Novel therapeutic strategies in prostate cancer management using gene therapy in combination with radiation therapy

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Novel therapeutic strategies in prostate cancer management using gene therapy in combination with radiation therapy is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S00345-003-0363-Y
P698PubMed publication ID12920560

P50authorSpencer J. CollisQ55303040
P2093author name stringTheodore L DeWeese
Kevin Khater
P2860cites workSite-specific integration by adeno-associated virusQ24558738
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cellsQ27860926
RNA interferenceQ28131798
Oncolytic herpes simplex virus vectors for cancer virotherapyQ28202611
Post-transcriptional gene silencing by double-stranded RNAQ28205087
Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1Q28210476
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cellsQ28215061
Metastasis to bone: causes, consequences and therapeutic opportunitiesQ29614310
In vivo protein transduction: delivery of a biologically active protein into the mouseQ29615482
Phase I dose escalation clinical trial of adenovirus vector carrying osteocalcin promoter-driven herpes simplex virus thymidine kinase in localized and metastatic hormone-refractory prostate cancerQ30310656
The National Cancer Data base Report on increased use of brachytherapy for the treatment of patients with prostate carcinoma in the U.S.Q30583616
Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transferQ31045537
Construction of a directed hammerhead ribozyme library: towards the identification of optimal target sites for antisense-mediated gene inhibitionQ31982706
Antitumor synergy of CV787, a prostate cancer-specific adenovirus, and paclitaxel and docetaxelQ32046446
Pegylated liposomal tumor necrosis factor-alpha results in reduced toxicity and synergistic antitumor activity after systemic administration in combination with liposomal doxorubicin (Doxil) in soft tissue sarcoma-bearing ratsQ33183242
In situ gene therapy for adenocarcinoma of the prostate: a phase I clinical trial.Q33328885
Role of RNase H in hybrid-arrested translation by antisense oligonucleotidesQ33631283
The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosisQ33783779
Sensible use of antisense: how to use oligonucleotides as research toolsQ33818938
Ad5CMVp53 gene therapy for locally advanced prostate cancer--where do we stand?Q33943092
Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: role of gap-junctional intercellular communication.Q34005910
CV706, a prostate cancer-specific adenovirus variant, in combination with radiotherapy produces synergistic antitumor efficacy without increasing toxicity.Q34084006
Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancerQ34106818
Advanced generation adenoviral vectors possess augmented gene transfer efficiency based upon coxsackie adenovirus receptor-independent cellular entry capacityQ34130442
Interactions between adenovirus proteins and the p53 pathway: the development of ONYX-015.Q34136649
Metastasis suppression: the evolving role of metastasis suppressor genes for regulating cancer cell growth at the secondary siteQ34176217
Clinical research results with dl1520 (Onyx-015), a replication-selective adenovirus for the treatment of cancer: what have we learned?Q34225918
Is alpha/beta for prostate tumors really low?Q34294994
Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomasQ34297434
RNA interference: listening to the sound of silenceQ34347832
Radiation therapy for the treatment of locally advanced and metastatic prostate cancerQ34348253
Selective elimination of mRNAs in vivo: complementary oligodeoxynucleotides promote RNA degradation by an RNase H-like activityQ34364533
An adenovirus mutant that replicates selectively in p53-deficient human tumor cellsQ34399844
Prostate attenuated replication competent adenovirus (ARCA) CN706: a selective cytotoxic for prostate-specific antigen-positive prostate cancer cells.Q34430883
Implication of cell kinetic changes during the progression of human prostatic cancerQ42725041
High-efficiency stable gene transfer of adenovirus into mammalian cells using ionizing radiationQ42799808
Inhibition of tumor growth by recombinant vaccinia virus expressing GA733/CO17-1A/EpCAM/KSA/KS1-4 antigen in miceQ42816298
Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes.Q42820783
RNA interference in adult mice.Q43038702
Human prostate carcinoma cells as targets for herpes simplex virus thymidine kinase-mediated suicide gene therapy.Q43550588
Enhanced therapeutic effect of HSV-tk+GCV gene therapy and ionizing radiation for prostate cancerQ43586837
A radiation-controlled molecular switch for use in gene therapy of cancer.Q43685592
The effect of local control on metastatic dissemination in carcinoma of the prostate: long-term results in patients treated with 125I implantationQ43688225
Replicating adenoviral vector-mediated transfer of a heat-inducible double suicide gene for gene therapyQ43703244
