Role of Δ1-pyrroline-5-carboxylate dehydrogenase supports mitochondrial metabolism and host-cell invasion of Trypanosoma cruzi

scientific article

Role of Δ1-pyrroline-5-carboxylate dehydrogenase supports mitochondrial metabolism and host-cell invasion of Trypanosoma cruzi is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M114.574525
P953full work available at URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367278
P932PMC publication ID4367278
P698PubMed publication ID25623067
P5875ResearchGate publication ID271595647

P50authorErick L BastosQ87713295
Patricio Fernández-SilvaQ58330215
Ariel Mariano SilberQ43626227
P2093author name stringOtavio H Thiemann
Brian S Mantilla
Daiana E Martil
Elizabeth M F Pral
Lisvane S Paes
P2860cites workLife cycle of Trypanosoma cruziQ71804068
Intracellular pH in mammalian stages of Trypanosoma cruzi is K+-dependent and regulated by H+-ATPasesQ73490722
Isolation and subfractionation of mitochondria from the yeast Saccharomyces cerevisiaeQ73944610
The interconversion of glutamic acid and proline. II. The preparation and properties of delta 1-pyrroline-5-carboxylic acidQ79278412
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceQ24286950
The three-dimensional structural basis of type II hyperprolinemiaQ24315802
Determination of domain structure of proteins from X-ray solution scatteringQ24537462
A surface transporter family conveys the trypanosome differentiation signalQ24656663
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Crystal structure of the bifunctional proline utilization A flavoenzyme from Bradyrhizobium japonicumQ27659543
Structural Determinants of Oligomerization of Δ1-Pyrroline-5-Carboxylate Dehydrogenase: Identification of a Hexamerization Hot SpotQ27678545
Amino-terminal fragments of delta 1-pyrroline-5-carboxylate dehydrogenase direct beta-galactosidase to the mitochondrial matrix in Saccharomyces cerevisiaeQ27932493
A simple and efficient method for direct gene deletion in Saccharomyces cerevisiaeQ28131603
Yeast/E. coli shuttle vectors with multiple unique restriction sitesQ28131612
Pyridoxal phosphate de-activation by pyrroline-5-carboxylic acid. Increased risk of vitamin B6 deficiency and seizures in hyperprolinemia type IIQ28141266
Glutamate uptakeQ28190140
Actions of a proline analogue, L-thiazolidine-4-carboxylic acid (T4C), on Trypanosoma cruziQ28474880
Proline modulates the Trypanosoma cruzi resistance to reactive oxygen species and drugs through a novel D, L-proline transporterQ28541003
Purification and characterization of human liver "high Km" aldehyde dehydrogenase and its identification as glutamic gamma-semialdehyde dehydrogenaseQ28646331
Mutations in the Delta1-pyrroline 5-carboxylate dehydrogenase gene cause type II hyperprolinemiaQ28646386
High-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG methodQ29615751
Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active formQ29619372
Deletion analysis of GAL4 defines two transcriptional activating segmentsQ29620547
CRYSOL– a Program to Evaluate X-ray Solution Scattering of Biological Macromolecules from Atomic CoordinatesQ29642130
Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern BrazilQ33608718
Separation of NADH-fumarate reductase and succinate dehydrogenase activities in Trypanosoma cruziQ33838134
Respiratory chain supercomplexes of mitochondria and bacteriaQ33961173
The development of Trypanosoma cruzi in triatominaeQ34010190
Basic cell biology of Trypanosoma cruziQ34541654
Convex Arrhenius plots and their interpretationQ34629994
Structural basis of perturbed pKa values of catalytic groups in enzyme active sitesQ34670783
ATP production in isolated mitochondria of procyclic Trypanosoma bruceiQ46722448
Biochemical characterization of the glutamate transport in Trypanosoma cruzi.Q46864367
Drosophila delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDh) is required for proline breakdown and mitochondrial integrity-Establishing a fly model for human type II hyperprolinemiaQ47070584
Submitochondrial location and electron transport characteristics of enzymes involved in proline oxidationQ47937412
Euglena gracilis and Trypanosomatids possess common patterns in predicted mitochondrial targeting presequences.Q50489238
Differences in the concentration of free amino acids in the haemolymph of adult male and female Rhodnius prolixusQ52439109
In vitro differentiation of Trypanosoma cruzi under chemically defined conditions.Q54445195
Nova tripanozomiaze humana: estudos sobre a morfolojia e o ciclo evolutivo do Schizotrypanum cruzi n. gen., n. sp., ajente etiolojico de nova entidade morbida do homemQ55878589
Automated matching of high- and low-resolution structural modelsQ56444545
Crystal Structure of Thermus thermophilus Δ1-Pyrroline-5-carboxylate DehydrogenaseQ57894832
Interaction with host factors exacerbates Trypanosoma cruzi cell invasion capacity upon oral infectionQ58844822
Mitochondrial bioenergetics and redox state are unaltered in Trypanosoma cruzi isolates with compromised mitochondrial complex I subunit genesQ58858211
GROWTH AND DIFFERENTIATION IN TRYPANOSOMA CRUZI. I. ORIGIN OF METACYCLIC TRYPANOSOMES IN LIQUID MEDIAQ58861039
Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase: structure, catalytic mechanism and targeted inhibitor designQ63431224
Proline metabolism in Trypanosoma cruzi epimastigotesQ67493390
Properties and analysis of a stable derivative of pyrroline-5-carboxylic acid for use in metabolic studiesQ67805395
Accumulation of pyrroline 5-carboxylic acid in conditioned medium of cultured fibroblast: stimulatory effects of serum, insulin, and IGF-1Q68010474
Free aminoacid pool and proteolytic enzymes in Trypanosoma cruzi cultured in vitroQ70301279
