Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch

scientific article

Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1093/BJA/AER260
P932PMC publication ID3169333
P698PubMed publication ID21852280
P5875ResearchGate publication ID51581406

P50authorKeith BleyQ125054991
P2093author name stringP Anand
P2860cites workTRP channels and painQ83830678
Microneurographic findings of relevance to pain in patients with erythromelalgia and patients with diabetic neuropathyQ83949996
Analgesic therapy in postherpetic neuralgia: a quantitative systematic reviewQ21144723
Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodentsQ21146964
Topical capsaicin for chronic neuropathic pain in adultsQ24240399
Increased capsaicin receptor TRPV1 in skin nerve fibres and related vanilloid receptors TRPV3 and TRPV4 in keratinocytes in human breast painQ24803051
Microneurographic single-unit recordings to assess receptive properties of afferent human C-fibersQ28246859
The concept of neurogenic inflammationQ28270661
Vanilloid (Capsaicin) receptors and mechanismsQ29617371
Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia.Q30704153
Expression of capsaicin receptor immunoreactivity in human peripheral nervous system and in painful neuropathiesQ33255110
Use of the novel Contact Heat Evoked Potential Stimulator (CHEPS) for the assessment of small fibre neuropathy: correlations with skin flare responses and intra-epidermal nerve fibre countsQ33293409
Human keratinocytes are vanilloid resistantQ33375740
The time course of CO2 laser-evoked responses and of skin nerve fibre markers after topical capsaicin in human volunteersQ33546873
Effects of the neurotrophic factor artemin on sensory afferent development and sensitivityQ33585155
Capsaicin induces degeneration of cutaneous autonomic nerve fibersQ33742339
Nerve growth factor and keratinocytes: a role in psoriasisQ33849908
NK1 (substance P) receptor antagonists--why are they not analgesic in humans?Q33953249
Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell deathQ34001869
Tanezumab, a recombinant humanized mAb against nerve growth factor for the treatment of acute and chronic painQ34097542
Evidence for the efficacy of complementary and alternative medicines in the management of osteoarthritis: a systematic reviewQ34155583
Postherpetic neuralgia: irritable nociceptors and deafferentationQ34483000
Neuropathic pain: redefinition and a grading system for clinical and research purposesQ34713765
Chronic nerve growth factor administration increases the peripheral exocytotic activity of capsaicin-sensitive cutaneous neurons.Q53617813
Final Report on the Safety Assessment of Capsicum Annuum Extract, Capsicum Annuum Fruit Extract, Capsicum Annuum Resin, Capsicum Annuum Fruit Powder, Capsicum Frutescens Fruit, Capsicum Frutescens Fruit Extract, Capsicum Frutescens Resin, and CapsaicQ56093618
Transient Receptor Potential Vanilloid Receptor Subtype 1 in Painful Bladder Syndrome and its Correlation With PainQ60731291
Vanilloid receptor 1 immunoreactivity in inflamed human bowelQ60731295
Psychophysical evidence of nociceptor sensitization in vulvar vestibulitis syndromeQ60774817
Increased intraepithelial innervation in women with vulvar vestibulitis syndromeQ60774822
Nerve fibre proliferation in interstitial cystitisQ61614704
Therapeutic studies on vulvar vestibulitisQ67923877
Capsaicin and its analogs inhibit the activity of NADH-coenzyme Q oxidoreductase of the mitochondrial respiratory chainQ69189528
The role of endogenous nerve growth factor in human diabetic neuropathyQ71101919
Idiopathic vulvodynia. Clinical evaluation of the pain threshold with acetic acid solutionsQ71871120
Capsaicin-induced neurotoxicity in cultured dorsal root ganglion neurons: involvement of calcium-activated proteasesQ71899054
Mechanism of inhibitory action of capsaicin on particulate axoplasmic transport in sensory neurons in cultureQ72086756
Preventative effect of repeated nasal applications of capsaicin in cluster headacheQ72137018
Inhibition of Axon Reflex Vasodilatation by Topically Applied CapsaicinQ72634202
Early onset of spontaneous activity in uninjured C-fiber nociceptors after injury to neighboring nerve fibersQ73764922
