Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes

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Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1101/GR.118042.110
P932PMC publication ID3166826
P698PubMed publication ID21750107
P5875ResearchGate publication ID51486597

P50authorHendrik Gerard StunnenbergQ85416865
P2093author name stringFragiskos N Kolisis
Kees-Jan Francoijs
Aristotelis Chatziioannou
Dimitra J Mitsiou
Melysia T McCalman
Michael N Alexis
Nagesha A S Rao
Panagiotis Moulos
P2860cites workOverexpressed glucocorticoid receptor negatively regulates gene expression under conditions that favour accumulation of non-hormone-binding forms of the receptorQ73308137
Model-based analysis of ChIP-Seq (MACS)Q21183902
Identification of novel functional TBP-binding sites and general factor repertoiresQ24295026
Disassembly of transcriptional regulatory complexes by molecular chaperonesQ24300055
Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibitionQ24317463
Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptorQ24561876
WebGestalt: an integrated system for exploring gene sets in various biological contextsQ24813284
Glucocorticoid receptor-dependent gene regulatory networks.Q24813377
A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptorsQ27860552
A framework for collaborative analysis of ENCODE data: making large-scale analyses biologist-friendlyQ28306159
An oestrogen-receptor-α-bound human chromatin interactomeQ29541719
Shared principles in NF-kappaB signalingQ29547234
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseasesQ29547555
Genome-wide analysis of estrogen receptor binding sitesQ29614765
A global view of gene activity and alternative splicing by deep sequencing of the human transcriptomeQ29615877
Regulation and function of NF-kappaB transcription factors in the immune systemQ29616427
Steroid hormone receptors: many actors in search of a plotQ29618397
Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machineryQ29620335
Gene ARMADA: an integrated multi-analysis platform for microarray data implemented in MATLAB.Q30491356
Whole-genome cartography of estrogen receptor alpha binding sitesQ33286418
Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptorQ33287197
Pro-inflammatory signaling: last pieces in the NF-kappaB puzzle?Q33368441
The human glucocorticoid receptor: molecular basis of biologic functionQ33620765
Minireview: latest perspectives on antiinflammatory actions of glucocorticoidsQ33670499
GimmeMotifs: a de novo motif prediction pipeline for ChIP-sequencing experimentsQ33748357
Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12.Q33915125
PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia.Q34099047
A hierarchy of H3K4me3 and H3K27me3 acquisition in spatial gene regulation in Xenopus embryos.Q35003305
Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement.Q35029015
Mechanism of action of a distal NF-kappaB-dependent enhancerQ35071013
Molecular mechanisms of glucocorticoid action and resistanceQ35089953
The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repressionQ35200339
Mechanisms of glucocorticoid receptor action in noninflammatory and inflammatory cellsQ36236890
Distribution of NF-kappaB-binding sites across human chromosome 22Q36349337
Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesisQ36960979
Glucocorticoid receptor activation of the Ciz1-Lcn2 locus by long range interactionsQ37112229
ChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligandsQ37207706
The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insightsQ37732574
Diversity in post-transcriptional control of neutrophil chemoattractant cytokine gene expressionQ37739651
Crosstalk between TNF and glucocorticoid receptor signaling pathwaysQ37748052
Characterization of genome-wide p53-binding sites upon stress response.Q38291053
Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivoQ38328562
Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormoneQ38339139
Steroid receptor regulated transcription of specific genes and gene networksQ39838638
Genome-wide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NF-kappaB upon TLR4 activationQ40091968
Molecular mechanisms of anti-inflammatory action of glucocorticoidsQ40992149
An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormonesQ41183764
Mechanism of gene expression by the glucocorticoid receptor: role of protein-protein interactionsQ41359169
Nuclear factor-kappa B.Q41598098
Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulationQ41954335
STAMP: a web tool for exploring DNA-binding motif similaritiesQ42055929
Triamcinolone acetonide and dexamethasome suppress TNF-alpha-induced histone H4 acetylation on lysine residues 8 and 12 in mononuclear cellsQ44251723
New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable?Q44607623
Multiple and cooperative trans-activation domains of the human glucocorticoid receptorQ46099369
Transcriptional cross-talk, the second mode of steroid hormone receptor actionQ47862003
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)1404-1416
P577publication date2011-07-12
P1433published inGenome ResearchQ5533485
P1476titleCoactivation of GR and NFKB alters the repertoire of their binding sites and target genes
P478volume21

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cites work (P2860)
Q92106947A General Introduction to Glucocorticoid Biology
Q37333813A conserved protein motif is required for full modulatory activity of negative elongation factor subunits NELF-A and NELF-B in modifying glucocorticoid receptor-regulated gene induction properties
Q41287485A high-throughput chemical screen identifies novel inhibitors and enhancers of anti-inflammatory functions of the glucocorticoid receptor
Q28673956A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics
Q35914950A novel comparative pattern count analysis reveals a chronic ethanol-induced dynamic shift in immediate early NF-κB genome-wide promoter binding during liver regeneration.
