A phase 1 trial dose-escalation study of tipifarnib on a week-on, week-off schedule in relapsed, refractory or high-risk myeloid leukemia

scientific article

A phase 1 trial dose-escalation study of tipifarnib on a week-on, week-off schedule in relapsed, refractory or high-risk myeloid leukemia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/LEU.2011.124
P932PMC publication ID3165084
P698PubMed publication ID21625235
P5875ResearchGate publication ID51177313

P50authorTimothy SynoldQ78536675
P2093author name stringJ Wright
J Tuscano
P Frankel
S J Forman
C Karanes
M R O'Donnell
E M Newman
A S Stein
L Popplewell
J M Zain
B Pulone
A Rincon
M H Kirschbaum
P2860cites workIntermittent dosing of the farnesyl transferase inhibitor tipifarnib (R115777) in advanced malignant solid tumors: a phase I California Cancer Consortium TrialQ33364989
Ras protein farnesyltransferase: A strategic target for anticancer therapeutic developmentQ33767883
Clinical development of farnesyltransferase inhibitors in leukemias and myelodysplastic syndromeQ35007250
Farnesyl transferase inhibitors in the treatment of breast cancerQ35073354
A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemiaQ35628954
Mechanisms of resistance to 5-aza-2'-deoxycytidine in human cancer cell linesQ37066258
A 2-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemiaQ40030598
A phase 2 study of the oral farnesyltransferase inhibitor tipifarnib in patients with refractory or relapsed acute myeloid leukemia.Q40455631
Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid LeukemiaQ40543180
Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?Q41094489
Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trialQ43615357
Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancerQ44012109
Dose-ranging pharmacodynamic study of tipifarnib (R115777) in patients with relapsed and refractory hematologic malignanciesQ45166768
Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancerQ73445688
Clinical and pharmacologic study of the farnesyltransferase inhibitor tipifarnib in cancer patients with normal or mildly or moderately impaired hepatic functionQ79157124
Pharmacokinetics of tipifarnib after oral and intravenous administration in subjects with advanced cancerQ80305635
P433issue10
P921main subjectphase I clinical trialQ5452194
P304page(s)1543-1547
P577publication date2011-05-31
P1433published inLeukemiaQ6534498
P1476titleA phase 1 trial dose-escalation study of tipifarnib on a week-on, week-off schedule in relapsed, refractory or high-risk myeloid leukemia
P478volume25

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cites work (P2860)
Q34587614Four different regimens of farnesyltransferase inhibitor tipifarnib in older, untreated acute myeloid leukemia patients: North American Intergroup Phase II study SWOG S0432.
Q34052520Molecular pathways: targeting NRAS in melanoma and acute myelogenous leukemia
Q38097334Pediatric relapsed or refractory leukemia: new pharmacotherapeutic developments and future directions
Q49501093Phase I study of sorafenib and tipifarnib for recurrent glioblastoma: NABTC 05-02.
Q47605042Prediction of Apparent Oral Clearance of Small-Molecule Inhibitors in Pediatric Patients
Q38058956Recent advances in protein prenyltransferases: substrate identification, regulation, and disease interventions
Q33614140Tipifarnib prevents development of hypoxia-induced pulmonary hypertension.
Q38386344Treatment of NRAS-mutant melanoma.
Q36373227Treatment of human pre-B acute lymphoblastic leukemia with the Aurora kinase inhibitor PHA-739358 (Danusertib)

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