Uninjured C-fiber nociceptors develop spontaneous activity and alpha-adrenergic sensitivity following L6 spinal nerve ligation in monkeyQ74482520
Neuropeptides in the skin: interactions between the neuroendocrine and the skin immune systemsQ74534991
Quantitative analysis of epidermal innervation in Fabry diseaseQ77360442
Intradermal injection of capsaicin in humans produces degeneration and subsequent reinnervation of epidermal nerve fibers: correlation with sensory functionQ77458793
Mechanisms of neuropathic painQ79173262
Topical treatment of chronic low back pain with a capsicum plasterQ79213613
Nociception and TRP channelsQ79540571
Impaired reinnervation in HIV infection following experimental denervationQ80167210
NGF-mediated sensitization of the excitability of rat sensory neurons is prevented by a blocking antibody to the p75 neurotrophin receptorQ80382886
Neuronal markers in allergic rhinitis: expression and correlation with sensory testingQ80712410
Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome-I (reflex sympathetic dystrophy)Q82329571
Determinants of epidermal nerve fiber density in normal individualsQ82759217
Controlled trial of high-concentration capsaicin patch for treatment of painful HIV neuropathyQ34785640
Beyond neurons: evidence that immune and glial cells contribute to pathological pain statesQ34882677
Topical therapy for osteoarthritis: clinical and pharmacologic perspectivesQ34971645
Neurotrophic factors and their receptors in human sensory neuropathiesQ35618389
Opportunities afforded by the study of unmyelinated nerves in skin and other organsQ35788249
Intranasal medications for the treatment of migraine and cluster headacheQ35843543
Capsaicin for the treatment of vulvar vestibulitisQ36131975
Epidermal transient receptor potential vanilloid 1 in idiopathic small nerve fibre disease, diabetic neuropathy and healthy human subjects.Q36237923
Assessment of cutaneous sensory and autonomic axon reflexes in rheumatoid arthritisQ36705051
Quantitation of epidermal nerves in diabetic neuropathyQ36825566
Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal painQ36930795
The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensorQ37023861
The role of P2X₇ in pain and inflammationQ37135501
Transient receptor potential vanilloid subtype 1 channel mediated neuropeptide secretion and depressor effects: role of endoplasmic reticulum associated Ca2+ release receptors in rat dorsal root ganglion neuronsQ37160064
Vulvodynia & pelvic pain? Think interstitial cystitisQ37309062
Current perspectives in vulvodynia.Q37544852
The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation.Q37629063
Topical capsaicin. The fire of a 'hot' medicine is reignitedQ37743506
Calcitonin gene-related peptide receptor antagonists for migraineQ37756158
Capsaicin dermal patch: in non-diabetic peripheral neuropathic painQ37788207
A "cute" desensitization of TRPV1.Q37798852
NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind studyQ39312497
The potential role of nerve growth factor (NGF) in painful neuromas and the mechanism of pain relief by their relocation to muscleQ39346943
Review of the effectiveness of capsaicin for painful cutaneous disorders and neural dysfunctionQ39446855
Treatment of intractable pain with topical large-dose capsaicin: preliminary reportQ39450327
Topical Capsaicin in Painful Diabetic Neuropathy: Controlled Study With Long-Term Follow-UpQ39504269
TRPV1 shows dynamic ionic selectivity during agonist stimulation.Q39994761
Transient receptor potential vanilloid-1 mediates heat-shock-induced matrix metalloproteinase-1 expression in human epidermal keratinocytesQ40131858
Capsaicin-induced depletion of substance P from primary sensory neuronesQ40164536
TRPV1 at nerve endings regulates growth cone morphology and movement through cytoskeleton reorganizationQ40173261
Glial cell-line-derived neurotrophic factor expression in skin alters the mechanical sensitivity of cutaneous nociceptors.Q40304242
Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathyQ40667434
Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgencyQ40672234
TRPV3 is a temperature-sensitive vanilloid receptor-like protein.Q40723123