Q37122058A probabilistic approach to learn chromatin architecture and accurate inference of the NF-κB/RelA regulatory network using ChIP-Seq.
Q36368244Activation of NF-κB protein prevents the transition from juvenile ovary to testis and promotes ovarian development in zebrafish
Q40795476Acute TNF-induced repression of cell identity genes is mediated by NFκB-directed redistribution of cofactors from super-enhancers
Q36700004Antenatal glucocorticoids counteract LPS changes in TGF-β pathway and caveolin-1 in ovine fetal lung
Q40096656Anti-Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action
Q55011508BRG1 governs glucocorticoid receptor interactions with chromatin and pioneer factors across the genome.
Q24311305Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation
Q36898515C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements
Q39305340Checks and balances: The glucocorticoid receptor and NFĸB in good times and bad.
Q26825836Chromatin architecture defines the glucocorticoid response
Q37066464Cistrome-based Cooperation between Airway Epithelial Glucocorticoid Receptor and NF-κB Orchestrates Anti-inflammatory Effects
Q33727032Class I lysine deacetylases promote glucocorticoid-induced transcriptional repression through functional interaction with LSD1.
Q31113363Complex genomic interactions in the dynamic regulation of transcription by the glucocorticoid receptor
Q37653249Context-dependent cooperation between nuclear factor κB (NF-κB) and the glucocorticoid receptor at a TNFAIP3 intronic enhancer: a mechanism to maintain negative feedback control of inflammation
Q57021399Corticosteroid Receptors in the Brain: Transcriptional Mechanisms for Specificity and Context-Dependent Effects
Q64290531Corticosteroid signaling at the brain-immune interface impedes coping with severe psychological stress
Q38743542Crosstalk between androgen and pro-inflammatory signaling remodels androgen receptor and NF-κB cistrome to reprogram the prostate cancer cell transcriptome.
Q55340271Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements.
Q38669676Early life stress perturbs the function of microglia in the developing rodent brain: New insights and future challenges
Q42241153Effects of coupled dose and rhythm manipulation of plasma cortisol levels on leukocyte transcriptional response to endotoxin challenge in humans
Q35072532Effects of intra-amniotic lipopolysaccharide and maternal betamethasone on brain inflammation in fetal sheep
Q35856573Elucidating the identity of resistance mechanisms to prednisolone exposure in acute lymphoblastic leukemia cells through transcriptomic analysis: A computational approach.
Q47142116Epigenetic mechanisms underlie the crosstalk between growth factors and a steroid hormone
Q64098881Expanding the repertoire of glucocorticoid receptor target genes by engineering genomic response elements
Q35747484Experience and the ever-changing brain: what the transcriptome can reveal
Q92113184Expression of SAA1, SAA2 and SAA4 genes in human primary monocytes and monocyte-derived macrophages
Q64103107Extensive epigenomic integration of the glucocorticoid response in primary human monocytes and in vitro derived macrophages
Q92800308Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid Receptor
Q34672342Functional characterization of a competitive peptide antagonist of p65 in human macrophage-like cells suggests therapeutic potential for chronic inflammation
Q50101639Gene-specific mechanisms direct Glucocorticoid Receptor-driven repression of inflammatory response genes in macrophages
Q94545085General Adaptation in Critical Illness: Glucocorticoid Receptor-alpha Master Regulator of Homeostatic Corrections
Q34700511Genetic, functional and molecular features of glucocorticoid receptor binding
Q30274762Genome-Wide Identification of Basic Helix-Loop-Helix and NF-1 Motifs Underlying GR Binding Sites in Male Rat Hippocampus.
Q30277994Genome-wide predictors of NF-κB recruitment and transcriptional activity
Q38402788Genomic and epigenomic mechanisms of glucocorticoids in the brain
Q39053368Genomic effects of glucocorticoids.
Q35617705Global gene expression analysis in human uterine epithelial cells defines new targets of glucocorticoid and estradiol antagonism
Q46081306Glucocorticoid Receptor:MegaTrans Switching Mediates the Repression of an ERα-Regulated Transcriptional Program.
Q39637172Glucocorticoid and TNF signaling converge at A20 (TNFAIP3) to repress airway smooth muscle cytokine expression
Q39173501Glucocorticoid and cytokine crosstalk: Feedback, feedforward, and co-regulatory interactions determine repression or resistance
Q36335676Glucocorticoid receptor and nuclear factor kappa-b affect three-dimensional chromatin organization
Q34048336Glucocorticoid receptor coordinates transcription factor-dominated regulatory network in macrophages.