A simple method to purify biologically and antigenically preserved bloodstream trypomastigotes of Trypanosoma cruzi using Deae-cellulose columnsQ70309666
Non-linear arrhenius plots and the analysis of reaction and motional rates in biological membranesQ70882341
Glutamate gamma-semialdehyde as a natural transition state analogue inhibitor of Escherichia coli glucosamine-6-phosphate synthaseQ71715135
Global analysis of protein palmitoylation in African trypanosomes.Q34739483
Enolase: a key player in the metabolism and a probable virulence factor of trypanosomatid parasites-perspectives for its use as a therapeutic target.Q34975047
Trypanosoma brucei mitochondrial respiratome: composition and organization in procyclic formQ35264598
Effect of 21 different nitrogen sources on global gene expression in the yeast Saccharomyces cerevisiaeQ35856792
Amino acid metabolic routes in Trypanosoma cruzi: possible therapeutic targets against Chagas' diseaseQ36074405
Protection from the acquisition of Staphylococcus aureus nasal carriage by cross-reactive antibody to a pneumococcal dehydrogenaseQ36187255
Reactive oxygen species homeostasis and virulence of the fungal pathogen Cryptococcus neoformans requires an intact proline catabolism pathwayQ36878614
Proline dehydrogenase regulates redox state and respiratory metabolism in Trypanosoma cruziQ37033593
Structural biology of proline catabolismQ37120243
Particularities of mitochondrial structure in parasitic protists (Apicomplexa and Kinetoplastida).Q37451982
Role of the yeast acetyltransferase Mpr1 in oxidative stress: regulation of oxygen reactive species caused by a toxic proline catabolism intermediateQ37494103
Calmodulin genes in trypanosomes are tandemly repeated and produce multiple mRNAs with a common 5' leader sequenceQ37691316
Mitochondria as a promising antiparasitic targetQ37710656
The uniqueness of the Trypanosoma cruzi mitochondrion: opportunities to identify new drug target for the treatment of Chagas diseaseQ37896113
Role of trypanosomatid's arginase in polyamine biosynthesis and pathogenesisQ37950217
Purification and some properties of the NADP-linked glutamate dehydrogenase from Trypanosoma cruziQ39200359
Protein composition of Trypanosoma brucei mitochondrial membranesQ39709851
Biology of Trypanosoma cruziQ39879813
Improved chemical synthesis and enzymatic assay ofΔ1-pyrroline-5-car☐ylic acidQ39935505
Metabolism of Proline and the HydroxyprolinesQ40121480
Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cellsQ40484418
A comprehensive analysis of Trypanosoma brucei mitochondrial proteomeQ40541943
Intermediate metabolism in Trypanosoma cruziQ40686710
Mitochondrial substrate level phosphorylation is essential for growth of procyclic Trypanosoma bruceiQ40721025
The role of succinate in the respiratory chain of Trypanosoma brucei procyclic trypomastigotesQ41308272
Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase.Q41671726
Use of L-proline and ATP production by Trypanosoma cruzi metacyclic forms as requirements for host cell invasionQ41778659
Purification and partial structural and kinetic characterization of tyrosine aminotransferase from epimastigotes of Trypanosoma cruziQ41808175
The Involvement of Glutamate Metabolism in the Resistance to Thermal, Nutritional, and Oxidative Stress in Trypanosoma cruzi.Q41840211
Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compoundsQ42195429
The uptake of pyrroline 5-carboxylate. Group translocation mediating the transfer of reducing-oxidizing potentialQ42214574
Pyrroline-5-carboxylate in human plasmaQ42256741
A nuclear gene encoding mitochondrial Delta-pyrroline-5-carboxylate dehydrogenase and its potential role in protection from proline toxicity.Q42509489
Human glutamic-gamma-semialdehyde dehydrogenase. Kinetic mechanismQ42836763
Mechanism of Trypanosoma cruzi death induced by Cratylia mollis seed lectin.Q43162297
Functional characterization of stage-specific aminotransferases from trypanosomatidsQ43652334
Proteomic analysis of Trypanosoma cruzi secretome: characterization of two populations of extracellular vesicles and soluble proteins.Q44316258
Biochemical characterization of proline racemases from the human protozoan parasite Trypanosoma cruzi and definition of putative protein signaturesQ44432668
Biochemical characterization of stage-specific isoforms of aspartate aminotransferases from Trypanosoma cruzi and Trypanosoma bruceiQ44437829
L-proline is essential for the intracellular differentiation of Trypanosoma cruzi.Q44965817
Succinate-dependent metabolism in Trypanosoma cruzi epimastigotesQ45135571
Assay and subcellular localization of pyrroline-5-carboxylate dehydrogenase in rat liverQ45145606
Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucoseQ45234598
Glucose uptake in the mammalian stages of Trypanosoma cruzi.Q45920237
Some factors inducing formation of metacyclic stages of Trypanosoma cruzi.Q46017904
P4510describes a project that usesImageJQ1659584
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectTrypanosoma cruziQ150162
P1104number of pages24
P304page(s)7767-7790
P577publication date2015-01-26
P1433published inJournal of Biological ChemistryQ867727
P1476titleRole of Δ1-pyrroline-5-carboxylate dehydrogenase supports mitochondrial metabolism and host-cell invasion of Trypanosoma cruzi
P478volume290

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cites work (P2860)
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Q89278076The active transport of histidine and its role in ATP production in Trypanosoma cruzi
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Q62234523Delta-1-pyrroline-5-carboxylate dehydrogenasedescribed by sourceP1343

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