Therapeutic implications of enhanced G(0)/G(1) checkpoint control induced by coculture of prostate cancer cells with osteoblastsQ43719909
A hepatocellular carcinoma-specific adenovirus variant, CV890, eliminates distant human liver tumors in combination with doxorubicinQ43719922
Enhanced suicide gene effect by adenoviral transduction of a VP22-cytosine deaminase (CD) fusion geneQ43917987
Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trialQ44070350
Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancerQ44123699
Ionizing radiation potentiates the antitumor efficacy of oncolytic herpes simplex virus G207 by upregulating ribonucleotide reductase.Q44130120
Efficacy and toxicity of replication-competent adenovirus-mediated double suicide gene therapy in combination with radiation therapy in an orthotopic mouse prostate cancer modelQ44177727
Manganese superoxide dismutase gene therapy protects against irradiation-induced cystitisQ44212463
Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation.Q44220727
Persistence and expression of the adenosine deaminase gene for 12 years and immune reaction to gene transfer components: long-term results of the first clinical gene therapy trial.Q44232574
Ribozyme-mediated inhibition of PKCalpha sensitizes androgen-independent human prostate cancer cells to cisplatin-induced apoptosisQ44259379
In vivo antitumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapyQ44269918
Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors.Q44387424
A controlled, Phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA.Q44845726
Antioxidant enzyme expression and reactive oxygen species damage in prostatic intraepithelial neoplasia and cancerQ44873808
A phase I trial of CV706, a replication-competent, PSA selective oncolytic adenovirus, for the treatment of locally recurrent prostate cancer following radiation therapyQ45247385
Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectorsQ45299117
Replication-selective herpes simplex virus type 1 mutant therapy of cervical cancer is enhanced by low-dose radiationQ45733161
Preclinical safety evaluation of G207, a replication-competent herpes simplex virus type 1, inoculated intraprostatically in mice and nonhuman primatesQ45737125
Oncolytic viral therapy for human prostate cancer by conditionally replicating herpes simplex virus 1 vector G207.Q45739297
Fractionation and protraction for radiotherapy of prostate carcinomaQ77227878
Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancerQ77321070
Liposome-encapsulated tumor necrosis factor-alpha enhances the effects of radiation against human colon tumor xenograftsQ77362756
Radiation therapy for clinically localized prostate cancer: a multi-institutional pooled analysisQ77424028
Direct evidence that prostate tumors show high sensitivity to fractionation (low alpha/beta ratio), similar to late-responding normal tissueQ77451468
Herpes simplex virusQ77678102
Enhanced radiation sensitivity in prostate cancer by inhibition of the cell survival protein clusterinQ78358440
Prostate biopsy status and PSA nadir level as early surrogates for treatment failure: analysis of a prostate cancer randomized radiation dose escalation trialQ78365368
A tragic setbackQ78516025
Lentiviral-mediated RNA interferenceQ40675408
Suicide gene therapy using AAV-HSVtk/ganciclovir in combination with irradiation results in regression of human head and neck cancer xenografts in nude miceQ40678035
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complexQ40717443
Prostate-specific expression of the diphtheria toxin A chain (DT-A): studies of inducibility and specificity of expression of prostate-specific antigen promoter-driven DT-A adenoviral-mediated gene transfer.Q40735382
Preclinical study on gene therapy of cervical carcinoma using adeno-associated virus vectorsQ40763368
Development of synthetic promoters for radiation-mediated gene therapyQ40770533
Adenoviral-mediated p53 transgene expression sensitizes both wild-type and null p53 prostate cancer cells in vitro to radiationQ40836669
Adenovirus E4 34k and E4 11k inhibit double strand break repair and are physically associated with the cellular DNA-dependent protein kinaseQ40920540
Menage à trois: double strand break repair, V(D)J recombination and DNA-PK.Q40925823
A recombinant defective adenoviral agent expressing anti-bcl-2 ribozyme promotes apoptosis of bcl-2-expressing human prostate cancer cellsQ40935663
Potential benefit of improved local tumor control in patients with prostate carcinomaQ40988074
Identification of diphtheria toxin via screening as a potent cell cycle and p53-independent cytotoxin for human prostate cancer therapeuticsQ41060593
Sterically stabilized liposomes: a hypothesis on the molecular origin of the extended circulation timesQ41144469
Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.Q41563742
The addition of adenovirus type 5 region E3 enables calydon virus 787 to eliminate distant prostate tumor xenografts.Q41690221