Q51093091Glucocorticoid-Induced Osteoporosis.
Q28077040Glucocorticoid-independent modulation of GR activity: Implications for immunotherapy
Q47144286Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages.
Q64077434Glucocorticoid-resistant B cell acute lymphoblastic leukemia displays receptor tyrosine kinase activation
Q91898018Glucocorticoids inhibit macrophage differentiation towards a pro-inflammatory phenotype upon wounding without affecting their migration
Q35023017Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M.
Q37228895HOXA1 binds RBCK1/HOIL-1 and TRAF2 and modulates the TNF/NF-κB pathway in a transcription-independent manner
Q31146112Hippocampal gene expression changes underlying stress sensitization and recovery
Q36436018Identification of location and kinetically defined mechanism of cofactors and reporter genes in the cascade of steroid-regulated transactivation
Q38697912Interferon-Stimulated Genes Are Transcriptionally Repressed by PR in Breast Cancer
Q39369459Involvement of miR17 pathway in glucocorticoid-induced cell death in pediatric acute lymphoblastic leukemia
Q30717456Large-scale quality analysis of published ChIP-seq data
Q48105513Long-acting β2-agonists promote glucocorticoid-mediated repression of NF-κB by enhancing expression of the feedback regulator TNFAIP3.
Q59125995Mechanisms of NF-κB p65 and strategies for therapeutic manipulation
Q26829103Minireview: Conversing with chromatin: the language of nuclear receptors
Q37372312Molecular Signatures of Membrane Protein Complexes Underlying Muscular Dystrophy.
Q90099983Nascent transcript analysis of glucocorticoid crosstalk with TNF defines primary and cooperative inflammatory repression
Q38951098New Insights in Glucocorticoid Receptor Signaling-More Than Just a Ligand-Binding Receptor
Q36931088Nuclear receptor REV-ERBα mediates circadian sensitivity to mortality in murine vesicular stomatitis virus-induced encephalitis
Q37209671Nuclear receptors in inflammation control: repression by GR and beyond.
Q46184189Nutritional marginal zinc deficiency disrupts placental 11β-hydroxysteroid dehydrogenase type 2 modulation
Q42369143Plasmodium berghei NK65 in Combination with IFN-γ Induces Endothelial Glucocorticoid Resistance via Sustained Activation of p38 and JNK.
Q47616328Protective effect of dexamethasone on 5-FU-induced oral mucositis in hamsters
Q98176768Psychiatric face of COVID-19
Q35121856Quantitation of glucocorticoid receptor DNA-binding dynamics by single-molecule microscopy and FRAP
Q34659988Recognizing Resilience: Learning from the Effects of Stress on the Brain
Q58114028Requirement for NF-κB in maintenance of molecular and behavioral circadian rhythms in mice
Q36122756Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids.
Q41941328SUMOylation regulates the chromatin occupancy and anti-proliferative gene programs of glucocorticoid receptor
Q92971130Signal Integration of IFN-I and IFN-II With TLR4 Involves Sequential Recruitment of STAT1-Complexes and NFκB to Enhance Pro-inflammatory Transcription
Q41815633Small-molecule hormones: molecular mechanisms of action
Q37258166Social environmental effects on gene regulation
Q34501482Spatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation.
Q36397888Stress and glucocorticoid receptor transcriptional programming in time and space: Implications for the brain-gut axis
Q35269181TNFα signaling exposes latent estrogen receptor binding sites to alter the breast cancer cell transcriptome
Q36946277Targeting Endothelial Adhesion Molecule Transcription for Treatment of Inflammatory Disease: A Proof-of-Concept Study.
Q38832434The Interactome of the Glucocorticoid Receptor and Its Influence on the Actions of Glucocorticoids in Combatting Inflammatory and Infectious Diseases
Q30540388The PinkThing for analysing ChIP profiling data in their genomic context
Q47316032The emerging role of Hippo signaling pathway in regulating osteoclast formation.
Q36888160The five Rs of glucocorticoid action during inflammation: ready, reinforce, repress, resolve, and restore.
Q46882050The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ.
Q38050401The multiple facets of glucocorticoid action in rheumatoid arthritis
Q38837437There goes the neighborhood: Assembly of transcriptional complexes during the regulation of metabolism and inflammation by the glucocorticoid receptor.
Q58753850Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation
Q42773793Transcriptome Display During Testicular Differentiation of Channel Catfish (Ictalurus punctatus) as Revealed by RNA-Seq Analysis.
Q37598688Vitamin D receptor and CD86 expression in the skin of vitamin D-deficient swine
Q37702277Voluntary exercise blocks Western diet-induced gene expression of the chemokines CXCL10 and CCL2 in the prefrontal cortex
Q34481477mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

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