Capsaicin-induced depolarisation of mitochondria in dorsal root ganglion neurons is enhanced by vanilloid receptorsQ40811651
Capsaicin in hot chili pepper: carcinogen, co-carcinogen or anticarcinogen?Q40982024
Neuropathological alterations in diabetic truncal neuropathy: evaluation by skin biopsy.Q42051248
Increased NGF mRNA expression in denervated rat skin.Q42512072
Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain scoreQ42514396
p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesiaQ42526677
The endoplasmic reticulum of dorsal root ganglion neurons contains functional TRPV1 channelsQ42661952
Long-term safety of NGX-4010, a high-concentration capsaicin patch, in patients with peripheral neuropathic painQ43032039
Natural history of cutaneous innervation following herpes zosterQ43067287
A randomized, controlled, open-label study of the long-term effects of NGX-4010, a high-concentration capsaicin patch, on epidermal nerve fiber density and sensory function in healthy volunteersQ43094995
Capsicum pain plaster in chronic non-specific low back painQ43838908
The influence of local capsaicin treatment on small nerve fibre function and neurovascular control in symptomatic diabetic neuropathyQ44013935
The density of remaining nerve endings in human skin with and without postherpetic neuralgia after shinglesQ44038120
Small fiber neuropathy is associated with the metabolic syndromeQ44207440
Repeated intranasal capsaicin applications to treat chronic migraineQ44452962
Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factorQ44483450
Genotoxicity studies with pure trans-capsaicin.Q44714424
Increased vanilloid receptor VR1 innervation in vulvodyniaQ44778793
The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathyQ44884912
Intraepidermal nerve fibers are indicators of small-fiber neuropathy in both diabetic and nondiabetic patientsQ44903849
Increased capsaicin receptor TRPV1 nerve fibres in the inflamed human oesophagus.Q45022108
Reduced heat sensitivity and epidermal nerve fiber immunostaining following single applications of a high-concentration capsaicin patchQ45056095
Symptoms of Notalgia Paresthetica May Be Explained by Increased Dermal InnervationQ45356904
Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon.Q45982096
Pharmacokinetic analysis of capsaicin after topical administration of a high-concentration capsaicin patch to patients with peripheral neuropathic pain.Q45983561
Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level.Q46101053
Cutaneous innervation density in the allodynic form of postherpetic neuralgiaQ46232843
Capsaicin and the treatment of vulvar vestibulitis syndrome: a valuable alternative?Q46388325
Hyperexcitable polymodal and insensitive nociceptors in painful human neuropathyQ46562554
In vitro hepatic and skin metabolism of capsaicinQ46819105
A double-blind placebo-controlled trial of intranasal capsaicin for cluster headacheQ47635748
Efficacy, safety, and tolerability of NGX-4010, capsaicin 8% patch, in an open-label study of patients with peripheral neuropathic painQ48260903
A Multicenter, Randomized, Double-Blind, Controlled Study of NGX-4010, a High-Concentration Capsaicin Patch, for the Treatment of Postherpetic NeuralgiaQ50440477
Sensitisation of visceral afferents by nerve growth factor in the adult rat.Q50537945
Expression of the TRPV1 receptor differs in quiescent inflammatory bowel disease with or without abdominal pain.Q50687545
Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors.Q51282145
Nerve growth factor signaling regulates motility and docking of axonal mitochondria.Q51642532
Capsaicin causes protein synthesis inhibition and microtubule disassembly through TRPV1 activities both on the plasma membrane and intracellular membranes.Q53579259
P275copyright licenseCreative Commons Attribution-NonCommercialQ6936496
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectpainQ81938
analgesicQ173235
capsaicinQ273169
P304page(s)490-502
P577publication date2011-08-17
2011-10-01
P1433published inBritish Journal of AnaesthesiaQ72466
P1476titleTopical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch
P478volume107

Reverse relations

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