An antibody-avidin fusion protein specific for the transferrin receptor serves as a delivery vehicle for effective brain targeting: initial applications in anti-HIV antisense drug delivery to the brain.Q41694333
The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.Q41736480
A good antisense molecule is hard to findQ41736928
Expression of human adenosine deaminase from various strong promoters after gene transfer into human hematopoietic cell linesQ41814575
Ionizing radiation does not alter the antitumor activity of herpes simplex virus vector G207 in subcutaneous tumor models of human and murine prostate cancerQ42353164
Modulation of innate immunological factors by STEALTH liposome-encapsulated tumor necrosis factor-alpha in a colon tumor xenograft model.Q42521473
Safety of single-dose administration of an adeno-associated virus (AAV)-CFTR vector in the primate lung.Q42524846
Oncolytic virotherapy for cancer with the adenovirus dl1520 (Onyx-015): results of phase I and II trialsQ34452020
Molecular approaches to chemo-radiotherapy.Q34501927
Adenoviral gene therapyQ34537888
ONYX-015. Onyx PharmaceuticalsQ34562778
Tissue-specific expression of an anti-ras ribozyme inhibits proliferation of human malignant melanoma cellsQ34591429
Targeted adenoviral vectorsQ34646701
Cancer gene therapy: 'delivery, delivery, delivery'Q34667233
Adenoviral vector-mediated gene transfer for human gene therapyQ34729274
Gene therapy of prostate cancer: current and future directionsQ34744823
Pathologic evidence of dose-response and dose-volume relationships for prostate cancer treated with combined external beam radiotherapy and high-dose-rate brachytherapyQ34786857
Tropism-modified adenoviral and adeno-associated viral vectors for gene therapyQ34791438
Antisense therapy: current status in prostate cancer and other malignanciesQ34980551
Antisense therapy for cancer--the time of truthQ34992794
Replication-defective genomic herpes simplex vectors: design and productionQ35012883
Liposomal delivery of nucleic acids in vivoQ35062247
In vivo DNA electrotransferQ35062251
Adenovirus and adeno-associated virus vectorsQ35062259
Gene delivery using herpes simplex virus vectorsQ35062264
Lentiviral vectors for gene delivery into cellsQ35062267
Progress and prospects: naked DNA gene transfer and therapyQ35079580
Therapeutic targets for metastatic prostate cancerQ35087863
Modulation of cellular function by TAT mediated transduction of full length proteinsQ35100870
TAT peptide internalization: seeking the mechanism of entry.Q35100881
The adenovirus death protein (E3-11.6K) is required at very late stages of infection for efficient cell lysis and release of adenovirus from infected cellsQ35858778
Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0.Q35871672
Ribozyme-mediated reversal of the multidrug-resistant phenotypeQ35897342
Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infectionQ36720691
The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteinsQ37162513
Ribozyme-mediated downregulation of human metallothionein II(a) induces apoptosis in human prostate and ovarian cancer cell linesQ38292701
Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cellsQ38302961
Adenovirus-mediated antisense ATM gene transfer sensitizes prostate cancer cells to radiationQ38307060
Expression of the coxsackie adenovirus receptor in normal prostate and in primary and metastatic prostate carcinoma: potential relevance to gene therapy.Q38456204
Herpes simplex virus type 1 immediate-early protein vmw110 induces the proteasome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase.Q39548922
Impact of improved local control on survivalQ39731992
Phase I/II trial evaluating combined radiotherapy and in situ gene therapy with or without hormonal therapy in the treatment of prostate cancer--a preliminary reportQ40595026
Cancer fears cast doubts on future of gene therapyQ40603071
Expression of the DNA-PK binding protein E4-34K fails to confer radiation sensitivity to mammalian cells.Q40607889
Oncolytic viral gene therapy for prostate cancer using two attenuated, replication-competent, genetically engineered herpes simplex virusesQ40632608
Local and systemic therapy of human prostate adenocarcinoma with the conditionally replicating herpes simplex virus vector G207.Q45747082
The role of herpes simplex virus glycoproteins in the virus replication cycle.Q45753486
Vaccinia virus for human gene therapy.Q45755568
A cascade of adenovirus early functions is required for expression of adeno-associated virusQ45800850
Regulated expression of diphtheria toxin in prostate cancer cellsQ45855448
Intraprostatic AD-p53 gene therapy followed by radical prostatectomy: feasibility and preliminary resultsQ45857349
Gene therapy. Seeking the cause of induced leukemias in X-SCID trialQ45858033
Cell phenotype specific kinetics of expression of intratracheally injected manganese superoxide dismutase-plasmid/liposomes (MnSOD-PL) during lung radioprotective gene therapyQ45858427
Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.Q45858661
