51600842

P2093author name stringD Feldman
A Krishnan
R Bouillon
A Verstuyf
E Vanoirbeek
G Eelen
L Verlinden
P2860cites work1 alpha,25-dihydroxyvitamin D(3) inhibits angiogenesis in vitro and in vivoQ74113984
The Vitamin D analogue TX 527 blocks NF-kappaB activation in peripheral blood mononuclear cells of patients with Crohn's diseaseQ79267816
Vitamin D and cancerQ79369886
Immunohistochemical expression of Ki-67 antigen, cox-2 and Bax/Bcl-2 in prostate cancer; prognostic value in biopsies and radical prostatectomy specimensQ81156632
Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced PTEN upregulationQ24296637
Modulation of the vitamin D3 response by cancer-associated mutant p53Q24302430
15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancersQ24318523
Unraveling insulin-like growth factor binding protein-3 actions in human diseaseQ24650060
Regulation of multiple insulin-like growth factor binding protein genes by 1alpha,25-dihydroxyvitamin D3.Q24816287
Regulation of the human p21(waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor.Q25256835
Cancer-related inflammationQ27860907
Vitamin D.Q27919675
Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issuesQ28192400
Cyclooxygenase-2 and prostate carcinogenesisQ28195207
Aspirin and colon cancer--targeting prevention?Q28211364
Inflammation and breast cancer. Cyclooxygenase/prostaglandin signaling and breast cancerQ28218639
Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofenQ28377754
Calcitriol-induced apoptosis in LNCaP cells is blocked by overexpression of Bcl-2Q28378170
The vitamin D receptor is present in caveolae-enriched plasma membranes and binds 1 alpha,25(OH)2-vitamin D3 in vivo and in vitroQ28580194
NF-kappaB at the crossroads of life and deathQ29619302
Molecular mechanisms of breast cancer metastases to boneQ30436458
Treatment of K562 cells with 1,25-dihydroxyvitamin D3 induces distinct alterations in the expression of apoptosis-related genes BCL2, BAX, BCLXL, and p21.Q39846248
Calbindin-D28K prevents drug-induced dopaminergic neuronal death by inhibiting caspase and calpain activityQ39991930
1alpha,25-dihydroxyvitamin D3 (Calcitriol) inhibits hypoxia-inducible factor-1/vascular endothelial growth factor pathway in human cancer cellsQ40146275
Inhibition of bone resorption, rather than direct cytotoxicity, mediates the anti-tumour actions of ibandronate and osteoprotegerin in a murine model of breast cancer bone metastasis.Q40210622
15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancerQ40248466
Identification and characterization of a response element in the EGFR promoter that mediates transcriptional repression by 1,25-dihydroxyvitamin D3 in breast cancer cellsQ40387192
Vitamin D sensitizes breast cancer cells to the action of H2O2: mitochondria as a convergence point in the death pathwayQ40407718
Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death.Q40419639
Cyclooxygenase inhibitors suppress aromatase expression and activity in breast cancer cells.Q40462696
Vitamin D enhances caspase-dependent and independent TNF-induced breast cancer cell death: the role of reactive oxygen speciesQ40576095
Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasmQ40637846
1alpha,25-Dihydroxyvitamin D3 down-regulates estrogen receptor abundance and suppresses estrogen actions in MCF-7 human breast cancer cellsQ40859289
Regulation of estrogen receptor-alpha gene expression by 1, 25-dihydroxyvitamin D in MCF-7 cellsQ40916283
Effects of a new synthetic vitamin D analogue, EB1089, on the oestrogen-responsive growth of human breast cancer cellsQ41464042
Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.Q41628042
Increased NF-kappaB activity in fibroblasts lacking the vitamin D receptorQ42491472
Involvement of different nuclear hormone receptors in butyrate-mediated inhibition of inducible NF kappa B signallingQ42513043
Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma.Q42514552
Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.Q42859934
Photoprotection by 1alpha,25-dihydroxyvitamin D and analogs: further studies on mechanisms and implications for UV-damageQ43095700
Suppression of RelB-mediated manganese superoxide dismutase expression reveals a primary mechanism for radiosensitization effect of 1alpha,25-dihydroxyvitamin D(3) in prostate cancer cellsQ43116169
Vitamin D may reduce prostate cancer metastasis by several mechanisms including blocking Stat3.Q43245600
A phase II trial of calcitriol and naproxen in recurrent prostate cancer.Q43295148
Demonstration of proteinase inhibitors cystatin A, B and C in breast cancer and in cell lines MCF-7 and ZR-75-1.Q43587581
Aromatase and COX-2 expression in human breast cancersQ43890516
COX-2 in cancer--a player that's defining the rulesQ43963620
The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibitionQ43976249
1,25-Dihydroxyvitamin D down-regulates cell membrane growth- and nuclear growth-promoting signals by the epidermal growth factor receptorQ44104172
Vitamin D receptor is not required for the rapid actions of 1,25-dihydroxyvitamin D3 to increase intracellular calcium and activate protein kinase C in mouse osteoblastsQ44309207
Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1Q44427386
Anti-endothelial properties of 1,25-dihydroxy-3-epi-vitamin D3, a natural metabolite of calcitriolQ44958288
Regulation of prostaglandin metabolism by calcitriol attenuates growth stimulation in prostate cancer cellsQ46051825
Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D.Q46058683
Membrane initiated signaling by 1,25alpha-dihydroxyvitamin D3 in LNCaP prostate cancer cellsQ46581468
Vitamin D receptor (VDR) ablation alters carcinogen-induced tumorigenesis in mammary gland, epidermis and lymphoid tissuesQ46660080
Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates.Q51803777
Comparative effects of 1,25(OH)2D3 and EB1089 on cell cycle kinetics and apoptosis in MCF-7 breast cancer cells.Q52525004
Vitamin D inhibits the formation of prostatic intraepithelial neoplasia in Nkx3.1;Pten mutant mice.Q53341307
Regulation of transforming growth factor-beta type II receptor expression in human breast cancer MCF-7 cells by vitamin D3 and its analogues.Q54141728
Autophagy as a basis for the health-promoting effects of vitamin DQ59487775
Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) geneQ71826297
Vitamin D receptors in breast cancer cellsQ72607738
1,25-dihydroxyvitamin D3 and malignant melanoma: the presence of receptors and inhibition of cell growth in cultureQ72878839
1,25-Dihydroxyvitamin D3 decreases human prostate cancer cell adhesion and migrationQ73064955
Vitamin D analogues suppress IGF-I signalling and promote apoptosis in breast cancer cellsQ73446751
Tissue-selective regulation of aromatase expression by calcitriol: implications for breast cancer therapyQ33577548
MicroRNAs181 regulate the expression of p27Kip1 in human myeloid leukemia cells induced to differentiate by 1,25-dihydroxyvitamin D3Q33583422
Down-regulation of NF-kappa B protein levels in activated human lymphocytes by 1,25-dihydroxyvitamin D3.Q33748424
Genomic vitamin D signaling in breast cancer: Insights from animal models and human cells.Q34005554
Aromatase--a brief overviewQ34112633
Epigenetic control of a VDR-governed feed-forward loop that regulates p21(waf1/cip1) expression and function in non-malignant prostate cellsQ34723871
Suppression of prostate cancer cell rolling and adhesion to endothelium by 1α,25-dihydroxyvitamin D3.Q34756280
The iroquois homeobox gene 5 is regulated by 1,25-dihydroxyvitamin D3 in human prostate cancer and regulates apoptosis and the cell cycle in LNCaP prostate cancer cellsQ34783905
The seed and soil hypothesis revisited--the role of tumor-stroma interactions in metastasis to different organsQ34784896
Vitamin D-3 receptor as a target for breast cancer preventionQ35168696
Pathways mediating the growth-inhibitory actions of vitamin D in prostate cancerQ35168714
Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3Q35462970
Aromatase in bone: roles of Vitamin D3 and androgensQ35586812
Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammationQ35803526
Vitamin D and colon carcinogenesisQ35966627
Aromatase inhibition: translation into a successful therapeutic approachQ36101447
Calcium signaling in cancer and vitamin D.Q36218906
Targeting cyclooxygenase-2 for prevention and therapy of colorectal cancerQ36475129
Inflammation in prostate carcinogenesisQ36554784
Stat3 promotes metastatic progression of prostate cancer.Q36691140
Vitamin D signalling pathways in cancer: potential for anticancer therapeuticsQ36919979
Vitamin D and cancer incidence in the Harvard cohortsQ37091386
Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor-derived endothelial cells and tumor angiogenesis in vivoQ37363014
Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1alpha,25(OH)2-vitamin D3 signalingQ37511791
The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literatureQ37576901
The role of vitamin D in cancer prevention and treatmentQ37761548
Growth factors in the regulation of pericellular proteolysis: a reviewQ38201615
Insulin-like growth factor binding protein-3 mediates 1 alpha,25-dihydroxyvitamin d(3) growth inhibition in the LNCaP prostate cancer cell line through p21/WAF1.Q38303196
1alpha, 25-dihydroxyvitamin D3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis.Q38314103
Cyclooxygenase-2 (COX-2) expression is an independent predictor of prostate cancer recurrenceQ38438329
Expression of calbindin-D28k is inversely correlated with proapototic gene expression in hydrogen peroxide-induced cell death in endometrial cancer cellsQ39604006
Vitamin D inhibits CEACAM1 to promote insulin/IGF-I receptor signaling without compromising anti-proliferative actionQ39666830
Involvement of stress activated protein kinases (JNK and p38) in 1,25 dihydroxyvitamin D3-induced breast cell deathQ39676692
Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasisQ39738745
The transcription factors Snail1 and Snail2 repress vitamin D receptor during colon cancer progressionQ39742532
P433issue4
P304page(s)593-604
P577publication date2011-08-01
P1433published inBest Practice and Research: Clinical Endocrinology and MetabolismQ15755890
P1476titleThe anti-cancer and anti-inflammatory actions of 1,25(OH)₂D₃
P478volume25

Reverse relations

cites work (P2860)
Q339568881, 25(OH)₂D₃ inhibits hepatocellular carcinoma development through reducing secretion of inflammatory cytokines from immunocytes
Q902103571,25(OH)2D3 improves blood lipid metabolism, liver function, and atherosclerosis by constraining the TGF-β/Smad signaling pathway in rats with hyperlipidemia
Q3770055025-Hydroxyvitamin D and ankle-brachial blood pressure index in adults without peripheral artery disease.
Q34135803A review of the application of inflammatory biomarkers in epidemiologic cancer research
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Q52649198Potential Use of 1-25-dihydroxyvitamin D in the Diagnosis and Treatment of Papillary Thyroid Cancer.
Q35046497Primary 1,25-dihydroxyvitamin D3 response of the interleukin 8 gene cluster in human monocyte- and macrophage-like cells
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Q37061744Vitamin d: pharmacokinetics and safety when used in conjunction with the pharmaceutical drugs used in cancer patients: a systematic review

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