Recombination can either help maintain very short telomeres or generate longer telomeres in yeast cells with weak telomerase activity

scientific article

Recombination can either help maintain very short telomeres or generate longer telomeres in yeast cells with weak telomerase activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/EC.05079-11
P932PMC publication ID3165439
P698PubMed publication ID21666075

P2093author name stringMichael J McEachern
Zeki Topcu
Evelina Basenko
P2860cites workShort telomeres initiate telomere recombination in primary and tumor cellsQ21145014
Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenanceQ27930358
EXO1 contributes to telomere maintenance in both telomerase-proficient and telomerase-deficient Saccharomyces cerevisiaeQ27933420
Mrc1, a non-essential DNA replication protein, is required for telomere end protection following loss of capping by Cdc13, Yku or telomeraseQ27933870
Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination eventsQ27936385
Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13.Q27937259
Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13Q27938764
Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particleQ28144506
Break-induced replication and recombinational telomere elongation in yeastQ28244552
An alternative pathway for yeast telomere maintenance rescues est1- senescenceQ29616135
TLC1: template RNA component of Saccharomyces cerevisiae telomeraseQ29618197
Telomeres and diseaseQ33347458
Telomeric circles are abundant in the stn1-M1 mutant that maintains its telomeres through recombinationQ33566396
Recombination at long mutant telomeres produces tiny single- and double-stranded telomeric circlesQ33836966
Extrachromosomal telomeric circles contribute to Rad52-, Rad50-, and polymerase delta-mediated telomere-telomere recombination in Saccharomyces cerevisiae.Q33859427
Recombination in telomere-length maintenanceQ33885436
Abrupt disruption of capping and a single source for recombinationally elongated telomeres in Kluyveromyces lactisQ33927486
Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cellsQ33968413
Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loopsQ33982700
An mre11 mutation that promotes telomere recombination and an efficient bypass of senescenceQ34007895
Intrachromatid excision of telomeric DNA as a mechanism for telomere size control in Saccharomyces cerevisiaeQ34012288
The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiaeQ34035073
A mutation in the STN1 gene triggers an alternative lengthening of telomere-like runaway recombinational telomere elongation and rapid deletion in yeastQ34042826
Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombinationQ34083558
Alternative lengthening of telomeres: models, mechanisms and implicationsQ34107386
A telomeric repeat sequence adjacent to a DNA double-stranded break produces an anticheckpointQ34116944
Involvement of replicative polymerases, Tel1p, Mec1p, Cdc13p, and the Ku complex in telomere-telomere recombination.Q34284992
RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomeraseQ34606774
Recombination can cause telomere elongations as well as truncations deep within telomeres in wild-type Kluyveromyces lactis cellsQ34739230
Short telomeres induce a DNA damage response in Saccharomyces cerevisiaeQ34813172
Specific telomerase RNA residues distant from the template are essential for telomerase functionQ35210631
A novel pseudoknot element is essential for the action of a yeast telomeraseQ35966681
Telomere cap components influence the rate of senescence in telomerase-deficient yeast cellsQ36222630
Factors influencing the recombinational expansion and spread of telomeric tandem arrays in Kluyveromyces lactisQ36370415
Telomere loops and homologous recombination-dependent telomeric circles in a Kluyveromyces lactis telomere mutant strain.Q36421126
Telomeres: cancer to human agingQ36528826
Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cellsQ36827578
Characterization of a positive regulatory gene, LAC9, that controls induction of the lactose-galactose regulon of Kluyveromyces lactis: structural and functional relationships to GAL4 of Saccharomyces cerevisiaeQ36837016
Mutant telomeric repeats in yeast can disrupt the negative regulation of recombination-mediated telomere maintenance and create an alternative lengthening of telomeres-like phenotypeQ37072132
Evidence for an additional base-pairing element between the telomeric repeat and the telomerase RNA template in Kluyveromyces lactis and other yeastsQ37374743
Genetic dissection of the Kluyveromyces lactis telomere and evidence for telomere capping defects in TER1 mutants with long telomeresQ37421748
DNA damage checkpoint inactivation: adaptation and recoveryQ37493574
Senescence and life spanQ37599560
Senescence: an antiviral defense that is tumor suppressive?Q37627019
Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers.Q37764530
When the caps fall off: responses to telomere uncapping in yeastQ37769833
Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiaeQ39449233
Recombinational telomere elongation promoted by DNA circlesQ39675010
The Rad51 pathway of telomerase-independent maintenance of telomeres can amplify TG1-3 sequences in yku and cdc13 mutants of Saccharomyces cerevisiae.Q39753325
The role of recombination in telomere length maintenanceQ39851594
Unusual telomeric DNAs in human telomerase-negative immortalized cellsQ39915528
Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.Q40169716
Alternative lengthening of telomeres is characterized by high rates of telomeric exchange.Q40571053
Template requirements for telomerase translocation in Kluyveromyces lactisQ40581690
Absence of a telomere maintenance mechanism as a favorable prognostic factor in patients with osteosarcomaQ40593218
Effects of reconstitution of telomerase activity on telomere maintenance by the alternative lengthening of telomeres (ALT) pathwayQ40780747
Telomere maintenance by telomerase and by recombination can coexist in human cellsQ40780754
Telomerase can inhibit the recombination-based pathway of telomere maintenance in human cellsQ40800667
Template boundary in a yeast telomerase specified by RNA structureQ41734113
Homologous recombination in Candida albicans: role of CaRad52p in DNA repair, integration of linear DNA fragments and telomere lengthQ45014791
Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomeraseQ46140748
Runaway telomere elongation caused by telomerase RNA gene mutationsQ46144742
A novel mechanism for telomere size control in Saccharomyces cerevisiaeQ47331172
Telomere maintenance is dependent on activities required for end repair of double-strand breaksQ47946099
Screening for telomeric recombination in wild-type Kluyveromyces lactis.Q53626385
Short telomeres in yeast are highly recombinogenicQ73835292
Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) bodyQ78257210
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activityQ84946960
P433issue8
P304page(s)1131-1142
P577publication date2011-06-10
P1433published inEukaryotic CellQ5408685
P1476titleRecombination can either help maintain very short telomeres or generate longer telomeres in yeast cells with weak telomerase activity
P478volume10

Reverse relations

cites work (P2860)
Q41218560Early telomerase inactivation accelerates aging independently of telomere length
Q36210968Maintenance of very long telomeres by recombination in the Kluyveromyces lactis stn1-M1 mutant involves extreme telomeric turnover, telomeric circles, and concerted telomeric amplification
Q37167899Monopolin recruits condensin to organize centromere DNA and repetitive DNA sequences
Q49803981Telomere Length Maintenance in Cancer: At the Crossroad between Telomerase and Alternative Lengthening of Telomeres (ALT).

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