Gene silencing by adenovirus-delivered siRNA.Q45859505
Induction of antitumor immunity by recombinant vaccinia viruses expressing B7-1 or B7-2 costimulatory moleculesQ45866282
T lymphocyte-directed gene therapy for ADA- SCID: initial trial results after 4 years.Q45866838
Prostate cancer radiosensitization in vivo with adenovirus-mediated p53 gene therapy.Q45872927
Overexpression of manganese superoxide dismutase (MnSOD) in whole lung or alveolar type II cells of MnSOD transgenic mice does not provide intrinsic lung irradiation protectionQ45875403
Prostate-specific targeting using PSA promoter-based lentiviral vectorsQ45880320
Additional gene therapy with Ad5CMV-p53 enhanced the efficacy of radiotherapy in human prostate cancer cells.Q45881811
Radioprotection of lung and esophagus by overexpression of the human manganese superoxide dismutase transgene.Q45883867
rAAV-mediated long-term liver-generated expression of an angiogenesis inhibitor can restrict renal tumor growth in miceQ45886543
Expression of ribozymes in gene transfer systems to modulate target RNA levelsQ45890110
BCL2 antisense reduces prostate cancer cell survival following irradiation.Q46014956
Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agentsQ46061653
Cationic lipids, phosphatidylethanolamine and the intracellular delivery of polymeric, nucleic acid-based drugs (review).Q47614304
Trojan peptides: the penetratin system for intracellular deliveryQ47721580
Naked DNA and adenoviral immunizations for immunotherapy of prostate cancer: a phase I/II clinical trial.Q53773145
System for robotically assisted prostate biopsy and therapy with intraoperative CT guidance.Q53876538
Cellular delivery of hammerhead ribozymes conjugated to a transferrin receptor antibody.Q54095850
Virus-mediated killing of cells that lack p53 activityQ59098652
Improved Survival in Patients with Locally Advanced Prostate Cancer Treated with Radiotherapy and GoserelinQ59364974
A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell NucleusQ63343005
Stepwise dismantling of adenovirus 2 during entry into cellsQ64377608
Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivoQ64377981
In vivo transfection and/or cross-priming of dendritic cells following DNA and adenoviral immunizations for immunotherapy of cancer--changes in peripheral mononuclear subsets and intracellular IL-4 and IFN-gamma lymphokine profileQ64379741
5-Fluorouracil modulation of radiosensitivity in cultured human carcinoma cellsQ68190354
Definitive irradiation and chemotherapy for radiosensitization in management of anal carcinoma: interim report on Radiation Therapy Oncology Group study no. 8314Q69615425
Age-related changes in the activities of antioxidant enzymes and lipid peroxidation status in ventral and dorsolateral prostate lobes of noble ratsQ71160071
An uncertain role for p53 gene alterations in human prostate cancersQ71254302
Androgen deprivation with radiation therapy compared with radiation therapy alone for locally advanced prostatic carcinoma: a randomized comparative trial of the Radiation Therapy Oncology GroupQ72156114
Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissueQ72851913
A phase I trial of autologous CD34+ hematopoietic progenitor cells transduced with an anti-HIV ribozymeQ73022564
Pharmacokinetics and tolerability of an antiangiogenic ribozyme (ANGIOZYME) in healthy volunteersQ73456912
Expression of antioxidant enzymes in human prostatic adenocarcinomaQ73676423
Cell-cycle arrest versus cell death in cancer therapyQ73677622
Antisense TRPM-2 oligodeoxynucleotides chemosensitize human androgen-independent PC-3 prostate cancer cells both in vitro and in vivoQ73803349
Enhancing efficacy of recombinant anticancer vaccines with prime/boost regimens that use two different vectorsQ73856260
Risk group dependence of dose-response for biopsy outcome after three-dimensional conformal radiation therapy of prostate cancerQ74300566
Efficient delivery of siRNA for inhibition of gene expression in postnatal miceQ74531314
Sensitivity of human prostatic carcinoma cell lines to low dose rate radiation exposureQ74738676
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectadaptive radiation therapyQ180507
prostate cancerQ181257
gene therapyQ213901
P304page(s)275-289
P577publication date2003-08-13
P1433published inWorld Journal of UrologyQ15750774
P1476titleNovel therapeutic strategies in prostate cancer management using gene therapy in combination with radiation therapy
P478volume21

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cites work (P2860)
Q40488102Adenovirus-mediated FLT1-targeted proapoptotic gene therapy of human prostate cancer
Q45880240Combined ionizing radiation and sKDR gene delivery for treatment of prostate carcinomas.
Q36429405The present and future for gene and viral therapy of directly accessible prostate and squamous cell cancers of the head and neck
Q24811943U94 alters FN1 and ANGPTL4 gene expression and inhibits tumorigenesis of prostate cancer cell line PC3.

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